TRPC7

Protein-coding gene in the species Homo sapiens
TRPC7
Identifiers
AliasesTRPC7, TRP7, transient receptor potential cation channel subfamily C member 7
External IDsMGI: 1349470 HomoloGene: 22689 GeneCards: TRPC7
Gene location (Human)
Chromosome 5 (human)
Chr.Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for TRPC7
Genomic location for TRPC7
Band5q31.1Start136,212,745 bp[1]
End136,365,545 bp[1]
Gene location (Mouse)
Chromosome 13 (mouse)
Chr.Chromosome 13 (mouse)[2]
Chromosome 13 (mouse)
Genomic location for TRPC7
Genomic location for TRPC7
Band13|13 B1Start56,920,926 bp[2]
End57,043,806 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • secondary oocyte

  • kidney

  • rectum

  • duodenum

  • anterior pituitary

  • hypothalamus

  • gallbladder

  • putamen

  • nucleus accumbens

  • islet of Langerhans
Top expressed in
  • ventromedial nucleus

  • intestinal villus

  • paraventricular nucleus of hypothalamus

  • globus pallidus

  • olfactory tubercle

  • lateral hypothalamus

  • medial dorsal nucleus

  • subiculum

  • inferior colliculus

  • piriform cortex
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • store-operated calcium channel activity
  • ion channel activity
  • protein binding
  • calcium channel activity
  • inositol 1,4,5 trisphosphate binding
Cellular component
  • integral component of membrane
  • nuclear envelope
  • membrane
  • cis-Golgi network
  • plasma membrane
  • integral component of plasma membrane
  • perinuclear region of cytoplasm
  • nucleus
  • cation channel complex
Biological process
  • regulation of cytosolic calcium ion concentration
  • ion transport
  • single fertilization
  • platelet activation
  • calcium ion transmembrane transport
  • manganese ion transport
  • calcium ion transport
  • transmembrane transport
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

57113

26946

Ensembl

ENSG00000069018

ENSMUSG00000021541

UniProt

Q9HCX4

Q9WVC5

RefSeq (mRNA)

NM_001167576
NM_001167577
NM_020389
NM_001376901

NM_012035
NM_001302372
NM_001302373

RefSeq (protein)

NP_001161048
NP_001161049
NP_065122
NP_001363830

NP_001289301
NP_001289302
NP_036165

Location (UCSC)Chr 5: 136.21 – 136.37 MbChr 13: 56.92 – 57.04 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Transient receptor potential cation channel, subfamily C, member 7, also known as TRPC7, is a human gene encoding a protein of the same name.

See also

Further reading

  • Islam, Md. Shahidul (January 2011). Transient Receptor Potential Channels. Advances in Experimental Medicine and Biology. Vol. 704. Berlin: Springer. p. 700. ISBN 978-94-007-0264-6.
  • Clapham DE, Julius D, Montell C, Schultz G (2006). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels". Pharmacol. Rev. 57 (4): 427–50. doi:10.1124/pr.57.4.6. PMID 16382100. S2CID 17936350.
  • Numaga T, Wakamori M, Mori Y (2007). "TRPC7". Transient Receptor Potential (TRP) Channels. Handbook of Experimental Pharmacology. Vol. 179. pp. 143–51. doi:10.1007/978-3-540-34891-7_8. ISBN 978-3-540-34889-4. PMID 17217055.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

  • v
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  • e
Ligand-gated
Voltage-gated
Constitutively active
Proton-gated
Voltage-gated
Calcium-activated
Inward-rectifier
Tandem pore domain
Voltage-gated
Miscellaneous
Cl: Chloride channel
H+: Proton channel
M+: CNG cation channel
M+: TRP cation channel
H2O (+ solutes): Porin
Cytoplasm: Gap junction
By gating mechanism
Ion channel class
see also disorders
  • v
  • t
  • e
TRP channel modulators
TRPA
Activators
Blockers
TRPC
Activators
Blockers
TRPM
Activators
Blockers
TRPML
Activators
Blockers
TRPP
Activators
Blockers
TRPV
Activators
Blockers
See also: Receptor/signaling modulators • Ion channel modulators
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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000069018 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021541 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.