Receptor gastričnog inhibitornog polipeptida

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Receptor gastričnog inhibitornog polipeptida‎
Dostupne strukture
2QKH
Identifikatori
SimboliGIPR; PGQTL2
Vanjski IDOMIM: 137241 MGI: 1352753 HomoloGene: 20081 IUPHAR: GIP GeneCards: GIPR Gene
Ontologija gena
Molekularna funkcija • aktivnost transmembranskog signalnog receptora
• aktivnost gastričnog inhibitornog peptidnog receptora
• vezivanje peptidnog hormona
Celularna komponenta • ćelijska membrana
• integralno sa membranom
Biološki proces • signalni put desenzitizacije G-protein spregnutog receptora
• formiranje prekursorskih metabolita i energije
• signalni put ćelijskog receptora
Pregled RNK izražavanja
podaci
Ortolozi
VrstaČovekMiš
Entrez2696381853
EnsemblENSG00000010310ENSMUSG00000030406
UniProtP48546Q0P543
RefSeq (mRNA)NM_000164.2NM_001080815.1
RefSeq (protein)NP_000155.1NP_001074284.1
Lokacija (UCSC)Chr 19:
46.17 - 46.19 Mb		Chr 7:
19.74 - 19.75 Mb
PubMed pretraga[1][2]

Receptor gastričnog inhibitornog polipeptida (GIP-R, glukozno zavisni insulinotropni polipeptidni receptor) je protein koji je kod ljudi kodiran GIPR genom.[1][2] GIP-R je sedam transmembranski protein prisutan u beta ćelijama u pancreasu.[3][4]

Funkcija

Gastrični inhibitorni polipeptid (GIP, glukozno zavisni insulinotropni polipeptid) je 42 aminokiseline dug polipeptid koji sintetišu K ćelije dvanaestopalačnog i tankih creva. On je originalno identifikovan kao sastojak stomačnog ekstrakta koji inhibira sekreciju želudačne kiseline i oslobađanje gastrina, ali je naknadno pokazano da potentno stimuliše otpuštanje insulina u prisustvu povišenih nivoa glukoze. Insulinotropno dejstvo na pankreasne beta ćelije je stoga njegova glavna fiziološka uloga. Zajedno sa glukagonu sličnim peptidom-1, GIP je u velikoj meri odgovoran za sekreciju insulina nakon jela. On učestvuje u nekoliko različitih oblika anaboličkog otpuštaja.[1]

Reference

  1. ↑ 1,0 1,1 „Entrez Gene: gastric inhibitory polypeptide receptor”. 
  2. ↑ Stoffel M, Fernald AA, Le Beau MM, Bell GI (August 1995). „Assignment of the gastric inhibitory polypeptide receptor gene (GIPR) to chromosome bands 19q13.2-q13.3 by fluorescence in situ hybridization”. Genomics 28 (3): 607–609. DOI:10.1006/geno.1995.1203. PMID 7490109. 
  3. ↑ „Gastrointestinal Hormones and Peptides”. Arhivirano iz originala na datum 2007-12-06. Pristupljeno 24. 08. 2007. 
  4. ↑ Brubaker PL, Drucker DJ (2002). „Structure-function of the glucagon receptor family of G protein-coupled receptors: the glucagon, GIP, GLP-1, and GLP-2 receptors”. Recept. Channels 8 (3–4): 179–188. DOI:10.1080/10606820213687. PMID 12529935. 

