TP63 |
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Наявні структури |
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PDB | Пошук ортологів: PDBe RCSB | Список кодів PDB | 4A9Z, 1RG6, 2RMN, 2Y9T, 2Y9U, 3QYM, 3QYN, 3US0, 3US1, 3US2, 3ZY0, 3ZY1 | | |
Ідентифікатори |
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Символи | TP63, AIS, B(p51A), B(p51B), EEC3, KET, LMS, NBP, OFC8, RHS, SHFM4, TP53CP, TP53L, TP73L, p40, p51, p53CP, p63, p73H, p73L, tumor protein p63 |
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Зовнішні ІД | OMIM: 603273 MGI: 1330810 HomoloGene: 31189 GeneCards: TP63 |
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Пов'язані генетичні захворювання |
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adenocarcinoma of the lung, lymphoblastic leukemia, рак легень, ADULT syndrome, Limb–mammary syndrome, ankyloblepharon-ectodermal defects-cleft lip/palate syndrome, split hand-foot malformation 2[1] |
Онтологія гена |
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Молекулярна функція | • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • зв'язування з іоном металу • damaged DNA binding • GO:0001948, GO:0016582 protein binding • WW domain binding • double-stranded DNA binding • DNA binding • sequence-specific DNA binding • identical protein binding • chromatin binding • p53 binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • MDM2/MDM4 family protein binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • protein domain specific binding |
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Клітинна компонента | • цитоплазма • neuron projection • клітинне ядро • rough endoplasmic reticulum • transcription regulator complex • нуклеоплазма • дендрит (нейробіологія) • мітохондрія • комплекс Ґольджі • гіалоплазма • GO:0009327 protein-containing complex |
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Біологічний процес | • pattern specification process • skeletal system development • epithelial cell development • negative regulation of keratinocyte differentiation • epidermal cell division • anatomical structure formation involved in morphogenesis • prostate gland development • transcription by RNA polymerase II • squamous basal epithelial stem cell differentiation involved in prostate gland acinus development • ectoderm and mesoderm interaction • cellular response to DNA damage stimulus • female genitalia morphogenesis • odontogenesis of dentin-containing tooth • prostatic bud formation • positive regulation of cell cycle G1/S phase transition • positive regulation of mesenchymal cell proliferation • Сперматогенез • multicellular organism aging • smooth muscle tissue development • positive regulation of fibroblast apoptotic process • animal organ morphogenesis • hair follicle morphogenesis • positive regulation of Notch signaling pathway • GO:0097285 апоптоз • ремоделювання хроматину • GO:0009373 regulation of transcription, DNA-templated • regulation of neuron apoptotic process • positive regulation of apoptotic signaling pathway • regulation of cysteine-type endopeptidase activity involved in apoptotic process • transcription, DNA-templated • embryonic limb morphogenesis • negative regulation of mesoderm development • epidermis development • post-anal tail morphogenesis • response to gamma radiation • protein homotetramerization • Сигнальний шлях Notch • hair follicle development • neuron apoptotic process • polarized epithelial cell differentiation • proximal/distal pattern formation • диференціація клітин • positive regulation of keratinocyte proliferation • skin morphogenesis • epithelial cell differentiation • urinary bladder development • cellular response to UV • establishment of planar polarity • negative regulation of apoptotic process • GO:1901227 negative regulation of transcription by RNA polymerase II • protein tetramerization • keratinocyte proliferation • positive regulation of osteoblast differentiation • regulation of epidermal cell division • GO:0045996 negative regulation of transcription, DNA-templated • negative regulation of cellular senescence • intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator • sympathetic nervous system development • establishment of skin barrier • morphogenesis of a polarized epithelium • keratinocyte differentiation • multicellular organism development • mitotic G1 DNA damage checkpoint signaling • cloacal septation • response to X-ray • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator • positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway • regulation of signal transduction by p53 class mediator • regulation of apoptotic process • GO:0010260 старіння людини • negative regulation of intracellular estrogen receptor signaling pathway • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • positive regulation of somatic stem cell population maintenance • проліферація • epidermal cell differentiation • embryonic forelimb morphogenesis • embryonic hindlimb morphogenesis • skin epidermis development • cranial skeletal system development • GO:0007571 розвойовий процес |
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Джерела:Amigo / QuickGO | |
Шаблон експресії |
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Більше даних |
Ортологи |
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Види | Людина | Миша |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (мРНК) | NM_001114978 NM_001114979 NM_001114980 NM_001114981 NM_001114982
| NM_003722 NM_001329144 NM_001329145 NM_001329146 NM_001329148 NM_001329149 NM_001329150 NM_001329964 |
| NM_001127259 NM_001127260 NM_001127261 NM_001127262 NM_001127263
| NM_001127264 NM_001127265 NM_011641 |
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RefSeq (білок) | NP_001108450 NP_001108451 NP_001108452 NP_001108453 NP_001108454
| NP_001316073 NP_001316074 NP_001316075 NP_001316077 NP_001316078 NP_001316079 NP_001316893 NP_003713 |
| NP_001120731 NP_001120732 NP_001120733 NP_001120734 NP_001120735
| NP_001120736 NP_001120737 NP_035771 |
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Локус (UCSC) | Хр. 3: 189.63 – 189.9 Mb | Хр. 16: 25.5 – 25.71 Mb |
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PubMed search | [2] | [3] |
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Вікідані |
Див./Ред. для людей | Див./Ред. для мишей |
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