P2RX5

Protein-coding gene in the species Homo sapiens
P2RX5
Identifiers
AliasesP2RX5, LRH-1, P2X5, P2X5R, purinergic receptor P2X 5
External IDsOMIM: 602836 MGI: 2137026 HomoloGene: 1924 GeneCards: P2RX5
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for P2RX5
Genomic location for P2RX5
Band17p13.2Start3,672,199 bp[1]
End3,696,240 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for P2RX5
Genomic location for P2RX5
Band11|11 B4Start73,051,247 bp[2]
End73,063,511 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • spleen

  • lymph node

  • appendix

  • blood

  • gastrocnemius muscle

  • bone marrow cells

  • middle temporal gyrus

  • tibialis anterior muscle

  • nucleus accumbens

  • thymus
Top expressed in
  • brown adipose tissue

  • soleus muscle

  • masseter muscle

  • facial motor nucleus

  • ascending aorta

  • intercostal muscle

  • myocardium of ventricle

  • motor neuron

  • proximal tubule

  • tibialis anterior muscle
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • ion channel activity
  • ATP binding
  • transmembrane signaling receptor activity
  • purinergic nucleotide receptor activity
  • extracellularly ATP-gated cation channel activity
  • ATP-gated ion channel activity
Cellular component
  • integral component of membrane
  • integral component of nuclear inner membrane
  • integral component of plasma membrane
  • membrane
  • plasma membrane
  • cytosol
  • postsynapse
Biological process
  • response to ATP
  • positive regulation of calcium-mediated signaling
  • ion transport
  • positive regulation of calcium ion transport into cytosol
  • cation transmembrane transport
  • signal transduction
  • nervous system development
  • blood coagulation
  • purinergic nucleotide receptor signaling pathway
  • excitatory postsynaptic potential
  • cation transport
  • ion transmembrane transport
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

5026

94045

Ensembl

ENSG00000083454

ENSMUSG00000005950

UniProt

Q93086

n/a

RefSeq (mRNA)

NM_175081
NM_001204519
NM_001204520
NM_002561
NM_175080

NM_033321
NM_001376982
NM_001376983

RefSeq (protein)

NP_001191448
NP_001191449
NP_002552
NP_778255

n/a

Location (UCSC)Chr 17: 3.67 – 3.7 MbChr 11: 73.05 – 73.06 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

P2X purinoceptor 5 is a protein that in humans is encoded by the P2RX5 gene.[5][6]

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel. Several characteristic motifs of ATP-gated channels are present in its primary structure, but, unlike other members of the purinoceptors family, this receptor has only a single transmembrane domain. Four transcript variants encoding distinct isoforms have been identified for this gene.[6]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000083454 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000005950 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Le KT, Paquet M, Nouel D, Babinski K, Seguela P (Jan 1998). "Primary structure and expression of a naturally truncated human P2X ATP receptor subunit from brain and immune system". FEBS Lett. 418 (1–2): 195–9. doi:10.1016/S0014-5793(97)01380-X. PMID 9414125. S2CID 42070561.
  6. ^ a b "Entrez Gene: P2RX5 purinergic receptor P2X, ligand-gated ion channel, 5".

Further reading

  • North RA (2002). "Molecular physiology of P2X receptors". Physiol. Rev. 82 (4): 1013–67. doi:10.1152/physrev.00015.2002. PMID 12270951.
  • Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
  • Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
  • Touchman JW, Anikster Y, Dietrich NL, et al. (2000). "The genomic region encompassing the nephropathic cystinosis gene (CTNS): complete sequencing of a 200-kb segment and discovery of a novel gene within the common cystinosis-causing deletion". Genome Res. 10 (2): 165–73. doi:10.1101/gr.10.2.165. PMC 310836. PMID 10673275.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
  • Greig AV, Linge C, Terenghi G, et al. (2003). "Purinergic receptors are part of a functional signaling system for proliferation and differentiation of human epidermal keratinocytes". J. Invest. Dermatol. 120 (6): 1007–15. doi:10.1046/j.1523-1747.2003.12261.x. PMID 12787128.
  • Greig AV, Linge C, Healy V, et al. (2003). "Expression of purinergic receptors in non-melanoma skin cancers and their functional roles in A431 cells". J. Invest. Dermatol. 121 (2): 315–27. doi:10.1046/j.1523-1747.2003.12379.x. PMID 12880424.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • de Rijke B, van Horssen-Zoetbrood A, Beekman JM, et al. (2006). "A frameshift polymorphism in P2X5 elicits an allogeneic cytotoxic T lymphocyte response associated with remission of chronic myeloid leukemia". J. Clin. Invest. 115 (12): 3506–16. doi:10.1172/JCI24832. PMC 1297240. PMID 16322791.
  • Metcalfe MJ, Baker DM, Burnstock G (2007). "Purinoceptor expression on keratinocytes reflects their function on the epidermis during chronic venous insufficiency". Arch. Dermatol. Res. 298 (6): 301–7. doi:10.1007/s00403-006-0693-x. PMID 16967306. S2CID 11545279.
  • Duckwitz W, Hausmann R, Aschrafi A, Schmalzing G (2007). "P2X5 subunit assembly requires scaffolding by the second transmembrane domain and a conserved aspartate". J. Biol. Chem. 281 (51): 39561–72. doi:10.1074/jbc.M606113200. hdl:2066/130384. PMID 17001079.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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