GABRQ

Protein-coding gene in humans
GABRQ
Identifiers
AliasesGABRQ, THETA, gamma-aminobutyric acid type A receptor theta subunit, gamma-aminobutyric acid type A receptor subunit theta
External IDsOMIM: 300349 MGI: 1888498 HomoloGene: 10233 GeneCards: GABRQ
Gene location (Human)
X chromosome (human)
Chr.X chromosome (human)[1]
X chromosome (human)
Genomic location for GABRQ
Genomic location for GABRQ
BandXq28Start152,637,895 bp[1]
End152,657,542 bp[1]
Gene location (Mouse)
X chromosome (mouse)
Chr.X chromosome (mouse)[2]
X chromosome (mouse)
Genomic location for GABRQ
Genomic location for GABRQ
BandX|X A7.3Start71,868,784 bp[2]
End71,886,208 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • hypothalamus

  • tibialis anterior muscle

  • amygdala

  • hippocampus proper

  • superior vestibular nucleus

  • canal of the cervix

  • prefrontal cortex

  • nucleus accumbens

  • deltoid muscle

  • tibial nerve
Top expressed in
  • secondary oocyte

  • ventromedial nucleus

  • dorsomedial hypothalamic nucleus

  • arcuate nucleus

  • superior frontal gyrus

  • lateral hypothalamus

  • cerebellar cortex

  • median eminence

  • supraoptic nucleus

  • neural tube
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • GABA-A receptor activity
  • neurotransmitter transmembrane transporter activity
  • chloride channel activity
  • extracellular ligand-gated ion channel activity
  • ion channel activity
  • transmembrane signaling receptor activity
Cellular component
  • integral component of membrane
  • GABA-A receptor complex
  • postsynaptic membrane
  • membrane
  • receptor complex
  • plasma membrane
  • synapse
  • integral component of plasma membrane
  • chloride channel complex
  • cell junction
  • neuron projection
Biological process
  • chloride transmembrane transport
  • ion transport
  • chloride transport
  • signal transduction
  • neurotransmitter transport
  • ion transmembrane transport
  • chemical synaptic transmission
  • regulation of membrane potential
  • nervous system process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

55879

57249

Ensembl

ENSG00000268089

ENSMUSG00000031344

UniProt

Q9UN88

Q9JLF1

RefSeq (mRNA)

NM_018558

NM_001290435
NM_020488

RefSeq (protein)

NP_061028

NP_001277364
NP_065234

Location (UCSC)Chr X: 152.64 – 152.66 MbChr X: 71.87 – 71.89 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Gamma-aminobutyric acid receptor subunit theta is a protein that in humans is encoded by the GABRQ gene.[5][6] The protein encoded by this gene is a subunit of the GABAA receptor.

The θ subunit has highest sequence similarity with the β1 subunit.[6] This subunit coassembles with:

  • α2, β1, and γ1[6]
  • α3 and β1[7]
  • α3, β1, and ε.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000268089 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031344 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Sinkkonen ST, Hanna MC, Kirkness EF, Korpi ER (15 May 2000). "GABA(A) receptor epsilon and theta subunits display unusual structural variation between species and are enriched in the rat locus ceruleus". J. Neurosci. 20 (10): 3588–3595. doi:10.1523/jneurosci.20-10-03588.2000. PMC 6772669. PMID 10804200.
  6. ^ a b c Bonnert TP, McKernan RM, Farrar S, le Bourdellès B, Heavens RP, Smith DW, Hewson L, Rigby MR, Sirinathsinghji DJ, Brown N, Wafford KA, Whiting PJ (August 1999). "θ, a novel γ-aminobutyric acid type A receptor subunit". Proc. Natl. Acad. Sci. U.S.A. 96 (17): 9891–9896. Bibcode:1999PNAS...96.9891B. doi:10.1073/pnas.96.17.9891. PMC 22306. PMID 10449790.
  7. ^ a b Ranna M, Sinkkonen ST, Möykkynen T, Uusi-Oukari M, Korpi ER (2006). "Impact of ε and θ subunits on pharmacological properties of α3β1 GABAA receptors expressed in Xenopus oocytes". BMC Pharmacol. 6: 1. doi:10.1186/1471-2210-6-1. PMC 1363348. PMID 16412217.

Further reading

  • Whiting PJ, Bonnert TP, McKernan RM, et al. (1999). "Molecular and functional diversity of the expanding GABA-A receptor gene family". Ann. N. Y. Acad. Sci. 868 (1): 645–653. Bibcode:1999NYASA.868..645W. doi:10.1111/j.1749-6632.1999.tb11341.x. PMID 10414349. S2CID 13130259.
  • Craddock N, Jones L, Jones IR, et al. (2010). "Strong genetic evidence for a selective influence of GABAA receptors on a component of the bipolar disorder phenotype". Mol. Psychiatry. 15 (2): 146–153. doi:10.1038/mp.2008.66. PMC 3967096. PMID 19078961.
  • Sinkkonen ST, Hanna MC, Kirkness EF, Korpi ER (2000). "GABA(A) receptor epsilon and theta subunits display unusual structural variation between species and are enriched in the rat locus ceruleus". J. Neurosci. 20 (10): 3588–3595. doi:10.1523/jneurosci.20-10-03588.2000. PMC 6772669. PMID 10804200.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Gratacòs M, Costas J, de Cid R, et al. (2009). "Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment". Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6): 808–816. doi:10.1002/ajmg.b.30902. PMID 19086053.
  • Bonnert TP, McKernan RM, Farrar S, et al. (1999). "θ, a novel γ-aminobutyric acid type A receptor subunit". Proc. Natl. Acad. Sci. U.S.A. 96 (17): 9891–9896. Bibcode:1999PNAS...96.9891B. doi:10.1073/pnas.96.17.9891. PMC 22306. PMID 10449790.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Fernandez F, Esposito T, Lea RA, et al. (2008). "Investigation of Gamma-aminobutyric acid (GABA) A receptors genes and migraine susceptibility". BMC Med. Genet. 9: 109. doi:10.1186/1471-2350-9-109. PMC 2615754. PMID 19087248.
  • Tabakoff B, Saba L, Printz M, et al. (2009). "Genetical genomic determinants of alcohol consumption in rats and humans". BMC Biol. 7: 70. doi:10.1186/1741-7007-7-70. PMC 2777866. PMID 19874574.

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