Prednicarbate

Chemical compound
  • D07AC18 (WHO)
Identifiers
  • 17-[(Ethoxycarbonyl)oxy]-11β-hydroxy-3,20-dioxopregna-1,4-dien-21-yl propionate
CAS Number
  • 73771-04-7 checkY
PubChem CID
  • 6714002
IUPHAR/BPS
  • 7605
DrugBank
  • DB01130 ☒N
ChemSpider
  • 5145991 ☒N
UNII
  • V901LV1K7D
ChEMBL
  • ChEMBL1200386 ☒N
CompTox Dashboard (EPA)
  • DTXSID9045502 Edit this at Wikidata
ECHA InfoCard100.070.516 Edit this at WikidataChemical and physical dataFormulaC27H36O8Molar mass488.577 g·mol−13D model (JSmol)
  • Interactive image
  • O=C(OCC(=O)[C@@]1(OC(=O)OCC)CC[C@H]2[C@H]4[C@H]([C@@H](O)C[C@]12C)[C@]/3(/C=C\C(=O)\C=C\3CC4)C)CC
InChI
  • InChI=1S/C27H36O8/c1-5-22(31)34-15-21(30)27(35-24(32)33-6-2)12-10-19-18-8-7-16-13-17(28)9-11-25(16,3)23(18)20(29)14-26(19,27)4/h9,11,13,18-20,23,29H,5-8,10,12,14-15H2,1-4H3/t18-,19-,20-,23+,25-,26-,27-/m0/s1 ☒N
  • Key:FNPXMHRZILFCKX-KAJVQRHHSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

Prednicarbate is a relatively new topical corticosteroid drug. It is similar in potency to hydrocortisone. Corticosteroids have always been an important part of the pharmacological arsenal of dermatology; however, their tendency to produce side-effects has caused the need to search for new preparations.[1]

It is nonhalogenated.[2]

References

  1. ^ United States Pharmacopeia, the National Formulary. United States Pharmacopeial Convention, Incorporated. 2008. p. 3060. ISBN 978-1-889788-53-1.
  2. ^ Gupta AK, Chow M (2004). "A review of prednicarbate (Dermatop)". Skin Therapy Lett. 9 (10): 5–6, 9. PMID 15657633.
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Glucocorticoids and antiglucocorticoids (D07, H02)
Glucocorticoids
Natural
Synthetic
AntiglucocorticoidsSynthesis modifiers
See also
Glucocorticoid receptor modulators
Mineralocorticoids and antimineralocorticoids
List of corticosteroids
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GRTooltip Glucocorticoid receptor
Agonists
  • Nonsteroidal glucocorticoids: AZD-5423
  • GSK-9027
Mixed
(SEGRMsTooltip Selective glucocorticoid receptor agonists)
Antagonists
Others
  • Antisense oligonucleotides: IONIS-GCCRRx (ISIS-426115)
See also
Receptor/signaling modulators
Glucocorticoids and antiglucocorticoids
Mineralocorticoid receptor modulators
List of corticosteroids


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