CXCR4 |
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Наявні структури |
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PDB | Пошук ортологів: PDBe RCSB | Список кодів PDB | 4RWS, 2K03, 2K04, 2K05, 3ODU, 3OE0, 3OE6, 3OE8, 3OE9, 2N55 | | |
Ідентифікатори |
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Символи | CXCR4, CD184, D2S201E, FB22, HM89, HSY3RR, LAP-3, LAP3, LCR1, LESTR, NPY3R, NPYR, NPYRL, NPYY3R, WHIM, WHIMS, C-X-C motif chemokine receptor 4, WHIMS1 |
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Зовнішні ІД | OMIM: 162643 MGI: 109563 HomoloGene: 20739 GeneCards: CXCR4 |
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Пов'язані генетичні захворювання |
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WHIM syndrome[1] |
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Реагує на сполуку |
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plerixafor, mavorixafor[2] |
Онтологія гена |
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Молекулярна функція | • GO:0019974 cytokine binding • coreceptor activity • virus receptor activity • signal transducer activity • GO:0001948, GO:0016582 protein binding • chemokine receptor activity • myosin light chain binding • actin binding • ubiquitin protein ligase binding • G protein-coupled receptor activity • C-X-C chemokine receptor activity • ubiquitin binding • C-C chemokine binding • C-C chemokine receptor activity • chemokine binding • C-X-C motif chemokine 12 receptor activity |
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Клітинна компонента | • цитоплазма • integral component of membrane • ендосома • мембрана • cell surface • міжклітинні контакти • cell leading edge • екзосома • GO:0016023 cytoplasmic vesicle • early endosome • late endosome • лізосома • клітинна мембрана • external side of plasma membrane • GO:0009327 protein-containing complex • клітинне ядро |
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Біологічний процес | • myelin maintenance • positive regulation of oligodendrocyte differentiation • response to hypoxia • positive regulation of cytosolic calcium ion concentration • chemokine-mediated signaling pathway • response to virus • dendritic cell chemotaxis • cellular response to cytokine stimulus • хемотаксис • inflammatory response • calcium-mediated signaling • GO:0072468 сигнальна трансдукція • GO:0097285 апоптоз • GO:0022415 viral process • fusion of virus membrane with host plasma membrane • regulation of chemotaxis • G protein-coupled receptor signaling pathway • axon guidance • GO:0046730, GO:0046737, GO:0046738, GO:0046736 імунна відповідь • brain development • Нейрогенез • CXCL12-activated CXCR4 signaling pathway • cell chemotaxis • positive regulation of cold-induced thermogenesis • regulation of cell adhesion • neuron migration • epithelial cell development • neuron recognition • response to activity • cell migration • telencephalon cell migration • positive regulation of cell migration • positive regulation of vascular wound healing • regulation of programmed cell death • response to morphine • endothelial cell differentiation • positive regulation of neurogenesis • regulation of viral process • positive regulation of chemotaxis • detection of temperature stimulus involved in sensory perception of pain • detection of mechanical stimulus involved in sensory perception of pain • regulation of calcium ion transport • cardiac muscle contraction • endothelial tube morphogenesis • positive regulation of dendrite extension • positive regulation of mesenchymal stem cell migration • response to ultrasound |
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Джерела:Amigo / QuickGO | |
Шаблон експресії |
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Більше даних |
Ортологи |
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Види | Людина | Миша |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (мРНК) | | NM_003467 NM_001008540 NM_001348056 NM_001348059 NM_001348060 |
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RefSeq (білок) | | NP_001008540 NP_003458 NP_001334985 NP_001334988 NP_001334989 |
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Локус (UCSC) | Хр. 2: 136.11 – 136.12 Mb | Хр. 1: 128.52 – 128.52 Mb |
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PubMed search | [3] | [4] |
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Вікідані |
Див./Ред. для людей | Див./Ред. для мишей |
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