Protein-coding gene in humans
| CLIC2 |
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| Available structures |
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| PDB | Human UniProt search: PDBe RCSB |
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| List of PDB id codes |
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2PER, 2R4V, 2R5G |
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| Identifiers |
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| Aliases | CLIC2, CLIC2b, MRXS32, XAP121, chloride intracellular channel 2, CLCNL2 |
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| External IDs | OMIM: 300138 HomoloGene: 48010 GeneCards: CLIC2 |
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| Gene location (Human) |
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 | | Chr. | X chromosome (human)[1] |
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| | Band | Xq28 | Start | 155,276,211 bp[1] |
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| End | 155,334,657 bp[1] |
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| RNA expression pattern |
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| Bgee | | Human | Mouse (ortholog) |
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| Top expressed in | - Achilles tendon
- right lung
- spleen
- upper lobe of left lung
- gallbladder
- superficial temporal artery
- lymph node
- left lobe of thyroid gland
- right lobe of thyroid gland
- subcutaneous adipose tissue
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| | | More reference expression data |
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| BioGPS |  | | More reference expression data |
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| Gene ontology |
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| Molecular function | - glutathione transferase activity
- voltage-gated ion channel activity
- glutathione peroxidase activity
- protein binding
- chloride channel activity
| | Cellular component | - cytoplasm
- integral component of membrane
- membrane
- intracellular anatomical structure
- chloride channel complex
- nucleus
| | Biological process | - regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
- regulation of ion transmembrane transport
- ion transport
- negative regulation of ryanodine-sensitive calcium-release channel activity
- positive regulation of binding
- chloride transport
- regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
- signal transduction
- cellular oxidant detoxification
- glutathione metabolic process
- chloride transmembrane transport
| | Sources:Amigo / QuickGO |
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| Orthologs |
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| Species | Human | Mouse |
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| Entrez | | |
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| Ensembl | | |
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| UniProt | | |
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| RefSeq (mRNA) | | |
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| RefSeq (protein) | | |
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| Location (UCSC) | Chr X: 155.28 – 155.33 Mb | n/a |
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| PubMed search | [2] | n/a |
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| Wikidata |
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Chloride intracellular channel protein 2 is a protein that in humans is encoded by the CLIC2 gene.[3][4]
Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 2 is a member of the p64 family; the protein is detected in fetal liver and adult skeletal muscle tissue. This gene maps to the candidate region on chromosome X for incontinentia pigmenti.[4]
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000155962 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Heiss NS, Poustka A (Nov 1997). "Genomic structure of a novel chloride channel gene, CLIC2, in Xq28". Genomics. 45 (1): 224–8. doi:10.1006/geno.1997.4922. PMID 9339381.
- ^ a b "Entrez Gene: CLIC2 chloride intracellular channel 2".
Further reading
- Thiemann A, Gründer S, Pusch M, Jentsch TJ (1992). "A chloride channel widely expressed in epithelial and non-epithelial cells". Nature. 356 (6364): 57–60. Bibcode:1992Natur.356...57T. doi:10.1038/356057a0. PMID 1311421. S2CID 4254798.
- Rogner UC, Heiss NS, Kioschis P, et al. (1997). "Transcriptional analysis of the candidate region for incontinentia pigmenti (IP2) in Xq28". Genome Res. 6 (10): 922–34. doi:10.1101/gr.6.10.922. PMID 8908511.
- Singh H (2010). "Two decades with dimorphic Chloride Intracellular Channels (CLICs)". FEBS Letters. 584 (10): 2112–21. doi:10.1016/j.febslet.2010.03.013. PMID 20226783. S2CID 21056278.
- Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
- Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Dhani SU, Mohammad-Panah R, Ahmed N, et al. (2003). "Evidence for a functional interaction between the ClC-2 chloride channel and the retrograde motor dynein complex". J. Biol. Chem. 278 (18): 16262–70. doi:10.1074/jbc.M209828200. PMID 12601004.
- Fan L, Yu W, Zhu X (2003). "Interaction of Sedlin with chloride intracellular channel proteins". FEBS Lett. 540 (1–3): 77–80. doi:10.1016/S0014-5793(03)00228-X. PMID 12681486. S2CID 8573651.
- Board PG, Coggan M, Watson S, et al. (2005). "CLIC-2 modulates cardiac ryanodine receptor Ca2+ release channels". Int. J. Biochem. Cell Biol. 36 (8): 1599–612. doi:10.1016/j.biocel.2004.01.026. PMID 15147738.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
- Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. Bibcode:2005Natur.434..325R. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
- Bruneel A, Labas V, Mailloux A, et al. (2006). "Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis". Proteomics. 5 (15): 3876–84. doi:10.1002/pmic.200401239. PMID 16130169. S2CID 26007149.
- Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
External links
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