PDGFRB |
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Наявні структури |
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PDB | Пошук ортологів: PDBe RCSB | Список кодів PDB | 1GQ5, 1H9O, 1SHA, 2L6W, 2PLD, 2PLE, 3MJG | | |
Ідентифікатори |
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Символи | PDGFRB, CD140B, IBGC4, IMF1, JTK12, PDGFR, PDGFR-1, PDGFR1, KOGS, PENTT, platelet derived growth factor receptor beta |
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Зовнішні ІД | OMIM: 173410 MGI: 97531 HomoloGene: 1960 GeneCards: PDGFRB |
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Пов'язані генетичні захворювання |
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гострий мієлоїдний лейкоз, juvenile myelomonocytic leukemia, infantile myofibromatosis, Kosaki overgrowth syndrome, acroosteolysis-keloid-like lesions-premature aging syndrome[1] |
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Реагує на сполуку |
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cediranib, crenolanib, linifanib, Масітиніб, Нінтеданіб, Пазопаніб, semaxanib, сунітиніб, vatalanib, Нінтеданіб, іматиніб, Масітиніб, Бекаплермін, famitinib, orantinib, PD166285, MLN-518, imatinib mesylate[2] |
Онтологія гена |
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Молекулярна функція | • vascular endothelial growth factor binding • kinase activity • platelet-derived growth factor-activated receptor activity • transmembrane receptor protein tyrosine kinase activity • signaling receptor binding • ATP binding • protein kinase activity • platelet-derived growth factor binding • platelet activating factor receptor activity • transferase activity • platelet-derived growth factor receptor binding • GO:0001948, GO:0016582 protein binding • protein tyrosine kinase activity • protein kinase binding • platelet-derived growth factor beta-receptor activity • nucleotide binding • phosphatidylinositol 3-kinase binding • phosphatidylinositol-4,5-bisphosphate 3-kinase activity • enzyme binding |
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Клітинна компонента | • цитоплазма • мембрана • focal adhesion • клітинне ядро • apical plasma membrane • лізосома • екзосома • integral component of membrane • клітинна мембрана • lysosomal lumen • intrinsic component of plasma membrane • GO:0016023 cytoplasmic vesicle • cell surface • комплекс Ґольджі • integral component of plasma membrane • внутрішньоклітинна мембранна органела • receptor complex |
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Біологічний процес | • positive regulation of MAP kinase activity • positive regulation of phospholipase C activity • cell migration involved in vasculogenesis • cardiac myofibril assembly • positive regulation of smooth muscle cell migration • protein phosphorylation • response to lipid • positive regulation of phosphoprotein phosphatase activity • positive regulation of reactive oxygen species metabolic process • metanephric glomerular mesangial cell proliferation involved in metanephros development • positive regulation of ERK1 and ERK2 cascade • cell chemotaxis • inner ear development • metanephric S-shaped body morphogenesis • positive regulation of mitotic nuclear division • platelet-derived growth factor receptor-beta signaling pathway • positive regulation of collagen biosynthetic process • phosphatidylinositol metabolic process • transmembrane receptor protein tyrosine kinase signaling pathway • cell migration involved in coronary angiogenesis • metanephric comma-shaped body morphogenesis • positive regulation of chemotaxis • positive regulation of DNA biosynthetic process • protein autophosphorylation • platelet-derived growth factor receptor signaling pathway • response to toxic substance • positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway • regulation of actin cytoskeleton organization • response to retinoic acid • фосфорилювання • response to hyperoxia • retina vasculature development in camera-type eye • metanephric glomerulus morphogenesis • metanephric mesenchymal cell migration • Загоєння ран • cellular response to platelet-derived growth factor stimulus • negative regulation of apoptotic process • response to fluid shear stress • response to estrogen • хемотаксис • metanephric mesenchyme development • response to hydrogen peroxide • positive regulation of smooth muscle cell proliferation • response to estradiol • GO:0007243 intracellular signal transduction • GO:1904578 response to organic cyclic compound • smooth muscle cell chemotaxis • positive regulation of cell migration • aorta morphogenesis • MAPK cascade • positive regulation of phosphatidylinositol 3-kinase activity • metanephric glomerular capillary formation • multicellular organism development • positive regulation of calcium ion import • glycosaminoglycan biosynthetic process • positive regulation of cell population proliferation • positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway • positive regulation of phosphatidylinositol 3-kinase signaling • peptidyl-tyrosine phosphorylation • cell migration • GO:0072468 сигнальна трансдукція • positive regulation of Rho protein signal transduction • G protein-coupled receptor signaling pathway • phosphatidylinositol phosphate biosynthetic process • positive regulation of hepatic stellate cell activation • positive regulation of fibroblast proliferation • positive regulation of apoptotic process • GO:0010260 старіння людини • male gonad development • lung growth • negative regulation of platelet-derived growth factor receptor-beta signaling pathway • phosphatidylinositol-mediated signaling • positive regulation of protein kinase B signaling • hematopoietic progenitor cell differentiation • positive regulation of MAPK cascade |
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Джерела:Amigo / QuickGO | |
Шаблон експресії |
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Більше даних |
Ортологи |
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Види | Людина | Миша |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (мРНК) | | NM_002609 NM_001355016 NM_001355017 |
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RefSeq (білок) | | NP_002600 NP_001341945 NP_001341946 |
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Локус (UCSC) | Хр. 5: 150.11 – 150.16 Mb | Хр. 18: 61.18 – 61.22 Mb |
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PubMed search | [3] | [4] |
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Вікідані |
Див./Ред. для людей | Див./Ред. для мишей |
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