DYRK2

Protein-coding gene in humans
DYRK2
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

3K2L, 3KVW, 4AZF

Identifiers
AliasesDYRK2, dual specificity tyrosine phosphorylation regulated kinase 2
External IDsOMIM: 603496 MGI: 1330301 HomoloGene: 48437 GeneCards: DYRK2
Gene location (Human)
Chromosome 12 (human)
Chr.Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for DYRK2
Genomic location for DYRK2
Band12q15Start67,648,338 bp[1]
End67,665,406 bp[1]
Gene location (Mouse)
Chromosome 10 (mouse)
Chr.Chromosome 10 (mouse)[2]
Chromosome 10 (mouse)
Genomic location for DYRK2
Genomic location for DYRK2
Band10|10 D2Start118,691,508 bp[2]
End118,706,114 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • jejunal mucosa

  • vastus lateralis muscle

  • pylorus

  • biceps brachii

  • visceral pleura

  • right ventricle

  • hair follicle

  • rectum

  • parietal pleura

  • saphenous vein
Top expressed in
  • otolith organ

  • utricle

  • hand

  • knee joint

  • retinal pigment epithelium

  • left colon

  • hair follicle

  • digastric muscle

  • sternocleidomastoid muscle

  • conjunctival fornix
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • transferase activity
  • nucleotide binding
  • protein kinase activity
  • manganese ion binding
  • kinase activity
  • protein binding
  • protein serine/threonine/tyrosine kinase activity
  • protein tyrosine kinase activity
  • ATP binding
  • magnesium ion binding
  • protein serine/threonine kinase activity
Cellular component
  • cytoplasm
  • ubiquitin ligase complex
  • nucleus
  • nucleoplasm
  • cytosol
  • ribonucleoprotein complex
Biological process
  • intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
  • positive regulation of glycogen biosynthetic process
  • phosphorylation
  • cellular response to DNA damage stimulus
  • protein phosphorylation
  • smoothened signaling pathway
  • apoptotic process
  • regulation of signal transduction by p53 class mediator
  • peptidyl-tyrosine phosphorylation
  • negative regulation of calcineurin-NFAT signaling cascade
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

8445

69181

Ensembl

ENSG00000127334

ENSMUSG00000028630

UniProt

Q92630

Q5U4C9

RefSeq (mRNA)

NM_006482
NM_003583

NM_001014390

RefSeq (protein)

NP_003574
NP_006473

NP_001014412

Location (UCSC)Chr 12: 67.65 – 67.67 MbChr 10: 118.69 – 118.71 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Dual specificity tyrosine-phosphorylation-regulated kinase 2 is an enzyme, in particular a dual-specificity kinase, that in humans is encoded by the DYRK2 gene.[5][6]

DYRK2 belongs to a family of protein kinases whose members are presumed to be involved in cellular growth and development. The family is defined by structural similarity of their kinase domains and their capability to autophosphorylate on tyrosine residues. DYRK2 has demonstrated tyrosine autophosphorylation and catalyzed phosphorylation of histones H3 and H2B in vitro. Two isoforms of DYRK2 have been isolated. The predominant isoform, isoform 1, lacks a 5' terminal insert.[6]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000127334 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028630 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Becker W, Weber Y, Wetzel K, Eirmbter K, Tejedor FJ, Joost HG (Nov 1998). "Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinases". J Biol Chem. 273 (40): 25893–902. doi:10.1074/jbc.273.40.25893. PMID 9748265.
  6. ^ a b "Entrez Gene: DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2".

Further reading

  • Woods YL, Cohen P, Becker W, et al. (2001). "The kinase DYRK phosphorylates protein-synthesis initiation factor eIF2Bepsilon at Ser539 and the microtubule-associated protein tau at Thr212: potential role for DYRK as a glycogen synthase kinase 3-priming kinase". Biochem. J. 355 (Pt 3): 609–15. doi:10.1042/bj3550609. PMC 1221774. PMID 11311121.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Wang X, Li W, Parra JL, et al. (2003). "The C Terminus of Initiation Factor 4E-Binding Protein 1 Contains Multiple Regulatory Features That Influence Its Function and Phosphorylation". Mol. Cell. Biol. 23 (5): 1546–57. doi:10.1128/MCB.23.5.1546-1557.2003. PMC 151707. PMID 12588975.
  • Skurat AV, Dietrich AD (2004). "Phosphorylation of Ser640 in muscle glycogen synthase by DYRK family protein kinases". J. Biol. Chem. 279 (4): 2490–8. doi:10.1074/jbc.M301769200. PMID 14593110.
  • Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Taira N, Nihira K, Yamaguchi T, et al. (2007). "DYRK2 is targeted to the nucleus and controls p53 via Ser46 phosphorylation in the apoptotic response to DNA damage". Mol. Cell. 25 (5): 725–38. doi:10.1016/j.molcel.2007.02.007. PMID 17349958.
  • v
  • t
  • e
MAP
  • see MAP kinase pathway
CalciumG protein
Heterotrimeric
cAMP:
cGMP:
Monomeric
CyclinLipidOther protein kinase
Serine/threonine:
Tyrosine:
Serine/threonine/tyrosine
Arginine
Other protein phosphatase
Serine/threonine:
Tyrosine:
both:
Apoptosis
  • see apoptosis signaling pathway
GTP-binding protein regulators
  • see GTP-binding protein regulators
Other
see also deficiencies of intracellular signaling peptides and proteins


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