| TNFRSF1A |
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| Наявні структури |
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| PDB | Пошук ортологів: PDBe RCSB |
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| Список кодів PDB | | 1EXT, 1FT4, 1ICH, 1NCF, 1TNR | | |
| Ідентифікатори |
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| Символи | TNFRSF1A, CD120a, FPF, MS5, TBP1, TNF-R, TNF-R-I, TNF-R55, TNFAR, TNFR1, TNFR1-d2, TNFR55, TNFR60, p55, p55-R, p60, tumor necrosis factor receptor superfamily member 1A, TNF receptor superfamily member 1A |
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| Зовнішні ІД | OMIM: 191190 MGI: 1314884 HomoloGene: 828 GeneCards: TNFRSF1A |
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| Пов'язані генетичні захворювання |
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| розсіяний склероз, primary biliary cholangitis, autosomal dominant familial periodic fever[1] |
| Онтологія гена |
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| Молекулярна функція | • GO:0001948, GO:0016582 protein binding
• tumor necrosis factor-activated receptor activity
• tumor necrosis factor binding
• identical protein binding
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| Клітинна компонента | • integral component of membrane
• комплекс Ґольджі
• мембрана
• Golgi membrane
• receptor complex
• клітинна мембрана
• integral component of plasma membrane
• extracellular region
• cell surface
• мітохондрія
• membrane raft
• міжклітинний простір
• tumor necrosis factor receptor superfamily complex
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| Біологічний процес | • regulation of apoptotic process
• prostaglandin metabolic process
• defense response
• positive regulation of ceramide biosynthetic process
• positive regulation of inflammatory response
• regulation of tumor necrosis factor-mediated signaling pathway
• tumor necrosis factor-mediated signaling pathway
• response to lipopolysaccharide
• cellular response to mechanical stimulus
• death-inducing signaling complex assembly
• regulation of cell population proliferation
• defense response to bacterium
• GO:0046730, GO:0046737, GO:0046738, GO:0046736 імунна відповідь
• intrinsic apoptotic signaling pathway in response to DNA damage
• positive regulation of I-kappaB kinase/NF-kappaB signaling
• GO:0022415 viral process
• I-kappaB kinase/NF-kappaB signaling
• negative regulation of inflammatory response
• regulation of establishment of endothelial barrier
• extrinsic apoptotic signaling pathway via death domain receptors
• GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II
• GO:0072468 сигнальна трансдукція
• GO:0097285 апоптоз
• inflammatory response
• cell surface receptor signaling pathway
• positive regulation of tyrosine phosphorylation of STAT protein
• protein localization to plasma membrane
• cytokine-mediated signaling pathway
• aortic valve development
• pulmonary valve development
• negative regulation of extracellular matrix constituent secretion
• negative regulation of cardiac muscle hypertrophy
• positive regulation of apoptotic process involved in morphogenesis
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| Джерела:Amigo / QuickGO | |
| Шаблон експресії |
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| Більше даних |
| Ортологи |
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| Види | Людина | Миша |
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| Entrez | | |
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| Ensembl | | |
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| UniProt | | |
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| RefSeq (мРНК) | | NM_001065
NM_001346091
NM_001346092 |
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| RefSeq (білок) | | NP_001056
NP_001333020
NP_001333021 |
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| Локус (UCSC) | Хр. 12: 6.33 – 6.34 Mb | Хр. 6: 125.33 – 125.34 Mb |
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| PubMed search | [2] | [3] |
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| Вікідані |
| Див./Ред. для людей | Див./Ред. для мишей |
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