Protein-coding gene in the species Homo sapiens
| GLRB |
|---|
 |
| Identifiers |
|---|
| Aliases | GLRB, HKPX2, glycine receptor beta |
|---|
| External IDs | OMIM: 138492 MGI: 95751 HomoloGene: 20224 GeneCards: GLRB |
|---|
| Gene location (Human) |
|---|
 | | Chr. | Chromosome 4 (human)[1] |
|---|
| | Band | 4q32.1 | Start | 157,076,125 bp[1] |
|---|
| End | 157,172,090 bp[1] |
|---|
|
| Gene location (Mouse) |
|---|
 | | Chr. | Chromosome 3 (mouse)[2] |
|---|
| | Band | 3 E3|3 35.71 cM | Start | 80,750,906 bp[2] |
|---|
| End | 80,820,967 bp[2] |
|---|
|
| RNA expression pattern |
|---|
| Bgee | | Human | Mouse (ortholog) |
|---|
| Top expressed in | - frontal pole
- Brodmann area 10
- middle frontal gyrus
- pons
- Brodmann area 23
- dorsolateral prefrontal cortex
- endothelial cell
- Brodmann area 9
- superior frontal gyrus
- postcentral gyrus
|
| | Top expressed in | - lateral geniculate nucleus
- mammillary body
- pontine nuclei
- medial vestibular nucleus
- lateral hypothalamus
- dorsal tegmental nucleus
- cerebellar vermis
- medial geniculate nucleus
- medial dorsal nucleus
- ventromedial nucleus
|
| | More reference expression data |
|
|---|
| BioGPS | 
 | | More reference expression data |
|
|---|
|
| Gene ontology |
|---|
| Molecular function | - glycine binding
- protein binding
- extracellularly glycine-gated ion channel activity
- chloride channel activity
- extracellular ligand-gated ion channel activity
- extracellularly glycine-gated chloride channel activity
- ion channel activity
- transmembrane signaling receptor activity
- transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
| | Cellular component | - cytoplasm
- integral component of membrane
- postsynaptic membrane
- cell projection
- membrane
- synapse
- chloride channel complex
- glycine-gated chloride channel complex
- cell junction
- dendrite
- integral component of plasma membrane
- plasma membrane
- GABA-ergic synapse
- glycinergic synapse
- neuron projection
| | Biological process | - response to amino acid
- startle response
- protein heterooligomerization
- regulation of membrane potential
- gamma-aminobutyric acid receptor clustering
- chloride transmembrane transport
- nervous system development
- acrosome reaction
- neuromuscular process
- righting reflex
- chloride transport
- neuropeptide signaling pathway
- visual perception
- adult walking behavior
- ion transport
- synaptic transmission, glycinergic
- excitatory postsynaptic potential
- chemical synaptic transmission
- ion transmembrane transport
- signal transduction
- nervous system process
- regulation of postsynaptic membrane potential
| | Sources:Amigo / QuickGO |
|
| Orthologs |
|---|
| Species | Human | Mouse |
|---|
| Entrez | | |
|---|
| Ensembl | | |
|---|
| UniProt | | |
|---|
| RefSeq (mRNA) | |
|---|
NM_000824
NM_001166060
NM_001166061 |
| NM_001281969
NM_010298
NM_001345955
NM_001345956
NM_001345957
|
|---|
NM_001345958
NM_001345959
NM_001345996 |
|
|---|
| RefSeq (protein) | |
|---|
NP_000815
NP_001159532
NP_001159533 |
| NP_001268898
NP_001332884
NP_001332885
NP_001332886
NP_001332887
|
|---|
NP_001332888
NP_001332925
NP_034428 |
|
|---|
| Location (UCSC) | Chr 4: 157.08 – 157.17 Mb | Chr 3: 80.75 – 80.82 Mb |
|---|
| PubMed search | [3] | [4] |
|---|
|
| Wikidata |
| View/Edit Human | View/Edit Mouse |
|
Glycine receptor subunit beta is a protein that in humans is encoded by the GLRB gene.[5][6][7]
The inhibitory glycine receptor mediates postsynaptic inhibition in the spinal cord and other regions of the central nervous system. It is a pentameric receptor composed of alpha (GLRA1, MIM 138491; GLRA2, MIM 305990) and beta subunits.[supplied by OMIM][7]
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000109738 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028020 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Milani N, Mulhardt C, Weber RG, Lichter P, Kioschis P, Poustka A, Becker CM (Oct 1998). "The human glycine receptor beta subunit gene (GLRB): structure, refined chromosomal localization, and population polymorphism". Genomics. 50 (3): 341–5. doi:10.1006/geno.1998.5324. PMID 9676428.
- ^ Handford CA, Lynch JW, Baker E, Webb GC, Ford JH, Sutherland GR, Schofield PR (Oct 1996). "The human glycine receptor beta subunit: primary structure, functional characterisation and chromosomal localisation of the human and murine genes". Brain Res Mol Brain Res. 35 (1–2): 211–9. doi:10.1016/0169-328x(95)00218-h. PMID 8717357.
- ^ a b "Entrez Gene: GLRB glycine receptor, beta".
Further reading
- Meyer G, Kirsch J, Betz H, Langosch D (1995). "Identification of a gephyrin binding motif on the glycine receptor beta subunit". Neuron. 15 (3): 563–72. doi:10.1016/0896-6273(95)90145-0. PMID 7546736. S2CID 10164739.
- Sarang SS, Miller GW, Grant DF, Schnellmann RG (1999). "Expression and localization of the neuronal glycine receptor beta-subunit in human, rabbit and rat kidneys". Nephron. 82 (3): 254–60. doi:10.1159/000045410. PMID 10395998. S2CID 382638.
- Rees MI, Lewis TM, Kwok JB, et al. (2002). "Hyperekplexia associated with compound heterozygote mutations in the beta-subunit of the human inhibitory glycine receptor (GLRB)". Hum. Mol. Genet. 11 (7): 853–60. doi:10.1093/hmg/11.7.853. PMID 11929858.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Chen Z, Dillon GH, Huang R (2004). "Molecular determinants of proton modulation of glycine receptors". J. Biol. Chem. 279 (2): 876–83. doi:10.1074/jbc.M307684200. PMID 14563849.
- Burzomato V, Groot-Kormelink PJ, Sivilotti LG, Beato M (2004). "Stoichiometry of recombinant heteromeric glycine receptors revealed by a pore-lining region point mutation". Recept. Channels. 9 (6): 353–61. doi:10.3109/714041016. PMID 14698963.
- Harvey K, Duguid IC, Alldred MJ, et al. (2004). "The GDP-GTP exchange factor collybistin: an essential determinant of neuronal gephyrin clustering" (PDF). J. Neurosci. 24 (25): 5816–26. doi:10.1523/JNEUROSCI.1184-04.2004. PMC 6729214. PMID 15215304.
- Grudzinska J, Schemm R, Haeger S, et al. (2005). "The beta subunit determines the ligand binding properties of synaptic glycine receptors". Neuron. 45 (5): 727–39. doi:10.1016/j.neuron.2005.01.028. PMID 15748848. S2CID 2778607.
External links
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
 | This membrane protein–related article is a stub. You can help Wikipedia by expanding it. |
1t3e: Structural basis of dynamic glycine receptor clustering
