CLCA1

Protein-coding gene in the species Homo sapiens

CLCA1

Identifiers

Aliases

CLCA1, CACC, CACC1, CLCRG1, CaCC-1, GOB5, hhCaCC-1, chloride channel accessory 1

External IDs

OMIM: 603906 MGI: 1346342 HomoloGene: 984 GeneCards: CLCA1

Gene location (Human)

Chr.	Chromosome 1 (human)^[1]

Band	1p22.3	Start	86,468,368 bp^[1]
Band	1p22.3	End	86,500,259 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 3 (mouse)^[2]

Band	3 H2\|3 69.26 cM	Start	144,709,578 bp^[2]
Band	3 H2\|3 69.26 cM	End	144,738,537 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

jejunal mucosa

rectum

duodenum

cecum

appendix

pancreatic ductal cell

smooth muscle tissue

amniotic fluid

bronchial epithelial cell

pylorus

Top expressed in

left colon

intestinal villus

cervix

pyloric antrum

ileum

duodenum

mucous cell of stomach

crypt of lieberkuhn of small intestine

jejunum

epithelium of stomach

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	metal ion binding peptidase activity hydrolase activity chloride channel activity metallopeptidase activity metalloendopeptidase activity intracellular calcium activated chloride channel activity
Cellular component	extracellular region integral component of membrane integral component of plasma membrane microvillus zymogen granule membrane membrane plasma membrane secretory granule extracellular space
Biological process	calcium ion transport proteolysis chloride transport ion transport ion transmembrane transport cellular response to hypoxia chloride transmembrane transport
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


1179


23844

Ensembl


ENSG00000016490


ENSMUSG00000028255

UniProt


A8K7I4


Q9D7Z6

RefSeq (mRNA)


NM_001285


NM_017474

RefSeq (protein)


NP_001276


NP_059502

Location (UCSC)

Chr 1: 86.47 – 86.5 Mb

Chr 3: 144.71 – 144.74 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Chloride channel accessory 1 is a protein that in humans is encoded by the CLCA1 gene.^[5]^[6]

This gene encodes a member of the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same region on chromosome 1p31-p22 and share a high degree of homology in size, sequence, and predicted structure, but differ significantly in their tissue distributions. The encoded protein is expressed as a precursor protein that is processed into two cell-surface-associated subunits, although the site at which the precursor is cleaved has not been precisely determined. The encoded protein may be involved in mediating calcium-activated chloride conductance in the intestine.^[6] Protein structure prediction methods suggest the N-terminal region of CLCA1 protein is a zinc metalloprotease.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000016490 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028255 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Gruber AD, Elble RC, Ji HL, Schreur KD, Fuller CM, Pauli BU (Jan 1999). "Genomic cloning, molecular characterization, and functional analysis of human CLCA1, the first human member of the family of Ca²⁺-activated Cl⁻ channel proteins". Genomics. 54 (2): 200–14. doi:10.1006/geno.1998.5562. PMID 9828122.
^ ^a ^b "Entrez Gene: CLCA1 chloride channel, calcium activated, family member 1".
^ Pawłowski K, Lepistö M, Meinander N, et al. (2006). "Novel conserved hydrolase domain in the CLCA family of alleged calcium-activated chloride channels". Proteins. 63 (3): 424–39. doi:10.1002/prot.20887. PMID 16470849. S2CID 40041491.

External links

CLCA1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Human CLCA1 genome location and CLCA1 gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Membrane transport protein: ion channels (TC 1A)

Ca²⁺: Calcium channel

Ligand-gated	Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3
Voltage-gated	L-type/Ca_vα 1.1 1.2 1.3 1.4 N-type/Ca_vα2.2 P-type/Ca_vα 2.1 Q-type/Ca_vα2.1 R-type/Ca_vα2.3 T-type/Ca_vα 3.1 3.2 3.3 α₂δ-subunits 1 2 β-subunits β1 β2 β3 β4 γ-subunits γ1 γ2 γ3 γ4 Cation channels of sperm 1 2 3 4 Two-pore channel 1 2

Na⁺: Sodium channel

Constitutively active	Epithelial sodium channel α β γ δ
Proton-gated	Amiloride-sensitive cation channel 1 2 3 4
Voltage-gated	Na_vα 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 7A Na_vβ 1 2 3 4

K⁺: Potassium channel

Calcium-activated	BK channel α1 β1 β2 β3 β4 SK channel SK1 SK2 SK3 IK channel IK1 K_Ca 1.1 2.1 2.2 2.3 3.1 4.1 4.2 5.1
Inward-rectifier	K_ATP K_ir 1.1 2.1 2.2 2.3 2.4 2.6 GIRK/K_ir 3.1 3.2 3.3 3.4 K_ir 4.1 4.2 5.1 6.1 6.2 7.1
Tandem pore domain	K2P 1 2 3 4 5 6 7 9 10 12 13 15 16 17 18
Voltage-gated	K_vα1-6 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 2.1 2.2 3.1 3.2 3.3 3.4 4.1 4.2 4.3 5.1 6.1 6.2 6.3 6.4 K_vα7-12 7.1 7.2 7.3 7.4 7.5 8.1 8.2 9.1 9.2 9.3 10.1 10.2 11.1/hERG 11.2 11.3 12.1 12.2 12.3 K_vβ 1 2 3 KCNIP 1 2 3 4 minK/ISK minK/ISK-like MiRP 1 2 3 Shaker (gene)

Miscellaneous

Cl⁻: Chloride channel	Calcium-activated chloride channels Anoctamin ANO1 Bestrophin 1 2 Chloride Channel Accessory 1 2 3 4 CFTR CLCN 1 2 3 4 5 6 7 KA KB CLIC 1 2 3 4 5 6 L1 CLNS 1A 1B
H⁺: Proton channel	HVCN1
M⁺: CNG cation channel	α 1 2 3 4 β 1 2 3 HCN FC 1 2 3 4
M⁺: TRP cation channel	TRPA (1) TRPC 1 2 3 4 4AP 5 6 7 TRPM 1 2 3 4 5 6 7 8 TRPML 1 2 3 TRPN TRPP 1 2 TRPV 1 2 3 4 5 6
H₂O (+ solutes): Porin	Aquaporin 0 1 2 3 4 5 6 7 8 9 Voltage-dependent anion channel 1 2 3 General bacterial porin family
Cytoplasm: Gap junction	Connexin A GJA1 GJA3 GJA4 GJA5 GJA8 GJA9 GJA10 B GJB1 GJB2 GJB3 GJB4 GJB5 GJB6 GJB7 C GJC1 GJC2 GJC3 D GJD2 GJD3 GJD4 Innexin