IL6R |
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Наявні структури |
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PDB | Пошук ортологів: PDBe RCSB | Список кодів PDB | 1N26, 1P9M, 2ARW | | |
Ідентифікатори |
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Символи | IL6R, CD126, IL-6R-1, IL-6RA, IL6Q, IL6RA, IL6RQ, gp80, Interleukin-6 receptor, interleukin 6 receptor |
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Зовнішні ІД | OMIM: 147880 MGI: 105304 HomoloGene: 474 GeneCards: IL6R |
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Пов'язані генетичні захворювання |
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ревматоїдний артрит, бронхіальна астма, seropositive rheumatoid arthritis[1] |
Онтологія гена |
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Молекулярна функція | • ciliary neurotrophic factor receptor activity • protein homodimerization activity • interleukin-6 receptor binding • GO:0001948, GO:0016582 protein binding • GO:0016518 cytokine receptor activity • enzyme binding • ciliary neurotrophic factor binding • interleukin-6 receptor activity • interleukin-6 binding • interleukin-12 receptor binding • growth factor activity • GO:0019974 cytokine binding • interleukin-12 alpha subunit binding • interleukin-23 receptor binding |
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Клітинна компонента | • integral component of membrane • мембрана • клітинна мембрана • extracellular region • basolateral plasma membrane • apical plasma membrane • interleukin-6 receptor complex • ciliary neurotrophic factor receptor complex • міжклітинний простір • cell surface • external side of plasma membrane • receptor complex • interleukin-12 complex • interleukin-23 complex |
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Біологічний процес | • positive regulation of activation of Janus kinase activity • response to cytokine • hepatic immune response • extrinsic apoptotic signaling pathway • monocyte chemotaxis • ciliary neurotrophic factor-mediated signaling pathway • positive regulation of leukocyte chemotaxis • negative regulation of interleukin-8 production • positive regulation of osteoblast differentiation • GO:0051636 defense response to Gram-negative bacterium • acute-phase response • positive regulation of NF-kappaB transcription factor activity • positive regulation of cell population proliferation • positive regulation of interleukin-6 production • positive regulation of peptidyl-tyrosine phosphorylation • positive regulation of chemokine production • neutrophil mediated immunity • negative regulation of collagen biosynthetic process • endocrine pancreas development • positive regulation of MAPK cascade • positive regulation of smooth muscle cell proliferation • GO:0051637 defense response to Gram-positive bacterium • positive regulation of tyrosine phosphorylation of STAT protein • cytokine-mediated signaling pathway • interleukin-6-mediated signaling pathway • positive regulation of T-helper 1 type immune response • regulation of signaling receptor activity • positive regulation of interferon-gamma production • positive regulation of natural killer cell activation • positive regulation of activated T cell proliferation • positive regulation of lymphocyte proliferation • positive regulation of NK T cell activation • positive regulation of glomerular mesangial cell proliferation |
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Джерела:Amigo / QuickGO | |
Шаблон експресії |
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Більше даних |
Ортологи |
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Види | Людина | Миша |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (мРНК) | | NM_000565 NM_001206866 NM_181359 |
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RefSeq (білок) | NP_000556 NP_001193795 NP_852004 NP_001369698 NP_001369699
| NP_001369700 NP_001369701 NP_001369702 NP_001369703 |
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Локус (UCSC) | Хр. 1: 154.41 – 154.47 Mb | Хр. 3: 89.77 – 89.82 Mb |
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PubMed search | [2] | [3] |
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Вікідані |
Див./Ред. для людей | Див./Ред. для мишей |
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