DMPX

Chemical compound
  • None
Identifiers
  • 3,7-Dimethyl-1-(2-propyn-1-yl)-3,7-dihydro-1H-purine-2,6-dione
CAS Number
  • 14114-46-6 checkY
PubChem CID
  • 99562
ChemSpider
  • 89948
UNII
  • 5YFR5SPS6T
CompTox Dashboard (EPA)
  • DTXSID30161577 Edit this at Wikidata
ECHA InfoCard100.162.258 Edit this at WikidataChemical and physical dataFormulaC10H10N4O2Molar mass218.216 g·mol−13D model (JSmol)
  • Interactive image
  • Cn2cnc(c2c1=O)n(C)c(=O)n1CC#C
InChI
  • InChI=1S/C10H10N4O2/c1-4-5-14-9(15)7-8(11-6-12(7)2)13(3)10(14)16/h1,6H,5H2,2-3H3
  • Key:IORPOFJLSIHJOG-UHFFFAOYSA-N

DMPX (3,7-dimethyl-1-propargylxanthine) is a caffeine analog which displays affinity to A2 adenosine receptors, in contrast to the A1 subtype receptors.[1] DMPX had 28× and 15× higher potency than caffeine in blocking peripheral and central NECA-responses. The locomotor stimulation caused by DMPX (ED50 10 μmol/kg) was similarly higher than caffeine.[1]

See also

  • DPCPX
  • 8-PT
  • CPX (8-CPT)
  • 8-Chlorotheophylline
  • Theophylline

References

  1. ^ a b Seale TW, Abla KA, Shamim MT, Carney JM, Daly JW (1988). "3,7-Dimethyl-1-propargylxanthine: a potent and selective in vivo antagonist of adenosine analogs". Life Sciences. 43 (21): 1671–84. doi:10.1016/0024-3205(88)90478-x. PMID 3193854.
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Stimulants
AdamantanesAdenosine antagonistsAlkylaminesAmpakinesArylcyclohexylaminesBenzazepinesCathinonesCholinergicsConvulsantsEugeroicsOxazolinesPhenethylamines
PhenylmorpholinesPiperazinesPiperidinesPyrrolidinesRacetamsTropanesTryptaminesOthers
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Receptor
(ligands)
P0 (adenine)
P1
(adenosine)
P2
(nucleotide)
P2X
(ATPTooltip Adenosine triphosphate)
P2Y
Transporter
(blockers)
CNTsTooltip Concentrative nucleoside transporters
ENTsTooltip Equilibrative nucleoside transporters
PMATTooltip Plasma membrane monoamine transporter
Enzyme
(inhibitors)
XOTooltip Xanthine oxidase
Others
Others
See also: Receptor/signaling modulators