GBR-13098
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| IUPAC name 1-{2-[Bis(4-fluorophenyl)methoxy]ethyl}-4-[3-(4-fluorophenyl)propyl]piperazine;methanesulfonic acid | |
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| Properties | |
Chemical formula | C30H39F3N2O7S2 |
| Molar mass | 660.76 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references | |
Chemical compound
GBR-13098 is a psychostimulant and selective dopamine uptake inhibitor.[1]
Blocking the endogenous striatal dopamine (DA) transporter with GBR-13098 in mice has been shown to prevent damage to the DA nerve terminals caused by malonate. It was suggested that DA transporter inhibitors like GBR-13098 could be used to prevent or treat neurodegenerative disorders caused by the effect of mitochondrial dysfunction on DA homeostasis.[2]
See also
- Vanoxerine
- GBR-12783
- GBR-12935
- GBR-13069
- DBL-583
References
- ^ Pileblad E, and Engberg G. (Dec 1986). "GBR 13098, a selective dopamine uptake inhibitor; behavioural, biochemical and electrophysiological studies". Naunyn-Schmiedeberg's Arch Pharmacol. 334 (4): 383–7. doi:10.1007/BF00569374. PMID 2950328. S2CID 4685374.
- ^ Moy LY; et al. (Feb 2007). "Mitochondrial stress-induced dopamine efflux and neuronal damage by malonate involves the dopamine transporter". J Pharmacol Exp Ther. 320 (2): 747–56. doi:10.1124/jpet.106.110791. PMID 17090704. S2CID 9886591.
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