HTR3E

Protein-coding gene in the species Homo sapiens
HTR3E
Identifiers
AliasesHTR3E, 5-HT3-E, 5-HT3E, 5-HT3c1, 5-hydroxytryptamine receptor 3E
External IDsOMIM: 610123 HomoloGene: 50735 GeneCards: HTR3E
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for HTR3E
Genomic location for HTR3E
Band3q27.1Start184,097,064 bp[1]
End184,106,995 bp[1]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • duodenum

  • placenta

  • rectum

  • right lung

  • prefrontal cortex

  • lymph node

  • appendix

  • monocyte

  • stomach

  • islet of Langerhans
    n/a
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • protein binding
  • extracellular ligand-gated ion channel activity
  • serotonin-gated cation-selective channel activity
  • ion channel activity
  • transmembrane signaling receptor activity
Cellular component
  • integral component of membrane
  • plasma membrane
  • membrane
  • integral component of plasma membrane
  • neuron projection
  • synapse
Biological process
  • ion transport
  • signal transduction
  • ion transmembrane transport
  • serotonin receptor signaling pathway
  • chemical synaptic transmission
  • regulation of membrane potential
  • nervous system process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

285242

n/a

Ensembl

ENSG00000186038

n/a

UniProt

A5X5Y0

n/a

RefSeq (mRNA)

NM_198314
NM_001256613
NM_001256614
NM_182589
NM_198313

n/a

RefSeq (protein)

NP_001243542
NP_001243543
NP_872395
NP_938055
NP_938056

n/a

Location (UCSC)Chr 3: 184.1 – 184.11 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

5-hydroxytryptamine receptor 3E is a protein that in humans is encoded by the HTR3E gene.[3][4] The protein encoded by this gene is a subunit of the 5-HT3 receptor.[4]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000186038 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ Niesler B, Frank B, Kapeller J, Rappold GA (Jun 2003). "Cloning, physical mapping and expression analysis of the human 5-HT3 serotonin receptor-like genes HTR3C, HTR3D and HTR3E". Gene. 310: 101–11. doi:10.1016/S0378-1119(03)00503-1. PMID 12801637.
  4. ^ a b Peters JA, Kelley SP, Dunlop JI, Kirkness EF, Hales TG, Lambert JJ (May 2004). "The 5-hydroxytryptamine type 3 (5-HT3) receptor reveals a novel determinant of single-channel conductance". Biochem Soc Trans. 32 (Pt3): 547–52. doi:10.1042/BST0320547. PMID 15157181.

Further reading

  • Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Karnovsky AM, Gotow LF, McKinley DD, et al. (2003). "A cluster of novel serotonin receptor 3-like genes on human chromosome 3". Gene. 319: 137–48. doi:10.1016/S0378-1119(03)00803-5. PMID 14597179.
  • Nalivaiko E, Sgoifo A (2009). "Central 5-HT receptors in cardiovascular control during stress". Neuroscience and Biobehavioral Reviews. 33 (2): 95–106. doi:10.1016/j.neubiorev.2008.05.026. PMID 18573276. S2CID 44767978.
  • Kapeller J, Houghton LA, Mönnikes H, et al. (2008). "First evidence for an association of a functional variant in the microRNA-510 target site of the serotonin receptor-type 3E gene with diarrhea predominant irritable bowel syndrome". Hum. Mol. Genet. 17 (19): 2967–77. doi:10.1093/hmg/ddn195. PMID 18614545.

External links

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