MCOLN2

MCOLN2
Identifiers
Aliases	MCOLN2, TRP-ML2, TRPML2, mucolipin 2, mucolipin TRP cation channel 2
External IDs	OMIM: 607399 MGI: 1915529 HomoloGene: 12258 GeneCards: MCOLN2
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p22.3 Start 84,925,583 bp[1] End 84,997,113 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 H2 Start 145,855,588 bp[2] End 145,901,268 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibia rectum lymph node left adrenal gland secondary oocyte spleen right uterine tube germinal epithelium upper lobe of left lung appendix Top expressed in yolk sac duodenum spleen jejunum colon left colon spermatid Paneth cell blood crypt of lieberkuhn of small intestine More reference expression data BioGPS n/a
Gene ontology Molecular function calcium channel activity cation channel activity NAADP-sensitive calcium-release channel activity Cellular component integral component of membrane membrane lysosome lysosomal membrane endosome plasma membrane late endosome membrane recycling endosome membrane recycling endosome Biological process ion transport adaptive immune response immune system process calcium ion transport protein transport innate immune response calcium ion transmembrane transport positive regulation of chemokine production protein complex oligomerization positive regulation of monocyte chemotactic protein-1 production positive regulation of macrophage inflammatory protein 1 alpha production positive regulation of chemokine (C-C motif) ligand 5 production macrophage migration neutrophil migration positive regulation of chemokine (C-X-C motif) ligand 2 production release of sequestered calcium ion into cytosol Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 255231 68279 Ensembl ENSG00000153898 ENSMUSG00000011008 UniProt Q8IZK6 Q8K595 RefSeq (mRNA) NM_153259 NM_001330647 NM_001005846 NM_026656 RefSeq (protein) NP_001317576 NP_694991 NP_001005846 NP_080932 Location (UCSC) Chr 1: 84.93 – 85 Mb Chr 3: 145.86 – 145.9 Mb PubMed search [3] [4]
Wikidata
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Mucolipin-2 also known as TRPML2 (transient receptor potential cation channel, mucolipin subfamily, member 2) is a protein that in humans is encoded by the MCOLN2 gene.^[5] It is a member of the small family of the TRPML channels, a subgroup of the large protein family of TRP ion channels.

TRPML2 is associated with the Arf6-regulated trafficking pathway and is involved in the intracellular transport of membranes and membrane proteins.^[6]

See also

• transient receptor potential cation channel, mucolipin subfamily, member 1 (MCOLN1)
• transient receptor potential cation channel, mucolipin subfamily, member 3 (MCOLN3)
• TRPML

References

External links

• MCOLN2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

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