GABRR3

Protein-coding gene in the species Homo sapiens
GABRR3
Identifiers
AliasesGABRR3, gamma-aminobutyric acid type A receptor rho3 subunit (gene/pseudogene), gamma-aminobutyric acid type A receptor subunit rho3 (gene/pseudogene), gamma-aminobutyric acid type A receptor subunit rho3
External IDsMGI: 3588203 HomoloGene: 26716 GeneCards: GABRR3
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for GABRR3
Genomic location for GABRR3
Band3q11.2Start97,985,102 bp[1]
End98,035,315 bp[1]
Gene location (Mouse)
Chromosome 16 (mouse)
Chr.Chromosome 16 (mouse)[2]
Chromosome 16 (mouse)
Genomic location for GABRR3
Genomic location for GABRR3
Band16|16 C1.3Start59,227,695 bp[2]
End59,284,867 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • islet of Langerhans

  • liver

  • right lobe of liver

  • spleen

  • nucleus accumbens

  • reproductive system

  • reproductive organ

  • gonad

  • male reproductive system

  • testicle
Top expressed in
  • secondary oocyte

  • vasculature

  • spinal cord

  • temporal lobe

  • amygdala

  • brain stem

  • choroid plexus

  • spermatid

  • lens

  • hypothalamus
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • chloride channel activity
  • GABA-A receptor activity
  • extracellular ligand-gated ion channel activity
  • ion channel activity
  • transmembrane signaling receptor activity
  • protein domain specific binding
Cellular component
  • membrane
  • integral component of membrane
  • cell junction
  • GABA-A receptor complex
  • plasma membrane
  • postsynaptic membrane
  • synapse
  • chloride channel complex
  • cellular component
  • integral component of plasma membrane
  • neuron projection
Biological process
  • gamma-aminobutyric acid signaling pathway
  • chloride transport
  • chloride transmembrane transport
  • ion transport
  • chemical synaptic transmission
  • ion transmembrane transport
  • signal transduction
  • regulation of membrane potential
  • nervous system process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

200959

328699

Ensembl

ENSG00000183185

ENSMUSG00000074991

UniProt

A8MPY1

B2RXA8

RefSeq (mRNA)

NM_001105580

NM_001081190

RefSeq (protein)

NP_001099050

NP_001074659

Location (UCSC)Chr 3: 97.99 – 98.04 MbChr 16: 59.23 – 59.28 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Gamma-aminobutyric acid receptor subunit rho-3 is a protein that in humans is encoded by the GABRR3 gene.[5] The protein encoded by this gene is a subunit of the GABAA-ρ receptor.

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000183185 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000074991 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Bailey ME, Albrecht BE, Johnson KJ, Darlison MG (October 1999). "Genetic linkage and radiation hybrid mapping of the three human GABA(C) receptor rho subunit genes: GABRR1, GABRR2 and GABRR3". Biochim. Biophys. Acta. 1447 (2–3): 307–312. doi:10.1016/S0167-4781(99)00167-0. PMID 10542332.

Further reading

  • Croci C, Brändstatter JH, Enz R (2003). "ZIP3, a new splice variant of the PKC-zeta-interacting protein family, binds to GABAC receptors, PKC-zeta, and Kv beta 2". J. Biol. Chem. 278 (8): 6128–6135. doi:10.1074/jbc.M205162200. PMID 12431995.
  • Craddock N, Jones L, Jones IR, et al. (2010). "Strong genetic evidence for a selective influence of GABAA receptors on a component of the bipolar disorder phenotype". Mol. Psychiatry. 15 (2): 146–153. doi:10.1038/mp.2008.66. PMC 3967096. PMID 19078961.
  • Alakuijala A, Palgi M, Wegelius K, et al. (2005). "GABA receptor rho subunit expression in the developing rat brain". Brain Res. Dev. Brain Res. 154 (1): 15–23. doi:10.1016/j.devbrainres.2004.09.010. PMID 15617751.
  • Bailey ME, Albrecht BE, Johnson KJ, Darlison MG (1999). "Genetic linkage and radiation hybrid mapping of the three human GABA(C) receptor rho subunit genes: GABRR1, GABRR2 and GABRR3". Biochim. Biophys. Acta. 1447 (2–3): 307–312. doi:10.1016/S0167-4781(99)00167-0. PMID 10542332.
  • Gratacòs M, Costas J, de Cid R, et al. (2009). "Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment". Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6): 808–816. doi:10.1002/ajmg.b.30902. PMID 19086053. S2CID 44524739.
  • Muzny DM, Scherer SE, Kaul R, et al. (2006). "The DNA sequence, annotation and analysis of human chromosome 3". Nature. 440 (7088): 1194–1198. Bibcode:2006Natur.440.1194M. doi:10.1038/nature04728. PMID 16641997.

External links

  • v
  • t
  • e
Cys-loop receptors
5-HT/serotonin
GABA
  • GABAA
    • α1
    • α2
    • α3
    • α4
    • α5
    • α6
    • β1
    • β2
    • β3
    • γ1
    • γ2
    • γ3
    • δ
    • ε
    • π
    • θ
  • GABAA-ρ
    • ρ1
    • ρ2
    • ρ3
Glycine
  • α1
  • α2
  • α3
  • α4
  • β
Nicotinic acetylcholine
  • pentamers: (α3)2(β4)3
  • (α4)2(β2)3
  • (α7)5
  • (α1)2(β4)3 - Ganglion type
  • (α1)2β1δε - Muscle type
Zinc
Ionotropic glutamates
Ligand-gated only
Voltage- and ligand-gated
‘Orphan’
  • GluD
    • δ1
    • δ2
ATP-gated channels
Purinergic receptors
Stub icon

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

  • v
  • t
  • e