ITPR3

Protein-coding gene in the species Homo sapiens
ITPR3
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

3JRR

Identifiers
AliasesITPR3, IP3R, IP3R3, inositol 1,4,5-trisphosphate receptor type 3
External IDsOMIM: 147267 MGI: 96624 HomoloGene: 1675 GeneCards: ITPR3
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for ITPR3
Genomic location for ITPR3
Band6p21.31Start33,620,365 bp[1]
End33,696,574 bp[1]
Gene location (Mouse)
Chromosome 17 (mouse)
Chr.Chromosome 17 (mouse)[2]
Chromosome 17 (mouse)
Genomic location for ITPR3
Genomic location for ITPR3
Band17 A3.3|17 13.68 cMStart27,276,278 bp[2]
End27,341,197 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • pylorus

  • trigeminal ganglion

  • sural nerve

  • olfactory bulb

  • left lobe of thyroid gland

  • spinal ganglia

  • right lobe of thyroid gland

  • cardia

  • skin of abdomen

  • pancreatic ductal cell
Top expressed in
  • molar

  • pyloric antrum

  • epithelium of stomach

  • mucous cell of stomach

  • lip

  • sciatic nerve

  • rib

  • left colon

  • ileum

  • intestinal villus
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • calcium channel activity
  • inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
  • ion channel activity
  • protein binding
  • inositol 1,3,4,5 tetrakisphosphate binding
  • calcium-release channel activity
  • inositol hexakisphosphate binding
  • inositol 1,4,5 trisphosphate binding
  • calcium ion binding
  • phosphatidylinositol binding
Cellular component
  • cytoplasm
  • integral component of membrane
  • endoplasmic reticulum membrane
  • membrane
  • receptor complex
  • plasma membrane
  • apical part of cell
  • integral component of plasma membrane
  • nucleoplasm
  • nucleolus
  • platelet dense tubular network membrane
  • endoplasmic reticulum
  • brush border
  • nucleus
  • nuclear outer membrane
  • myelin sheath
  • neuronal cell body
  • sarcoplasmic reticulum
  • cytoplasmic vesicle membrane
  • secretory granule membrane
Biological process
  • sensory perception of umami taste
  • calcium ion transport into cytosol
  • regulation of cardiac conduction
  • regulation of insulin secretion
  • memory
  • ion transport
  • platelet activation
  • response to calcium ion
  • sensory perception of bitter taste
  • calcium ion transmembrane transport
  • transmembrane transport
  • sensory perception of sweet taste
  • inositol phosphate-mediated signaling
  • calcium ion transport
  • long-term potentiation
  • G protein-coupled receptor signaling pathway
  • positive regulation of cytosolic calcium ion concentration
  • protein homooligomerization
  • protein heterooligomerization
  • release of sequestered calcium ion into cytosol
  • transport
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

3710

16440

Ensembl

ENSG00000096433

ENSMUSG00000042644

UniProt

Q14573

P70227

RefSeq (mRNA)

NM_002224

NM_080553

RefSeq (protein)

NP_002215

NP_542120

Location (UCSC)Chr 6: 33.62 – 33.7 MbChr 17: 27.28 – 27.34 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Inositol 1,4,5-trisphosphate receptor, type 3, also known as ITPR3, is a protein which in humans is encoded by the ITPR3 gene.[5] The protein encoded by this gene is both a receptor for inositol triphosphate and a calcium channel.[6]

Function

ITP3 channels serve an important role in the taste transduction pathway of sweet, bitter and umami tastes the gustatory system. ITP3 channels allow the flow of Calcium out of the endoplasmic reticulum in response to IP3. Calcium cations result in the activation of TRPM5 which leads to a depolarisation generating potential and an action potential.[7]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000096433 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000042644 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: inositol 1".
  6. ^ Yamamoto-Hino M, Sugiyama T, Hikichi K, et al. (1994). "Cloning and characterization of human type 2 and type 3 inositol 1,4,5-trisphosphate receptors". Recept. Channels. 2 (1): 9–22. PMID 8081734.
  7. ^ Chaudhari N, Roper SD (August 2010). "The cell biology of taste". J. Cell Biol. 190 (3): 285–96. doi:10.1083/jcb.201003144. PMC 2922655. PMID 20696704.

