CD74 |
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Наявні структури |
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PDB | Пошук ортологів: PDBe RCSB | Список кодів PDB | 1A6A, 1ICF, 1IIE, 1L3H, 1MUJ, 3PDO, 3PGC, 3PGD, 3QXA, 3QXD, 4AEN, 4X5W | | |
Ідентифікатори |
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Символи | CD74, DHLAG, HLADG, II, Ia-GAMMA, CD74 molecule, p33, CLIP |
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Зовнішні ІД | OMIM: 142790 MGI: 96534 HomoloGene: 3209 GeneCards: CD74 |
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Онтологія гена |
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Молекулярна функція | • nitric-oxide synthase binding • identical protein binding • MHC class II protein binding, via antigen binding groove • GO:0016518 cytokine receptor activity • macrophage migration inhibitory factor binding • protein folding chaperone activity • MHC class II protein complex binding • amyloid-beta binding • GO:0001948, GO:0016582 protein binding • MHC class II protein binding • GO:0019974 cytokine binding • CD4 receptor binding |
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Клітинна компонента | • lysosomal lumen • екзосома • MHC class II protein complex • lysosomal membrane • late endosome • endocytic vesicle membrane • transport vesicle membrane • integral component of membrane • ER to Golgi transport vesicle membrane • multivesicular body • комплекс Ґольджі • Golgi membrane • trans-Golgi network membrane • macrophage migration inhibitory factor receptor complex • мембрана • cell surface • внутрішньоклітинний • integral component of lumenal side of endoplasmic reticulum membrane • ендоплазматичний ретикулум • endoplasmic reticulum membrane • клітинна мембрана • лізосома • вакуоля • ендосома • clathrin-coated endocytic vesicle membrane • NOS2-CD74 complex • external side of plasma membrane |
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Біологічний процес | • GO:0046730, GO:0046737, GO:0046738, GO:0046736 імунна відповідь • positive regulation of T cell differentiation • negative regulation of apoptotic process • GO:0072468 сигнальна трансдукція • positive thymic T cell selection • chaperone cofactor-dependent protein refolding • T cell selection • positive regulation of type 2 immune response • positive regulation of dendritic cell antigen processing and presentation • antigen processing and presentation of exogenous peptide antigen via MHC class II • адаптивна імунна відповідь • antigen processing and presentation • positive regulation of peptidyl-tyrosine phosphorylation • negative regulation of mature B cell apoptotic process • regulation of macrophage activation • negative regulation of DNA damage response, signal transduction by p53 class mediator • immunoglobulin mediated immune response • leukocyte migration • positive regulation of neutrophil chemotaxis • positive regulation of chemokine (C-X-C motif) ligand 2 production • macrophage migration inhibitory factor signaling pathway • prostaglandin biosynthetic process • проліферація • antigen processing and presentation of endogenous antigen • процес імунної системи • defense response • negative regulation of peptide secretion • negative regulation of T cell differentiation • positive regulation of macrophage cytokine production • positive regulation of B cell proliferation • negative thymic T cell selection • positive regulation of fibroblast proliferation • intracellular protein transport • positive regulation of ERK1 and ERK2 cascade • negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator • positive regulation of cytokine-mediated signaling pathway • positive regulation of protein phosphorylation • positive regulation of kinase activity • positive regulation of I-kappaB kinase/NF-kappaB signaling • positive regulation of MAPK cascade • positive regulation of monocyte differentiation • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • positive regulation of viral entry into host cell • protein heterotetramerization • protein trimerization • GO:0034622 protein-containing complex assembly |
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Джерела:Amigo / QuickGO | |
Шаблон експресії |
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Більше даних |
Ортологи |
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Види | Людина | Миша |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (мРНК) | | NM_004355 NM_001025158 NM_001025159 NM_001364083 NM_001364084 |
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RefSeq (білок) | | NP_001020329 NP_001020330 NP_004346 NP_001351012 NP_001351013 |
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Локус (UCSC) | Хр. 5: 150.4 – 150.41 Mb | Хр. 18: 60.94 – 60.95 Mb |
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PubMed search | [1] | [2] |
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Вікідані |
Див./Ред. для людей | Див./Ред. для мишей |
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