CLIC3

Protein-coding gene in the species Homo sapiens

CLIC3

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
3FY7, 3KJY

Identifiers

Aliases

CLIC3, chloride intracellular channel 3

External IDs

OMIM: 606533 MGI: 1916704 HomoloGene: 3432 GeneCards: CLIC3

Gene location (Human)

Chr.	Chromosome 9 (human)^[1]

Band	9q34.3	Start	136,994,608 bp^[1]
Band	9q34.3	End	136,996,568 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 2 (mouse)^[2]

Band	2\|2 A3	Start	25,346,850 bp^[2]
Band	2\|2 A3	End	25,348,788 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

oral cavity

right lobe of thyroid gland

left lobe of thyroid gland

skin of abdomen

right lung

gums

placenta

corpus epididymis

upper lobe of left lung

epithelium of esophagus

Top expressed in

esophagus

right lung lobe

left lung

left lung lobe

corneal stroma

skin of back

skin of abdomen

belly cord

morula

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	protein binding voltage-gated ion channel activity chloride channel activity glutathione transferase activity
Cellular component	cytoplasm integral component of membrane extracellular exosome membrane nucleus chloride channel complex nuclear body
Biological process	regulation of ion transmembrane transport chloride transport ion transport signal transduction chloride transmembrane transport glutathione metabolic process transport ion transmembrane transport
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


9022


69454

Ensembl


ENSG00000169583


ENSMUSG00000015093

UniProt


O95833


Q9D7P7

RefSeq (mRNA)


NM_004669


NM_027085

RefSeq (protein)


NP_004660


NP_081361

Location (UCSC)

Chr 9: 136.99 – 137 Mb

Chr 2: 25.35 – 25.35 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Chloride intracellular channel protein 3 is a protein that in humans is encoded by the CLIC3 gene.^[5] This protein is a chloride channel.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000169583 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000015093 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Qian Z, Okuhara D, Abe MK, Rosner MR (Feb 1999). "Molecular cloning and characterization of a mitogen-activated protein kinase-associated intracellular chloride channel". J Biol Chem. 274 (3): 1621–7. doi:10.1074/jbc.274.3.1621. PMID 9880541.

External links

CLIC3+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Human CLIC3 genome location and CLIC3 gene details page in the UCSC Genome Browser.
Overview of all the structural information available in the PDB for UniProt: O95833 (Human Chloride intracellular channel protein 3 (CLIC3)) at the PDBe-KB.

Membrane transport protein: ion channels (TC 1A)

Ca²⁺: Calcium channel

Ligand-gated	Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3
Voltage-gated	L-type/Ca_vα 1.1 1.2 1.3 1.4 N-type/Ca_vα2.2 P-type/Ca_vα 2.1 Q-type/Ca_vα2.1 R-type/Ca_vα2.3 T-type/Ca_vα 3.1 3.2 3.3 α₂δ-subunits 1 2 β-subunits β1 β2 β3 β4 γ-subunits γ1 γ2 γ3 γ4 Cation channels of sperm 1 2 3 4 Two-pore channel 1 2

Na⁺: Sodium channel

Constitutively active	Epithelial sodium channel α β γ δ
Proton-gated	Amiloride-sensitive cation channel 1 2 3 4
Voltage-gated	Na_vα 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 7A Na_vβ 1 2 3 4

K⁺: Potassium channel

Calcium-activated	BK channel α1 β1 β2 β3 β4 SK channel SK1 SK2 SK3 IK channel IK1 K_Ca 1.1 2.1 2.2 2.3 3.1 4.1 4.2 5.1
Inward-rectifier	K_ATP K_ir 1.1 2.1 2.2 2.3 2.4 2.6 GIRK/K_ir 3.1 3.2 3.3 3.4 K_ir 4.1 4.2 5.1 6.1 6.2 7.1
Tandem pore domain	K2P 1 2 3 4 5 6 7 9 10 12 13 15 16 17 18
Voltage-gated	K_vα1-6 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 2.1 2.2 3.1 3.2 3.3 3.4 4.1 4.2 4.3 5.1 6.1 6.2 6.3 6.4 K_vα7-12 7.1 7.2 7.3 7.4 7.5 8.1 8.2 9.1 9.2 9.3 10.1 10.2 11.1/hERG 11.2 11.3 12.1 12.2 12.3 K_vβ 1 2 3 KCNIP 1 2 3 4 minK/ISK minK/ISK-like MiRP 1 2 3 Shaker (gene)

Miscellaneous

Cl⁻: Chloride channel	Calcium-activated chloride channels Anoctamin ANO1 Bestrophin 1 2 Chloride Channel Accessory 1 2 3 4 CFTR CLCN 1 2 3 4 5 6 7 KA KB CLIC 1 2 3 4 5 6 L1 CLNS 1A 1B
H⁺: Proton channel	HVCN1
M⁺: CNG cation channel	α 1 2 3 4 β 1 2 3 HCN FC 1 2 3 4
M⁺: TRP cation channel	TRPA (1) TRPC 1 2 3 4 4AP 5 6 7 TRPM 1 2 3 4 5 6 7 8 TRPML 1 2 3 TRPN TRPP 1 2 TRPV 1 2 3 4 5 6
H₂O (+ solutes): Porin	Aquaporin 0 1 2 3 4 5 6 7 8 9 Voltage-dependent anion channel 1 2 3 General bacterial porin family
Cytoplasm: Gap junction	Connexin A GJA1 GJA3 GJA4 GJA5 GJA8 GJA9 GJA10 B GJB1 GJB2 GJB3 GJB4 GJB5 GJB6 GJB7 C GJC1 GJC2 GJC3 D GJD2 GJD3 GJD4 Innexin