Bamipine

Chemical compound
  • D04AA15 (WHO) R06AX01 (WHO)
Identifiers
  • N-benzyl-1-methyl-N-phenyl-piperidin-4-amine
CAS Number
  • 4945-47-5 checkY
PubChem CID
  • 72075
ChemSpider
  • 65061 checkY
UNII
  • Y6BHZ28O92
KEGG
  • D07197 checkY
ChEMBL
  • ChEMBL520400 checkY
CompTox Dashboard (EPA)
  • DTXSID5057751 Edit this at Wikidata
ECHA InfoCard100.023.261 Edit this at WikidataChemical and physical dataFormulaC19H24N2Molar mass280.415 g·mol−13D model (JSmol)
  • Interactive image
  • N(c1ccccc1)(Cc2ccccc2)C3CCN(C)CC3
InChI
  • InChI=1S/C19H24N2/c1-20-14-12-19(13-15-20)21(18-10-6-3-7-11-18)16-17-8-4-2-5-9-17/h2-11,19H,12-16H2,1H3 checkY
  • Key:VZSXTYKGYWISGQ-UHFFFAOYSA-N checkY
  (verify)

Bamipine (trade name Soventol)[1] is a pharmaceutical drug acting as an H1 antihistamine with anticholinergic properties.[2] It is used as an antipruritic ointment.[3] No oral use is known.[4]

Adverse effects

Side effects are typical of an old (first-generation) antihistamine: tiredness in adults, agitation in children, mydriasis (dilation of the pupils). These effects are rare when bamipine is applied topically as an ointment. Allergic and hypersensitivity reactions are also rare. Acute eczema can be worsened by bamipine ointment.[5]

Contraindications and interactions

No clinically relevant contraindications or interactions with other drugs are known.[5]

Pharmacology

Pharmacokinetics

When applied topically, the maximal effect is reached after 20 to 60 minutes and lasts up to 48 hours. Bamipine is not absorbed through intact skin in relevant doses.[5]

References

  1. ^ Publishing, William Andrew (2013-10-22). Pharmaceutical Manufacturing Encyclopedia, 3rd Edition. Elsevier. p. 523. ISBN 978-0-8155-1856-3.
  2. ^ Vardanyan RS (2017). "Chapter 5: 4-Substituted and 1,4-Disubstituted Piperidines". Piperidine-based drug discovery. Amsterdam, Netherlands. p. 191. ISBN 978-0-12-813428-3.{{cite book}}: CS1 maint: location missing publisher (link)
  3. ^ WO 0236163, Pairet M, Pieper MP, Meade CJ, Schmelzer C, "Pharmaceutical compositions containing tiotropium salts and antihistamines and their use", published 10 May 2002, assigned to Boehringer Ingelheim 
  4. ^ International Drug Names: Bamipine.
  5. ^ a b c Haberfeld H, ed. (2015). Austria-Codex (in German). Vienna: Österreichischer Apothekerverlag. Soventol-Gel.
  • v
  • t
  • e
Benzimidazoles (*)
Diarylmethanes
Ethylenediamines
Tricyclics
Others
For topical use
  • v
  • t
  • e
mAChRsTooltip Muscarinic acetylcholine receptors
Agonists
Antagonists
Precursors
(and prodrugs)
See also
Receptor/signaling modulators
Nicotinic acetylcholine receptor modulators
Acetylcholine metabolism/transport modulators
  • v
  • t
  • e
nAChRsTooltip Nicotinic acetylcholine receptors
Agonists
(and PAMsTooltip positive allosteric modulators)
Antagonists
(and NAMsTooltip negative allosteric modulators)
Precursors
(and prodrugs)
See also
Receptor/signaling modulators
Muscarinic acetylcholine receptor modulators
Acetylcholine metabolism/transport modulators
  • v
  • t
  • e
H1
Agonists
Antagonists
  • Unknown/unsorted: Azanator
  • Belarizine
  • Elbanizine
  • Flotrenizine
  • GSK1004723
  • Napactadine
  • Tagorizine
  • Trelnarizine
  • Trenizine
H2
Agonists
Antagonists
H3
Agonists
Antagonists
H4
Agonists
Antagonists
See also
Receptor/signaling modulators
Monoamine metabolism modulators
Monoamine reuptake inhibitors