KCNK5

Protein-coding gene in the species Homo sapiens

KCNK5

Identifiers

Aliases

KCNK5, K2p5.1, TASK-2, TASK2, KCNK5b, potassium two pore domain channel subfamily K member 5

External IDs

OMIM: 603493 MGI: 1336175 HomoloGene: 2773 GeneCards: KCNK5

Gene location (Human)

Chr.	Chromosome 6 (human)^[1]

Band	6p21.2	Start	39,188,971 bp^[1]
Band	6p21.2	End	39,229,475 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 14 (mouse)^[2]

Band	14\|14 A3	Start	20,190,125 bp^[2]
Band	14\|14 A3	End	20,231,877 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

pancreatic ductal cell

oocyte

duodenum

kidney

kidney tubule

secondary oocyte

jejunal mucosa

gallbladder

right lobe of liver

tibia

Top expressed in

proximal tubule

intestinal villus

kidney

left colon

jejunum

pyloric antrum

morula

duodenum

ileum

epithelium of stomach

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	voltage-gated potassium channel activity potassium channel activity voltage-gated ion channel activity potassium ion leak channel activity
Cellular component	integral component of membrane integral component of plasma membrane membrane
Biological process	potassium ion transport regulation of ion transmembrane transport excretion ion transport potassium ion transmembrane transport stabilization of membrane potential
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


8645


16529

Ensembl


ENSG00000164626


ENSMUSG00000023243

UniProt


O95279


Q9JK62

RefSeq (mRNA)


NM_003740


NM_021542

RefSeq (protein)


NP_003731


NP_067517

Location (UCSC)

Chr 6: 39.19 – 39.23 Mb

Chr 14: 20.19 – 20.23 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Potassium channel subfamily K member 5 is a protein that in humans is encoded by the KCNK5 gene.^[5]^[6]^[7]

This gene encodes K_2P5.1, one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The message for this gene is mainly expressed in the cortical distal tubules and collecting ducts of the kidney. The protein is highly sensitive to external pH and this, in combination with its expression pattern, suggests it may play an important role in renal potassium transport.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000164626 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000023243 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Reyes R, Duprat F, Lesage F, Fink M, Salinas M, Farman N, Lazdunski M (Dec 1998). "Cloning and expression of a novel pH-sensitive two pore domain K+ channel from human kidney". J Biol Chem. 273 (47): 30863–9. doi:10.1074/jbc.273.47.30863. PMID 9812978.
^ Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (Dec 2005). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels". Pharmacol Rev. 57 (4): 527–40. doi:10.1124/pr.57.4.12. PMID 16382106. S2CID 7356601.
^ ^a ^b "Entrez Gene: KCNK5 potassium channel, subfamily K, member 5".

External links

KCNK5+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Membrane transport protein: ion channels (TC 1A)

Ca²⁺: Calcium channel

Ligand-gated	Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3
Voltage-gated	L-type/Ca_vα 1.1 1.2 1.3 1.4 N-type/Ca_vα2.2 P-type/Ca_vα 2.1 Q-type/Ca_vα2.1 R-type/Ca_vα2.3 T-type/Ca_vα 3.1 3.2 3.3 α₂δ-subunits 1 2 β-subunits β1 β2 β3 β4 γ-subunits γ1 γ2 γ3 γ4 Cation channels of sperm 1 2 3 4 Two-pore channel 1 2

Na⁺: Sodium channel

Constitutively active	Epithelial sodium channel α β γ δ
Proton-gated	Amiloride-sensitive cation channel 1 2 3 4
Voltage-gated	Na_vα 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 7A Na_vβ 1 2 3 4

K⁺: Potassium channel

Calcium-activated	BK channel α1 β1 β2 β3 β4 SK channel SK1 SK2 SK3 IK channel IK1 K_Ca 1.1 2.1 2.2 2.3 3.1 4.1 4.2 5.1
Inward-rectifier	K_ATP K_ir 1.1 2.1 2.2 2.3 2.4 2.6 GIRK/K_ir 3.1 3.2 3.3 3.4 K_ir 4.1 4.2 5.1 6.1 6.2 7.1
Tandem pore domain	K2P 1 2 3 4 5 6 7 9 10 12 13 15 16 17 18
Voltage-gated	K_vα1-6 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 2.1 2.2 3.1 3.2 3.3 3.4 4.1 4.2 4.3 5.1 6.1 6.2 6.3 6.4 K_vα7-12 7.1 7.2 7.3 7.4 7.5 8.1 8.2 9.1 9.2 9.3 10.1 10.2 11.1/hERG 11.2 11.3 12.1 12.2 12.3 K_vβ 1 2 3 KCNIP 1 2 3 4 minK/ISK minK/ISK-like MiRP 1 2 3 Shaker (gene)

Miscellaneous

Cl⁻: Chloride channel	Calcium-activated chloride channels Anoctamin ANO1 Bestrophin 1 2 Chloride Channel Accessory 1 2 3 4 CFTR CLCN 1 2 3 4 5 6 7 KA KB CLIC 1 2 3 4 5 6 L1 CLNS 1A 1B
H⁺: Proton channel	HVCN1
M⁺: CNG cation channel	α 1 2 3 4 β 1 2 3 HCN FC 1 2 3 4
M⁺: TRP cation channel	TRPA (1) TRPC 1 2 3 4 4AP 5 6 7 TRPM 1 2 3 4 5 6 7 8 TRPML 1 2 3 TRPN TRPP 1 2 TRPV 1 2 3 4 5 6
H₂O (+ solutes): Porin	Aquaporin 0 1 2 3 4 5 6 7 8 9 Voltage-dependent anion channel 1 2 3 General bacterial porin family
Cytoplasm: Gap junction	Connexin A GJA1 GJA3 GJA4 GJA5 GJA8 GJA9 GJA10 B GJB1 GJB2 GJB3 GJB4 GJB5 GJB6 GJB7 C GJC1 GJC2 GJC3 D GJD2 GJD3 GJD4 Innexin