Receptor glukagonu sličnog peptida 2

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Receptor glukagonu sličnog peptida 2
Identifikatori
SimbolGLP2R
Vanjski IDOMIM: 603659 MGI: 2136733 HomoloGene: 3132 IUPHAR: GLP-2 GeneCards: GLP2R Gene
Ontologija gena
Molekularna funkcija • aktivnost G protein spregnutog receptora
• aktivnost glukagonskog receptora
Celularna komponenta • integralno sa ćelijskom membranom
• integralno sa membranom
Biološki proces • metabolički proces energetske rezerve
• signalni put G-protein spregnutog receptor aktiviranog adenilat ciklazom
• aktivacija adenilat ciklazne aktivnosti
Pregled RNK izražavanja
podaci
Ortolozi
VrstaČovekMiš
Entrez934093896
EnsemblENSG00000065325ENSMUSG00000049928
UniProtO95838Q5IXF8
RefSeq (mRNA)NM_004246.1NM_175681.3
RefSeq (protein)NP_004237.1NP_783612.2
Lokacija (UCSC)Chr 17:
9.73 - 9.8 Mb		Chr 11:
67.48 - 67.58 Mb
PubMed pretraga[1][2]

Gen za receptor glukagonu sličnog peptida 2 (GLP-2) se nalazi na hromozomu 17.[1]

Reference

  1. ↑ Brubaker PL, Drucker DJ (2002). „Structure-function of the glucagon receptor family of G protein-coupled receptors: the glucagon, GIP, GLP-1, and GLP-2 receptors”. Recept. Channels 8 (3–4): 179–88. DOI:10.1080/10606820213687. PMID 12529935. Arhivirano iz originala na datum 2006-10-20. Pristupljeno 2007-08-24. 

Literatura

  • Burrin DG, Petersen Y, Stoll B, Sangild P (2001). „Glucagon-like peptide 2: a nutrient-responsive gut growth factor”. J. Nutr. 131 (3): 709–12. PMID 11238747. 
  • Munroe DG, Gupta AK, Kooshesh F i dr.. (1999). „Prototypic G protein-coupled receptor for the intestinotrophic factor glucagon-like peptide 2”. Proc. Natl. Acad. Sci. U.S.A. 96 (4): 1569–73. DOI:10.1073/pnas.96.4.1569. PMC 15520. PMID 9990065. 
  • Yusta B, Huang L, Munroe D i dr.. (2000). „Enteroendocrine localization of GLP-2 receptor expression in humans and rodents”. Gastroenterology 119 (3): 744–55. DOI:10.1053/gast.2000.16489. PMID 10982769. 
  • Thulesen J, Knudsen LB, Hartmann B i dr.. (2002). „The truncated metabolite GLP-2 (3-33) interacts with the GLP-2 receptor as a partial agonist”. Regul. Pept. 103 (1): 9–15. DOI:10.1016/S0167-0115(01)00316-0. PMID 11738243. 
  • Strausberg RL, Feingold EA, Grouse LH i dr.. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Koehler JA, Yusta B, Drucker DJ (2005). „The HeLa cell glucagon-like peptide-2 receptor is coupled to regulation of apoptosis and ERK1/2 activation through divergent signaling pathways”. Mol. Endocrinol. 19 (2): 459–73. DOI:10.1210/me.2004-0196. PMID 15471943. 
  • Ørskov C, Hartmann B, Poulsen SS i dr.. (2005). „GLP-2 stimulates colonic growth via KGF, released by subepithelial myofibroblasts with GLP-2 receptors”. Regul. Pept. 124 (1–3): 105–12. DOI:10.1016/j.regpep.2004.07.009. PMID 15544847. 
  • Mahon MJ, Shimada M (2005). „Calmodulin interacts with the cytoplasmic tails of the parathyroid hormone 1 receptor and a sub-set of class b G-protein coupled receptors”. FEBS Lett. 579 (3): 803–7. DOI:10.1016/j.febslet.2004.12.056. PMID 15670850. 
  • Estall JL, Koehler JA, Yusta B, Drucker DJ (2005). „The glucagon-like peptide-2 receptor C terminus modulates beta-arrestin-2 association but is dispensable for ligand-induced desensitization, endocytosis, and G-protein-dependent effector activation”. J. Biol. Chem. 280 (23): 22124–34. DOI:10.1074/jbc.M500078200. PMID 15817468. 
  • Guan X, Karpen HE, Stephens J i dr.. (2006). „GLP-2 receptor localizes to enteric neurons and endocrine cells expressing vasoactive peptides and mediates increased blood flow”. Gastroenterology 130 (1): 150–64. DOI:10.1053/j.gastro.2005.11.005. PMID 16401478. 
  • Sams A, Hastrup S, Andersen M, Thim L (2006). „Naturally occurring glucagon-like peptide-2 (GLP-2) receptors in human intestinal cell lines”. Eur. J. Pharmacol. 532 (1–2): 18–23. DOI:10.1016/j.ejphar.2005.12.001. PMID 16448646. 