Literatura

  • Yamada Y, Seino Y (2005). „Physiology of GIP--a lesson from GIP receptor knockout mice”. Horm. Metab. Res. 36 (11–12): 771–774. DOI:10.1055/s-2004-826162. PMID 15655707. 
  • Gremlich S, Porret A, Hani EH i dr.. (1995). „Cloning, functional expression, and chromosomal localization of the human pancreatic islet glucose-dependent insulinotropic polypeptide receptor”. Diabetes 44 (10): 1202–1208. DOI:10.2337/diabetes.44.10.1202. PMID 7556958. 
  • Volz A, Göke R, Lankat-Buttgereit B i dr.. (1995). „Molecular cloning, functional expression, and signal transduction of the GIP-receptor cloned from a human insulinoma”. FEBS Lett. 373 (1): 23–29. DOI:10.1016/0014-5793(95)01006-Z. PMID 7589426. 
  • Usdin TB, Mezey E, Button DC i dr.. (1994). „Gastric inhibitory polypeptide receptor, a member of the secretin-vasoactive intestinal peptide receptor family, is widely distributed in peripheral organs and the brain”. Endocrinology 133 (6): 2861–2870. DOI:10.1210/en.133.6.2861. PMID 8243312. 
  • Yamada Y, Hayami T, Nakamura K i dr.. (1996). „Human gastric inhibitory polypeptide receptor: cloning of the gene (GIPR) and cDNA”. Genomics 29 (3): 773–776. DOI:10.1006/geno.1995.9937. PMID 8575774. 
  • Gallwitz B, Witt M, Morys-Wortmann C i dr.. (1997). „GLP-1/GIP chimeric peptides define the structural requirements for specific ligand-receptor interaction of GLP-1”. Regul. Pept. 63 (1): 17–22. DOI:10.1016/0167-0115(96)00019-5. PMID 8795084. 
  • N'Diaye N, Tremblay J, Hamet P i dr.. (1998). „Adrenocortical overexpression of gastric inhibitory polypeptide receptor underlies food-dependent Cushing's syndrome”. J. Clin. Endocrinol. Metab. 83 (8): 2781–2785. DOI:10.1210/jc.83.8.2781. PMID 9709947. 
  • Tseng CC, Zhang XY (2000). „Role of G protein-coupled receptor kinases in glucose-dependent insulinotropic polypeptide receptor signaling”. Endocrinology 141 (3): 947–952. DOI:10.1210/en.141.3.947. PMID 10698169. 
  • Bollag RJ, Zhong Q, Phillips P i dr.. (2000). „Osteoblast-derived cells express functional glucose-dependent insulinotropic peptide receptors”. Endocrinology 141 (3): 1228–1235. DOI:10.1210/en.141.3.1228. PMID 10698200. 
  • Strausberg RL, Feingold EA, Grouse LH i dr.. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Baldacchino V, Oble S, Hamet P i dr.. (2003). „Partial characterisation of the 5' flanking region of the human GIP receptor (GIPR) gene”. Endocr. Res. 28 (4): 577–577. DOI:10.1081/ERC-120016843. PMID 12530665. 
  • Antonini SR, N'Diaye N, Hamet P i dr.. (2003). „Analysis of the putative promoter region of the GIP receptor gene (GIPR) in GIP-dependent Cushing's syndrome (CS)”. Endocr. Res. 28 (4): 755–756. DOI:10.1081/ERC-120017003. PMID 12530694. 
  • Manhart S, Hinke SA, McIntosh CH i dr.. (2003). „Structure-function analysis of a series of novel GIP analogues containing different helical length linkers”. Biochemistry 42 (10): 3081–3088. DOI:10.1021/bi026868e. PMID 12627975. 
  • Ding KH, Zhong Q, Isales CM (2003). „Glucose-dependent insulinotropic peptide stimulates thymidine incorporation in endothelial cells: role of endothelin-1”. Am. J. Physiol. Endocrinol. Metab. 285 (2): E390–6. DOI:10.1152/ajpendo.00509.2002. PMID 12721154. 
  • Grimwood J, Gordon LA, Olsen A i dr.. (2004). „The DNA sequence and biology of human chromosome 19”. Nature 428 (6982): 529–535. DOI:10.1038/nature02399. PMID 15057824. 
  • Hansotia T, Baggio LL, Delmeire D i dr.. (2004). „Double incretin receptor knockout (DIRKO) mice reveal an essential role for the enteroinsular axis in transducing the glucoregulatory actions of DPP-IV inhibitors”. Diabetes 53 (5): 1326–1335. DOI:10.2337/diabetes.53.5.1326. PMID 15111503. 
  • Gerhard DS, Wagner L, Feingold EA i dr.. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121–2127. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334. 
  • Baldacchino V, Oble S, Hamet P i dr.. (2005). „The Sp transcription factor family is involved in the cellular expression of the human GIP-R gene promoter”. Endocr. Res. 30 (4): 805–806. DOI:10.1081/ERC-200044046. PMID 15666829. 

Vidi još

Spoljašnje veze

  • „Glucagon Receptor Family: GIP”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-03-03. 
  • MeSH gastric+inhibitory+polypeptide+receptor
  • p
  • r
  • u
Klasa A: Rodopsinu slični
α1 (A, B, D) • α2 (A, B, C) • β1 • β2 • β3
Adenozinski (A1, A2A, A2B, A3) • P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
(svi osim 5-HT3) 5-HT1 (A, B, D, E, F) • 5-HT2 (A, B, C) • 5-HT (4, 5A, 6, 7)
Drugi
Acetilholin (M1, M2, M3, M4, M5) • Dopamin (D1, D2, D3, D4, D5) • Histamin (H1, H2, H3, H4) • Melatonin (1A, 1B, 1C) • TAAR (1, 2, 3, 5, 6, 8, 9)
Metaboliti i
signalni molekuli
CysLT (1, 2) • LTB4 (1, 2) • FPRL1 • OXE • Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) • Prostaciklin • Tromboksan
Drugi
Žučna kiselina • Kanabinoidni (CB1, CB2, GPR (18, 55, 119)) • EBI2 • Estrogen • Slobodna masna kiselina (1, 2, 3, 4) • Laktat  • Lizofosfatidna kiselina (1, 2, 3, 4, 5, 6)  • Lizofosfolipid (1, 2, 3, 4, 5, 6, 7, 8) • Niacin (1, 2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1, 2, 3, 4, 5) • Sukcinat
Peptid
B/W (1, 2) • FF (1, 2) • S • Y (1, 2, 4, 5) • Neuromedin (B, U (1, 2)) • Neurotenzin (1, 2)
Drugi
Anafilatoksin (C3a, C5a) • Angiotenzin (1, 2) • Apelin • Bombezin (BRS3, GRPR, NMBR) • Bradikinin (B1, B2) • Hemokin • Holecistokinin (A, B) • Endotelin (A, B) • Formil peptid (1, 2, 3) • FSH • Galanin (1, 2, 3) • GHB receptor • Gonadotropin-oslobađajući hormon (1, 2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) • Melanokortin (1, 2, 3, 4, 5) • MCHR (1, 2) • Motilin • Opioidni (δ, κ, μ, Nociceptin & ζ, ali ne σ) • Oreksin (1, 2) • Oksitocin • Prokineticin (1, 2) • Prolaktin-oslobađajući peptid • Relaksin (1, 2, 3, 4) • Somatostatin (1, 2, 3, 4, 5) • Tahikinin (1, 2, 3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A, 1B, 2)
Razno
GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Drugi
Adrenomedulin • Mirisni • Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) • Proteazom-aktivirani (1, 2, 3, 4) • SREB (1, 2, 3)
Klasa B: Sekretinu slični
GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Drugi
Klasa C: Metabotropni
glutamat / feromon
TAS1R (1, 2, 3) • TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Drugi
Klasa F:
Frizzled / Zaglađeni
Uvojiti
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)
Zaglađeni
B trdu: peptidi (nrpl/grfl/cytl/horl), receptori (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd, signalni putevi (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)