Further reading

  • Kline CF, Cunha SR, Lowe JS, et al. (2008). "Revisiting ankyrin-InsP3 receptor interactions: ankyrin-B associates with the cytoplasmic N-terminus of the InsP3 receptor". J. Cell. Biochem. 104 (4): 1244–53. doi:10.1002/jcb.21704. PMC 2858327. PMID 18275062.
  • Oishi T, Iida A, Otsubo S, et al. (2008). "A functional SNP in the NKX2.5-binding site of ITPR3 promoter is associated with susceptibility to systemic lupus erythematosus in Japanese population". J. Hum. Genet. 53 (2): 151–62. doi:10.1007/s10038-007-0233-3. PMID 18219441.
  • Hirose M, Stuyvers B, Dun W, et al. (2008). "Wide long lasting perinuclear Ca2+ release events generated by an interaction between ryanodine and IP3 receptors in canine Purkinje cells". J. Mol. Cell. Cardiol. 45 (2): 176–84. doi:10.1016/j.yjmcc.2008.05.008. PMC 2566512. PMID 18586264.
  • Miyachi K, Iwai M, Asada K, et al. (2007). "Inositol 1,4,5-trisphosphate receptors are autoantibody target antigens in patients with Sjögren's syndrome and other systemic rheumatic diseases". Mod Rheumatol. 17 (2): 137–43. doi:10.1007/s10165-006-0555-6. PMID 17437169. S2CID 36516047.
  • Tang TS, Guo C, Wang H, et al. (2009). "Neuroprotective effects of inositol 1,4,5-trisphosphate receptor C-terminal fragment in a Huntington's disease mouse model". J. Neurosci. 29 (5): 1257–66. doi:10.1523/JNEUROSCI.4411-08.2009. PMC 2768402. PMID 19193873.
  • Nagaleekar VK, Diehl SA, Juncadella I, et al. (2008). "IP3 receptor-mediated Ca2+ release in naive CD4 T cells dictates their cytokine program". J. Immunol. 181 (12): 8315–22. doi:10.4049/jimmunol.181.12.8315. PMC 2756541. PMID 19050248.
  • Bandyopadhyay BC, Swaim WD, Liu X, et al. (2005). "Apical localization of a functional TRPC3/TRPC6-Ca2+-signaling complex in polarized epithelial cells. Role in apical Ca2+ influx". J. Biol. Chem. 280 (13): 12908–16. doi:10.1074/jbc.M410013200. PMID 15623527.
  • Kasri NN, Holmes AM, Bultynck G, et al. (2004). "Regulation of InsP3 receptor activity by neuronal Ca2+-binding proteins". EMBO J. 23 (2): 312–21. doi:10.1038/sj.emboj.7600037. PMC 1271747. PMID 14685260.
  • Hattori M, Suzuki AZ, Higo T, et al. (2004). "Distinct roles of inositol 1,4,5-trisphosphate receptor types 1 and 3 in Ca2+ signaling". J. Biol. Chem. 279 (12): 11967–75. doi:10.1074/jbc.M311456200. PMID 14707143.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
  • Roach JC, Deutsch K, Li S, et al. (2006). "Genetic mapping at 3-kilobase resolution reveals inositol 1,4,5-triphosphate receptor 3 as a risk factor for type 1 diabetes in Sweden". Am. J. Hum. Genet. 79 (4): 614–27. doi:10.1086/507876. PMC 1592562. PMID 16960798.
  • Tojyo Y, Morita T, Nezu A, Tanimura A (2008). "The clustering of inositol 1,4,5-trisphosphate (IP(3)) receptors is triggered by IP(3) binding and facilitated by depletion of the Ca2+ store". J. Pharmacol. Sci. 107 (2): 138–50. doi:10.1254/jphs.08021FP. PMID 18544901.
  • Singleton PA, Bourguignon LY (2004). "CD44 interaction with ankyrin and IP3 receptor in lipid rafts promotes hyaluronan-mediated Ca2+ signaling leading to nitric oxide production and endothelial cell adhesion and proliferation". Exp. Cell Res. 295 (1): 102–18. doi:10.1016/j.yexcr.2003.12.025. PMID 15051494.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Ogasawara H (2008). "The calcium kinetics and inositol trisphosphate receptor properties shape the asymmetric timing window of coincidence detection". J. Neurosci. 28 (17): 4293–4. doi:10.1523/JNEUROSCI.0644-08.2008. PMC 6670947. PMID 18434505.
  • Qu HQ, Marchand L, Szymborski A, et al. (2008). "The association between type 1 diabetes and the ITPR3 gene polymorphism due to linkage disequilibrium with HLA class II". Genes Immun. 9 (3): 264–6. doi:10.1038/gene.2008.12. PMID 18340361. S2CID 8563179.
  • Wu Z, Bowen WD (2008). "Role of sigma-1 receptor C-terminal segment in inositol 1,4,5-trisphosphate receptor activation: constitutive enhancement of calcium signaling in MCF-7 tumor cells". J. Biol. Chem. 283 (42): 28198–215. doi:10.1074/jbc.M802099200. PMC 2661391. PMID 18539593.
  • Martínez-Gámez A, Dent MA (2007). "Expression of IP3 receptor isoforms at the nodes of Ranvier in rat sciatic nerve". NeuroReport. 18 (5): 447–50. doi:10.1097/WNR.0b013e32805868a6. PMID 17496801. S2CID 28136973.
  • Garcia-Elias A, Lorenzo IM, Vicente R, Valverde MA (2008). "IP3 receptor binds to and sensitizes TRPV4 channel to osmotic stimuli via a calmodulin-binding site". J. Biol. Chem. 283 (46): 31284–8. doi:10.1074/jbc.C800184200. PMID 18826956.
  • Sundivakkam PC, Kwiatek AM, Sharma TT, et al. (2009). "Caveolin-1 scaffold domain interacts with TRPC1 and IP3R3 to regulate Ca2+ store release-induced Ca2+ entry in endothelial cells". Am. J. Physiol., Cell Physiol. 296 (3): C403–13. doi:10.1152/ajpcell.00470.2008. PMC 2660268. PMID 19052258.

External links

  • v
  • t
  • e
Ligand-gated
Voltage-gated
Constitutively active
Proton-gated
Voltage-gated
Calcium-activated
Inward-rectifier
Tandem pore domain
Voltage-gated
Miscellaneous
Cl−: Chloride channel
H+: Proton channel
M+: CNG cation channel
M+: TRP cation channel
H2O (+ solutes): Porin
Cytoplasm: Gap junction
By gating mechanism
Ion channel class
see also disorders


Stub icon

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

  • v
  • t
  • e