Vidi još

Spoljašnje veze

  • „Glucagon Receptor Family: GLP-2”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2015-02-16. 
  • MeSH glucagon-like+peptide+receptor
  • p
  • r
  • u
Klasa A: Rodopsinu slični
α1 (A, B, D) • α2 (A, B, C) • β1 • β2 • β3
Adenozinski (A1, A2A, A2B, A3) • P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
(svi osim 5-HT3) 5-HT1 (A, B, D, E, F) • 5-HT2 (A, B, C) • 5-HT (4, 5A, 6, 7)
Drugi
Acetilholin (M1, M2, M3, M4, M5) • Dopamin (D1, D2, D3, D4, D5) • Histamin (H1, H2, H3, H4) • Melatonin (1A, 1B, 1C) • TAAR (1, 2, 3, 5, 6, 8, 9)
Metaboliti i
signalni molekuli
CysLT (1, 2) • LTB4 (1, 2) • FPRL1 • OXE • Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) • Prostaciklin • Tromboksan
Drugi
Žučna kiselina • Kanabinoidni (CB1, CB2, GPR (18, 55, 119)) • EBI2 • Estrogen • Slobodna masna kiselina (1, 2, 3, 4) • Laktat  • Lizofosfatidna kiselina (1, 2, 3, 4, 5, 6)  • Lizofosfolipid (1, 2, 3, 4, 5, 6, 7, 8) • Niacin (1, 2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1, 2, 3, 4, 5) • Sukcinat
Peptid
B/W (1, 2) • FF (1, 2) • S • Y (1, 2, 4, 5) • Neuromedin (B, U (1, 2)) • Neurotenzin (1, 2)
Drugi
Anafilatoksin (C3a, C5a) • Angiotenzin (1, 2) • Apelin • Bombezin (BRS3, GRPR, NMBR) • Bradikinin (B1, B2) • Hemokin • Holecistokinin (A, B) • Endotelin (A, B) • Formil peptid (1, 2, 3) • FSH • Galanin (1, 2, 3) • GHB receptor • Gonadotropin-oslobađajući hormon (1, 2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) • Melanokortin (1, 2, 3, 4, 5) • MCHR (1, 2) • Motilin • Opioidni (δ, κ, μ, Nociceptin & ζ, ali ne σ) • Oreksin (1, 2) • Oksitocin • Prokineticin (1, 2) • Prolaktin-oslobađajući peptid • Relaksin (1, 2, 3, 4) • Somatostatin (1, 2, 3, 4, 5) • Tahikinin (1, 2, 3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A, 1B, 2)
Razno
GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Drugi
Adrenomedulin • Mirisni • Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) • Proteazom-aktivirani (1, 2, 3, 4) • SREB (1, 2, 3)
Klasa B: Sekretinu slični
GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Drugi
Klasa C: Metabotropni
glutamat / feromon
TAS1R (1, 2, 3) • TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Drugi
Klasa F:
Frizzled / Zaglađeni
Uvojiti
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)
Zaglađeni
B trdu: peptidi (nrpl/grfl/cytl/horl), receptori (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd, signalni putevi (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)