RARA |
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Наявні структури |
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PDB | Пошук ортологів: PDBe RCSB | Список кодів PDB | 1DKF, 1DSZ, 3A9E, 3KMR, 3KMZ, 4DQM, 5K13 | | |
Ідентифікатори |
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Символи | RARA, NR1B1, RAR, retinoic acid receptor alpha, RARalpha |
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Зовнішні ІД | OMIM: 180240 MGI: 97856 HomoloGene: 20262 GeneCards: RARA |
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Реагує на сполуку |
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adapalene, alitretinoin, tamibarotene, tazarotene, третиноїн[1] |
Онтологія гена |
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Молекулярна функція | • retinoic acid binding • GO:0001106 transcription corepressor activity • protein domain specific binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0038050, GO:0004886, GO:0038051 nuclear receptor activity • mRNA 5'-UTR binding • signaling receptor binding • RNA polymerase II transcription regulatory region sequence-specific DNA binding • retinoic acid-responsive element binding • transcription factor binding • зв'язування з іоном металу • steroid hormone receptor activity • enzyme binding • zinc ion binding • GO:0001948, GO:0016582 protein binding • DNA binding • sequence-specific DNA binding • GO:0001105 transcription coactivator activity • protein kinase A binding • protein kinase B binding • translation repressor activity, mRNA regulatory element binding • alpha-actinin binding • protein heterodimerization activity • chromatin DNA binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • histone deacetylase binding • GO:0000975 transcription cis-regulatory region binding • nuclear receptor coactivator activity • signaling receptor activity |
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Клітинна компонента | • цитоплазма • actin cytoskeleton • perinuclear region of cytoplasm • neuron projection • клітинне ядро • cell surface • нуклеоплазма • neuronal cell body • дендрит (нейробіологія) • гіалоплазма • RNA polymerase II transcription regulator complex |
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Біологічний процес | • growth plate cartilage development • germ cell development • cellular response to retinoic acid • ureteric bud development • positive regulation of interleukin-5 production • prostate gland development • limb development • apoptotic cell clearance • chondroblast differentiation • regulation of granulocyte differentiation • protein phosphorylation • response to vitamin A • face development • Сперматогенез • response to ethanol • negative regulation of cell population proliferation • steroid hormone mediated signaling pathway • regulation of apoptotic process • response to cytokine • negative regulation of translation • GO:0009373 regulation of transcription, DNA-templated • negative regulation of cell differentiation • negative regulation of gene expression • transcription, DNA-templated • cellular response to estrogen stimulus • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • positive regulation of cell cycle • regulation of myelination • positive regulation of neuron differentiation • negative regulation of tumor necrosis factor production • transcription initiation from RNA polymerase II promoter • trachea cartilage development • glandular epithelial cell development • male gonad development • negative regulation of cartilage development • response to retinoic acid • negative regulation of granulocyte differentiation • multicellular organism growth • жіноча вагітність • negative regulation of apoptotic process • GO:1901227 negative regulation of transcription by RNA polymerase II • positive regulation of interleukin-4 production • regulation of synaptic plasticity • outflow tract septum morphogenesis • GO:0045996 negative regulation of transcription, DNA-templated • negative regulation of interferon-gamma production • response to estradiol • negative regulation of translational initiation • embryonic camera-type eye development • positive regulation of interleukin-13 production • neural tube closure • positive regulation of binding • retinoic acid receptor signaling pathway • GO:1901313 positive regulation of gene expression • Sertoli cell fate commitment • positive regulation of cell population proliferation • positive regulation of T-helper 2 cell differentiation • ventricular cardiac muscle cell differentiation • liver development • cellular response to lipopolysaccharide • bone development • hippocampus development • GO:0072468 сигнальна трансдукція • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • multicellular organism development • hormone-mediated signaling pathway • диференціація клітин • response to lipid • gland development • bone morphogenesis • epithelium development |
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Джерела:Amigo / QuickGO | |
Шаблон експресії |
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Більше даних |
Ортологи |
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Види | Людина | Миша |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (мРНК) | | NM_000964 NM_001024809 NM_001033603 NM_001145301 NM_001145302 |
| | NM_001176528 NM_001177302 NM_001177303 NM_009024 NM_001361954 |
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RefSeq (білок) | NP_000955 NP_001019980 NP_001138773 NP_001138774 NP_000955.1
| NP_001138773.1 |
| | NP_001169999 NP_001170773 NP_001170774 NP_033050 NP_001348883 |
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Локус (UCSC) | Хр. 17: 40.31 – 40.36 Mb | Хр. 11: 98.82 – 98.87 Mb |
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PubMed search | [2] | [3] |
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Вікідані |
Див./Ред. для людей | Див./Ред. для мишей |
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