Oxetorone

Chemical compound
  • N02CX06 (WHO)
Identifiers
  • (3Z)-3-[1]benzofuro[3,2-c][1]benzoxepin-6(12H)-ylidene-N,N-dimethylpropan-1-amine
CAS Number
  • 26020-55-3 checkY
PubChem CID
  • 6436540
ChemSpider
  • 21173074
UNII
  • T3XOS33TIQ
KEGG
  • D08312 checkY
ECHA InfoCard100.043.086 Edit this at WikidataChemical and physical dataFormulaC21H21NO2Molar mass319.404 g·mol−13D model (JSmol)
  • Interactive image
  • CN(C)CCC=C1C2=CC=CC=C2OCC3=C1OC4=CC=CC=C34
InChI
  • InChI=1S/C21H21NO2/c1-22(2)13-7-10-17-15-8-3-5-11-19(15)23-14-18-16-9-4-6-12-20(16)24-21(17)18/h3-6,8-12H,7,13-14H2,1-2H3
  • Key:VZVRZTZPHOHSCK-UHFFFAOYSA-N
  (verify)

Oxetorone (INNTooltip International Nonproprietary Name), as oxetorone fumarate (USANTooltip United States Adopted Name) (brand names Nocertone, Oxedix), is a serotonin antagonist, antihistamine, and alpha blocker used as an antimigraine drug.[1][2][3][4] Association with hyperprolactinemia has been described[5] and antidopaminergic actions are also suspected.[6]

References

  1. ^ Ganellin CR, Triggle DJ (21 November 1996). Dictionary of Pharmacological Agents. CRC Press. pp. 1493–. ISBN 978-0-412-46630-4.
  2. ^ William Andrew Publishing (22 October 2013). Pharmaceutical Manufacturing Encyclopedia (3rd ed.). Elsevier. pp. 2935–. ISBN 978-0-8155-1856-3.
  3. ^ van Boxtel CJ, Santoso B, Edwards IR (6 August 2008). Drug Benefits and Risks: International Textbook of Clinical Pharmacology (Revised 2nd ed.). IOS Press. pp. 699–. ISBN 978-1-60750-345-3.
  4. ^ Massiou H (2000). "[Prophylactic treatments of migraine]". Revue Neurologique (in French). 156 (Suppl 4): 4S79–86. PMID 11139754.
  5. ^ Pradalier A (December 1996). "Hyperprolactinaemia and depression induced by oxetorone". Cephalalgia. 16 (8): 560–1. doi:10.1046/j.1468-2982.1996.1608560.x. PMID 8980859. S2CID 43533753.
  6. ^ Deguigne M, Bruneau C, Touré A, Turcant A, Le Roux G (February 2017). "New evidence for oxetorone toxicity". Clin Toxicol (Phila). 55 (2): 142–146. doi:10.1080/15563650.2016.1267358. PMID 27967233. S2CID 2137489.


  • v
  • t
  • e
Antimigraine preparations (N02C)
Analgesic/abortive
Serotonergics
Ergolines
5-HT1 agonists
Triptans
Ditans
Others
CGRP-R antagonists
Others
Prophylactic
Calcium channel blockers
Progestogens
Sympatholytics
Tricyclic antidepressants
Anticonvulsants
Anti-CGRP/CGRP-R mAbs
CGRP-R antagonists
  • v
  • t
  • e
α1
Agonists
Antagonists
α2
Agonists
Antagonists
β
Agonists
Antagonists
  • See also: Receptor/signaling modulators
  • Dopaminergics
  • Serotonergics
  • Monoamine reuptake inhibitors
  • Monoamine releasing agents
  • Monoamine metabolism modulators
  • Monoamine neurotoxins
  • v
  • t
  • e
D1-like
Agonists
PAMs
Antagonists
D2-like
Agonists
Antagonists
  • See also: Receptor/signaling modulators
  • Adrenergics
  • Serotonergics
  • Monoamine reuptake inhibitors
  • Monoamine releasing agents
  • Monoamine metabolism modulators
  • Monoamine neurotoxins
  • v
  • t
  • e
H1
Agonists
Antagonists
  • Unknown/unsorted: Azanator
  • Belarizine
  • Elbanizine
  • Flotrenizine
  • GSK1004723
  • Napactadine
  • Tagorizine
  • Trelnarizine
  • Trenizine
H2
Agonists
Antagonists
H3
Agonists
Antagonists
H4
Agonists
Antagonists
See also
Receptor/signaling modulators
Monoamine metabolism modulators
Monoamine reuptake inhibitors
  • v
  • t
  • e
5-HT1
5-HT1A
5-HT1B
5-HT1D
5-HT1E
5-HT1F
5-HT2
5-HT2A
5-HT2B
5-HT2C
5-HT3–7
5-HT3
5-HT4
5-HT5A
5-HT6
5-HT7
  • See also: Receptor/signaling modulators
  • Adrenergics
  • Dopaminergics
  • Melatonergics
  • Monoamine reuptake inhibitors and releasing agents
  • Monoamine metabolism modulators
  • Monoamine neurotoxins
  • v
  • t
  • e
Classes
Antidepressants
(Tricyclic antidepressants (TCAs))
Antihistamines
Antipsychotics
Anticonvulsants
Anticholinergics
Others


Stub icon

This analgesic-related article is a stub. You can help Wikipedia by expanding it.

  • v
  • t
  • e