Epinastine
Pair of enantiomers
- C
administration
- R06AX24 (WHO) S01GX10 (WHO)
- (RS)-3-amino-9,13b-dihydro-1H-dibenz(c,f)imidazo(1,5-a)azepine
- 80012-43-7
Y
- 3241
- 7176
- DB00751 Y
- 3128 Y
- Q13WX941EF
- D07900 Y
- CHEBI:51032 Y
- ChEMBL1106 Y
- DTXSID2048371
- Interactive image
- N\4=C(\N3c1c(cccc1)Cc2c(cccc2)C3C/4)N
- InChI=1S/C16H15N3/c17-16-18-10-15-13-7-3-1-5-11(13)9-12-6-2-4-8-14(12)19(15)16/h1-8,15H,9-10H2,(H2,17,18)Y
- Key:WHWZLSFABNNENI-UHFFFAOYSA-NY
Epinastine (brand names Alesion, Elestat, Purivist, Relestat) is a second-generation antihistamine and mast cell stabilizer that is used in eye drops to treat allergic conjunctivitis. It is produced by Allergan and marketed by Inspire in the United States.[1] It is highly selective for the H1 receptor and does not cross the blood-brain-barrier.[2]
It was patented in 1980 and came into medical use in 1994.[3]
References
- ^ Pradhan S, Abhishek K, Mah F (September 2009). "Epinastine: topical ophthalmic second generation antihistamine without significant systemic side effects". Expert Opinion on Drug Metabolism & Toxicology. 5 (9): 1135–1140. doi:10.1517/17425250903117284. PMID 19630694. S2CID 207490591.
- ^ Walther G, Daniel H, Bechtel WD, Brandt K (April 1990). "New tetracyclic guanidine derivatives with H1-antihistaminic properties. Chemistry of epinastine". Arzneimittel-Forschung. 40 (4): 440–446. PMID 1972625.
- ^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 549. ISBN 9783527607495.
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