ERBB2 |
---|
|
Наявні структури |
---|
PDB | Пошук ортологів: PDBe RCSB | Список кодів PDB | 1MFG, 1MFL, 1MW4, 1N8Z, 1QR1, 1S78, 2A91, 2JWA, 2KS1, 2L4K, 3BE1, 3H3B, 3N85, 3PP0, 3RCD, 3MZW, 3WLW, 3WSQ, 4GFU, 4HRL, 4HRM, 4HRN, 2N2A | | |
Ідентифікатори |
---|
Символи | ERBB2, CD340, HER-2, HER-2/neu, HER2, MLN 19, NEU, NGL, TKR1, erb-b2 receptor tyrosine kinase 2 |
---|
Зовнішні ІД | OMIM: 164870 MGI: 95410 HomoloGene: 3273 GeneCards: ERBB2 |
---|
шифр КФ | 2.7.10.1 |
---|
|
Пов'язані генетичні захворювання |
---|
breast carcinoma, disease of cellular proliferation, недрібноклітинна карцинома легенів[1] |
|
Реагує на сполуку |
---|
Афатиніб, canertinib, dacomitinib, лапатиніб, mubritinib, neratinib, Margetuximab, dacomitinib, Пертузумаб, tucatinib, bms-599626, bms-690514, cp-724714, cudc-101, poziotinib, sapitinib, varlitinib, tesevatinib[2] |
Онтологія гена |
---|
Молекулярна функція | • ErbB-3 class receptor binding • transferase activity • nucleotide binding • protein kinase activity • protein dimerization activity • growth factor binding • RNA polymerase I core binding • kinase activity • protein C-terminus binding • GO:0001948, GO:0016582 protein binding • identical protein binding • protein heterodimerization activity • transmembrane receptor protein tyrosine kinase activity • protein tyrosine kinase activity • protein phosphatase binding • ATP binding • transmembrane signaling receptor activity • phosphatidylinositol-4,5-bisphosphate 3-kinase activity • receptor tyrosine kinase |
---|
Клітинна компонента | • integral component of membrane • мембрана • myelin sheath • receptor complex • клітинна мембрана • basolateral plasma membrane • apical plasma membrane • perinuclear region of cytoplasm • endosome membrane • GO:0016023 cytoplasmic vesicle • клітинне ядро • цитоплазма • гіалоплазма • integral component of plasma membrane • basal plasma membrane |
---|
Біологічний процес | • positive regulation of protein phosphorylation • peripheral nervous system development • GO:0009373 regulation of transcription, DNA-templated • negative regulation of immature T cell proliferation in thymus • positive regulation of MAP kinase activity • фосфорилювання • transmembrane receptor protein tyrosine kinase signaling pathway • positive regulation of epithelial cell proliferation • cellular response to growth factor stimulus • Загоєння ран • oligodendrocyte differentiation • regulation of angiogenesis • positive regulation of translation • transcription, DNA-templated • нейробіологія розвитку • MAPK cascade • protein phosphorylation • heart development • cell surface receptor signaling pathway • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity • positive regulation of cell growth • regulation of microtubule-based process • neuromuscular junction development • regulation of ERK1 and ERK2 cascade • myelination • protein autophosphorylation • phosphatidylinositol 3-kinase signaling • positive regulation of transcription by RNA polymerase I • проліферація • positive regulation of transcription by RNA polymerase III • motor neuron axon guidance • enzyme linked receptor protein signaling pathway • GO:0072468 сигнальна трансдукція • positive regulation of cell adhesion • positive regulation of protein targeting to membrane • ERBB2 signaling pathway • phosphatidylinositol phosphate biosynthetic process • GO:1901313 positive regulation of gene expression • peptidyl-tyrosine phosphorylation • regulation of cell motility • cellular response to epidermal growth factor stimulus • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • negative regulation of ERBB signaling pathway • positive regulation of protein kinase B signaling • negative regulation of signal transduction • диференціація клітин • negative regulation of apoptotic process • positive regulation of ERK1 and ERK2 cascade • GO:0007243 intracellular signal transduction • positive regulation of cell population proliferation • neuron differentiation • positive regulation of MAPK cascade |
---|
Джерела:Amigo / QuickGO | |
Шаблон експресії |
---|
|
Більше даних |
Ортологи |
---|
Види | Людина | Миша |
---|
Entrez | | |
---|
Ensembl | | |
---|
UniProt | | |
---|
RefSeq (мРНК) | | NM_001005862 NM_001289936 NM_001289937 NM_001289938 NM_004448 |
| |
---|
RefSeq (білок) | NP_001005862 NP_001276865 NP_001276866 NP_001276867 NP_004439
| NP_001369711 NP_001369712 NP_001369713 NP_001369714 NP_001369715 NP_001369716 NP_001369717 NP_001369718 NP_001369719 NP_001369720 NP_001369721 NP_001369722 NP_001369723 NP_001369724 NP_001369725 NP_001369726 NP_001369727 NP_001369728 NP_001369729 NP_001369730 NP_001369731 NP_001369732 NP_001369733 NP_001369734 NP_001369735 |
| |
---|
Локус (UCSC) | Хр. 17: 39.69 – 39.73 Mb | Хр. 11: 98.3 – 98.33 Mb |
---|
PubMed search | [3] | [4] |
---|
Вікідані |
Див./Ред. для людей | Див./Ред. для мишей |
|