GRINL1A

Protein-coding gene in the species Homo sapiens
POLR2M
Identifiers
AliasesPOLR2M, GCOM1, GRINL1A, Gdown, Gdown1, polymerase (RNA) II subunit M, RNA polymerase II subunit M
External IDsOMIM: 606485 MGI: 107282 HomoloGene: 9181 GeneCards: POLR2M
Gene location (Human)
Chromosome 15 (human)
Chr.Chromosome 15 (human)[1]
Chromosome 15 (human)
Genomic location for POLR2M
Genomic location for POLR2M
Band15q21.3Start57,706,695 bp[1]
End57,782,762 bp[1]
Gene location (Mouse)
Chromosome 9 (mouse)
Chr.Chromosome 9 (mouse)[2]
Chromosome 9 (mouse)
Genomic location for POLR2M
Genomic location for POLR2M
Band9 D|9 39.85 cMStart71,385,719 bp[2]
End71,393,217 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • germinal epithelium

  • Achilles tendon

  • secondary oocyte

  • vena cava

  • optic nerve

  • biceps brachii

  • endometrium

  • seminal vesicula

  • vastus lateralis muscle

  • parietal pleura
Top expressed in
  • somite

  • hand

  • maxillary prominence

  • foot

  • abdominal wall

  • primitive streak

  • atrium

  • dorsomedial hypothalamic nucleus

  • entorhinal cortex

  • superior frontal gyrus
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • DNA-directed 5'-3' RNA polymerase activity
  • protein binding
Cellular component
  • RNA polymerase II, holoenzyme
  • neuronal cell body
  • nuclear envelope
  • nucleus
  • cytoplasm
  • cell junction
  • plasma membrane
  • Z disc
  • cytoskeleton
  • membrane
  • I band
  • cortical actin cytoskeleton
  • extrinsic component of cytoplasmic side of plasma membrane
  • intracellular anatomical structure
Biological process
  • maintenance of ER location
  • RNA biosynthetic process
  • intracellular signal transduction
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

81488

28015

Ensembl

ENSG00000255529

ENSMUSG00000032199

UniProt

P0CAP2
Q6EEV4
P0CAP1

Q6P6I6

RefSeq (mRNA)

NM_001018102
NM_015532

NM_001164793
NM_178602

RefSeq (protein)
NP_001018112
NP_056347
NP_001018112.1
NP_056347.1
NP_001018110

NP_689664

NP_001158265
NP_848717

Location (UCSC)Chr 15: 57.71 – 57.78 MbChr 9: 71.39 – 71.39 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

GRINL1A complex locus protein 1 is a protein that in humans is encoded by the GRINL1A gene.[5]

This gene (GRINL1A) is part of a complex transcript unit that includes the gene for GRINL1A combined protein (Gcom1). Transcription of this gene occurs at a downstream promoter, with at least three different alternatively spliced variants, grouped together as Gdown for GRINL1A downstream transcripts. The Gcom1 gene uses an upstream promoter for transcription and also has multiple alternatively spliced variants.[5]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000255529 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032199 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: GRINL1A glutamate receptor, ionotropic, N-methyl D-aspartate-like 1A".

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
  • Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
  • Roginski RS, Mohan Raj BK, Finkernagel SW, Sciorra LJ (2001). "Assignment of an ionotropic glutamate receptor-like gene (GRINL1A) to human chromosome 15q22.1 by in situ hybridization". Cytogenet. Cell Genet. 93 (1–2): 143–4. doi:10.1159/000056971. PMID 11474202. S2CID 45209253.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Roginski RS, Mohan Raj BK, Birditt B, Rowen L (2005). "The human GRINL1A gene defines a complex transcription unit, an unusual form of gene organization in eukaryotes". Genomics. 84 (2): 265–76. doi:10.1016/j.ygeno.2004.04.004. PMID 15233991.
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.

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