GNG5

Protein-coding gene in the species Homo sapiens
GNG5
Identifiers
AliasesGNG5, G protein subunit gamma 5
External IDsOMIM: 600874 MGI: 3783217 HomoloGene: 3861 GeneCards: GNG5
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for GNG5
Genomic location for GNG5
Band1p22.3Start84,498,323 bp[1]
End84,506,581 bp[1]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • left ventricle

  • right lung

  • upper lobe of left lung

  • gastrocnemius muscle

  • monocyte

  • body of stomach

  • bone marrow

  • ganglionic eminence

  • body of pancreas

  • spleen
    n/a
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • PDZ domain binding
  • protein binding
  • GTPase activity
  • signal transducer activity
  • G-protein beta-subunit binding
Cellular component
  • extracellular exosome
  • mitochondrion
  • membrane
  • heterotrimeric G-protein complex
  • plasma membrane
  • G-protein beta/gamma-subunit complex
Biological process
  • positive regulation of neural precursor cell proliferation
  • positive regulation of secondary heart field cardioblast proliferation
  • cellular response to glucagon stimulus
  • signal transduction
  • G protein-coupled receptor signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

2787

100043507

Ensembl

ENSG00000174021

n/a

UniProt

P63218

Q80SZ7

RefSeq (mRNA)

NM_005274

n/a

RefSeq (protein)

NP_005265

NP_034448

Location (UCSC)Chr 1: 84.5 – 84.51 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 is a protein that in humans is encoded by the GNG5 gene.[4][5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000174021 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ Ahmad W, Li S, Chen H, Tuck-Muller CM, Pittler SJ, Aronson NN Jr (Aug 1995). "Lysosomal chitobiase (CTB) and the G-protein gamma 5 subunit (GNG5) genes co-localize to human chromosome 1p22". Cytogenet Cell Genet. 71 (1): 44–6. doi:10.1159/000134059. PMID 7606925.
  5. ^ "Entrez Gene: GNG5 guanine nucleotide binding protein (G protein), gamma 5".

Further reading

  • Fisher KJ, Aronson NN (1992). "Characterization of the cDNA and genomic sequence of a G protein gamma subunit (gamma 5)". Mol. Cell. Biol. 12 (4): 1585–91. doi:10.1128/mcb.12.4.1585. PMC 369601. PMID 1549114.
  • Yan K, Kalyanaraman V, Gautam N (1996). "Differential ability to form the G protein betagamma complex among members of the beta and gamma subunit families". J. Biol. Chem. 271 (12): 7141–6. doi:10.1074/jbc.271.12.7141. PMID 8636150.
  • Mao M, Fu G, Wu JS, et al. (1998). "Identification of genes expressed in human CD34+ hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 95 (14): 8175–80. Bibcode:1998PNAS...95.8175M. doi:10.1073/pnas.95.14.8175. PMC 20949. PMID 9653160.
  • Liu B, Aronson NN (1998). "Structure of human G protein G gamma 5 gene GNG5". Biochem. Biophys. Res. Commun. 251 (1): 88–94. doi:10.1006/bbrc.1998.9439. PMID 9790912.
  • Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Cuello F, Schulze RA, Heemeyer F, et al. (2003). "Activation of heterotrimeric G proteins by a high energy phosphate transfer via nucleoside diphosphate kinase (NDPK) B and Gbeta subunits. Complex formation of NDPK B with Gbeta gamma dimers and phosphorylation of His-266 IN Gbeta". J. Biol. Chem. 278 (9): 7220–6. doi:10.1074/jbc.M210304200. PMID 12486123.
  • Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.


  • v
  • t
  • e
MAP
  • see MAP kinase pathway
CalciumG protein
Heterotrimeric
cAMP:
cGMP:
Monomeric
CyclinLipidOther protein kinase
Serine/threonine:
Tyrosine:
Serine/threonine/tyrosine
Arginine
Other protein phosphatase
Serine/threonine:
Tyrosine:
both:
Apoptosis
  • see apoptosis signaling pathway
GTP-binding protein regulators
  • see GTP-binding protein regulators
Other
see also deficiencies of intracellular signaling peptides and proteins


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