GRIK3

GRIK3
Identifiers
Aliases	GRIK3, EAA5, GLR7, GLUR7, GluK3, GluR7a, glutamate ionotropic receptor kainate type subunit 3
External IDs	OMIM: 138243 MGI: 95816 HomoloGene: 73901 GeneCards: GRIK3
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p34.3 Start 36,795,527 bp[1] End 37,034,515 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 D2.2|4 58.91 cM Start 125,384,493 bp[2] End 125,607,966 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve spinal ganglia trigeminal ganglion prefrontal cortex endothelial cell hypothalamus cingulate gyrus Brodmann area 9 Brodmann area 23 substantia nigra Top expressed in median eminence arcuate nucleus lateral hypothalamus ventromedial nucleus mammillary body paraventricular nucleus of hypothalamus primary motor cortex ventral tegmental area substantia nigra dorsomedial hypothalamic nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function kainate selective glutamate receptor activity adenylate cyclase inhibiting G protein-coupled glutamate receptor activity ion channel activity extracellularly glutamate-gated ion channel activity ligand-gated ion channel activity ionotropic glutamate receptor activity G protein-coupled receptor binding glutamate receptor activity signaling receptor activity ligand-gated ion channel activity involved in regulation of presynaptic membrane potential transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential Cellular component integral component of membrane postsynaptic membrane membrane plasma membrane synapse integral component of plasma membrane cell junction dendrite cytoplasm perikaryon dendrite terminal bouton axon kainate selective glutamate receptor complex presynaptic membrane glutamatergic synapse Biological process G protein-coupled glutamate receptor signaling pathway glutamate receptor signaling pathway ion transport ion transmembrane transport negative regulation of synaptic transmission, glutamatergic ionotropic glutamate receptor signaling pathway adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway regulation of membrane potential excitatory postsynaptic potential synaptic transmission, glutamatergic modulation of chemical synaptic transmission regulation of presynaptic membrane potential regulation of postsynaptic membrane potential Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2899 14807 Ensembl ENSG00000163873 ENSMUSG00000001985 UniProt Q13003 B1AS29 RefSeq (mRNA) NM_000831 NM_001081097 RefSeq (protein) NP_000822 NP_001074566 Location (UCSC) Chr 1: 36.8 – 37.03 Mb Chr 4: 125.38 – 125.61 Mb PubMed search [3] [4]
Wikidata
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Glutamate receptor, ionotropic kainate 3 is a protein that in humans is encoded by the GRIK3 gene.^[5][6]

This gene encodes a protein that belongs to the ligand-gated ionic channel family. It can coassemble with either GRIK4 or GRIK5 to form heteromeric receptors and acts as an excitatory neurotransmitter at many synapses in the central nervous system. RNA editing in the mRNA has been reported.^[6]

See also

• Kainate receptor

References

Further reading

External links

• GRIK3+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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