VUF-6002
Chemical compound
 | |
| Identifiers | |
|---|---|
| |
| CAS Number |
|
| PubChem CID |
|
| IUPHAR/BPS |
|
| ChemSpider |
|
| UNII |
|
| Chemical and physical data | |
| Formula | C13H15ClN4O |
| Molar mass | 278.74 g·mol−1 |
| 3D model (JSmol) |
|
| |
InChI
| |
 N Y (what is this?) (verify) | |
VUF-6002 (JNJ-10191584) is a drug which acts as a potent and selective antagonist at the histamine H4 receptor.[1] It has anti-inflammatory and analgesic effects in animal studies of inflammatory diseases.[2]
See also
- JNJ-7777120 (same molecule but where one nitrogen has been exchanged for a carbon)
References
- ^ Zhang M, Thurmond RL, Dunford PJ (March 2007). "The histamine H(4) receptor: a novel modulator of inflammatory and immune disorders". Pharmacology & Therapeutics. 113 (3): 594–606. doi:10.1016/j.pharmthera.2006.11.008. PMID 17275092.
- ^ Coruzzi G, Adami M, Guaita E, de Esch IJ, Leurs R (June 2007). "Antiinflammatory and antinociceptive effects of the selective histamine H4-receptor antagonists JNJ7777120 and VUF6002 in a rat model of carrageenan-induced acute inflammation". European Journal of Pharmacology. 563 (1–3): 240–4. doi:10.1016/j.ejphar.2007.02.026. PMID 17382315.
- v
- t
- e
Histamine receptor modulators
| Agonists | |
|---|---|
| Antagonists |
|
| Agonists | |
|---|---|
| Antagonists |
|
| Agonists |
|
|---|---|
| Antagonists |
|
- See also
- Receptor/signaling modulators
- Monoamine metabolism modulators
- Monoamine reuptake inhibitors
 | This drug article relating to the musculoskeletal system is a stub. You can help Wikipedia by expanding it. |
- v
- t
- e
