NR1H3 |
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Наявні структури |
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PDB | Пошук ортологів: PDBe RCSB | Список кодів PDB | 1UHL, 3IPQ, 3IPS, 3IPU, 5AVI, 5AVL, 5HJS | | |
Ідентифікатори |
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Символи | NR1H3, LXR-a, LXRA, RLD-1, Liver X receptor alpha, nuclear receptor subfamily 1 group H member 3 |
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Зовнішні ІД | OMIM: 602423 MGI: 1352462 HomoloGene: 21165 GeneCards: NR1H3 |
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Пов'язані генетичні захворювання |
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метаболічні захворювання[1] |
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Реагує на сполуку |
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(25R)-cholest-5-ene-3β,26-diol, desmosterol[2] |
Онтологія гена |
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Молекулярна функція | • cholesterol binding • GO:0001948, GO:0016582 protein binding • zinc ion binding • GO:0038050, GO:0004886, GO:0038051 nuclear receptor activity • sterol response element binding • steroid hormone receptor activity • DNA binding • sequence-specific DNA binding • зв'язування з іоном металу • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • GO:0001105 transcription coactivator activity • GO:0000975 transcription cis-regulatory region binding • RNA polymerase II transcription regulatory region sequence-specific DNA binding • transcription factor binding • nuclear receptor coactivator activity • signaling receptor activity |
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Клітинна компонента | • receptor complex • нуклеоплазма • RNA polymerase II transcription regulator complex • клітинне ядро • цитоплазма |
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Біологічний процес | • positive regulation of toll-like receptor 4 signaling pathway • sterol homeostasis • negative regulation of pancreatic juice secretion • negative regulation of inflammatory response • cellular response to lipopolysaccharide • negative regulation of lipid transport • positive regulation of lipoprotein lipase activity • lipid homeostasis • triglyceride homeostasis • negative regulation of macrophage activation • negative regulation of macrophage derived foam cell differentiation • positive regulation of cholesterol transport • negative regulation of cholesterol storage • GO:0009373 regulation of transcription, DNA-templated • positive regulation of triglyceride biosynthetic process • positive regulation of cholesterol efflux • GO:0051247, GO:0051200 positive regulation of protein metabolic process • negative regulation of interferon-gamma-mediated signaling pathway • regulation of circadian rhythm • transcription, DNA-templated • GO:1901227 negative regulation of transcription by RNA polymerase II • response to progesterone • steroid hormone mediated signaling pathway • apoptotic cell clearance • positive regulation of fatty acid biosynthetic process • transcription initiation from RNA polymerase II promoter • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • negative regulation of secretion of lysosomal enzymes • negative regulation of pinocytosis • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • intracellular receptor signaling pathway • cholesterol homeostasis • lipid metabolism • multicellular organism development • диференціація клітин • negative regulation of cold-induced thermogenesis |
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Джерела:Amigo / QuickGO | |
Шаблон експресії |
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Більше даних |
Ортологи |
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Види | Людина | Миша |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (мРНК) | | NM_001130101 NM_001130102 NM_001251934 NM_001251935 NM_005693 |
| | NM_001177730 NM_013839 NM_001355279 |
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RefSeq (білок) | NP_001123573 NP_001123574 NP_001238863 NP_001238864 NP_005684
| NP_001350524 NP_005684.2 |
| | NP_001171201 NP_038867 NP_001342208 |
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Локус (UCSC) | Хр. 11: 47.25 – 47.27 Mb | Хр. 2: 91.01 – 91.03 Mb |
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PubMed search | [3] | [4] |
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Вікідані |
Див./Ред. для людей | Див./Ред. для мишей |
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