KCNA6

Protein-coding gene in humans

KCNA6

Identifiers

Aliases

KCNA6, HBK2, KV1.6, PPP1R96, potassium voltage-gated channel subfamily A member 6

External IDs

OMIM: 176257 MGI: 96663 HomoloGene: 1684 GeneCards: KCNA6

Gene location (Human)

Chr.	Chromosome 12 (human)^[1]

Band	12p13.32	Start	4,809,334 bp^[1]
Band	12p13.32	End	4,813,318 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 6 (mouse)^[2]

Band	6 F3\|6 61.72 cM	Start	126,685,292 bp^[2]
Band	6 F3\|6 61.72 cM	End	126,717,637 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

prefrontal cortex

islet of Langerhans

Brodmann area 9

Achilles tendon

cingulate gyrus

ganglionic eminence

hypothalamus

caudate nucleus

superior frontal gyrus

Brodmann area 46

Top expressed in

medial dorsal nucleus

superior frontal gyrus

lateral hypothalamus

globus pallidus

medial vestibular nucleus

trigeminal ganglion

cerebellar cortex

lateral geniculate nucleus

medial geniculate nucleus

ventral tegmental area

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	voltage-gated potassium channel activity ion channel activity potassium channel activity delayed rectifier potassium channel activity voltage-gated ion channel activity
Cellular component	axon terminus integral component of membrane voltage-gated potassium channel complex axon plasma membrane potassium channel complex integral component of plasma membrane membrane
Biological process	potassium ion transport regulation of ion transmembrane transport protein homooligomerization ion transport transmembrane transport potassium ion transmembrane transport
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


3742


16494

Ensembl


ENSG00000151079


ENSMUSG00000038077

UniProt


P17658


Q61923

RefSeq (mRNA)


NM_002235


NM_013568

RefSeq (protein)


NP_002226


NP_038596

Location (UCSC)

Chr 12: 4.81 – 4.81 Mb

Chr 6: 126.69 – 126.72 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Potassium voltage-gated channel subfamily A member 6 also known as K_v1.6 is a protein that in humans is encoded by the KCNA6 gene.^[5] The protein encoded by this gene is a voltage-gated potassium channel subunit.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000151079 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000038077 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X (Dec 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels" (PDF). Pharmacol Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104. S2CID 219195192.

External links

Kv1.6+Potassium+Channel at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
KCNA6+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

Membrane transport protein: ion channels (TC 1A)

Ca²⁺: Calcium channel

Ligand-gated	Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3
Voltage-gated	L-type/Ca_vα 1.1 1.2 1.3 1.4 N-type/Ca_vα2.2 P-type/Ca_vα 2.1 Q-type/Ca_vα2.1 R-type/Ca_vα2.3 T-type/Ca_vα 3.1 3.2 3.3 α₂δ-subunits 1 2 β-subunits β1 β2 β3 β4 γ-subunits γ1 γ2 γ3 γ4 Cation channels of sperm 1 2 3 4 Two-pore channel 1 2

Na⁺: Sodium channel

Constitutively active	Epithelial sodium channel α β γ δ
Proton-gated	Amiloride-sensitive cation channel 1 2 3 4
Voltage-gated	Na_vα 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 7A Na_vβ 1 2 3 4

K⁺: Potassium channel

Calcium-activated	BK channel α1 β1 β2 β3 β4 SK channel SK1 SK2 SK3 IK channel IK1 K_Ca 1.1 2.1 2.2 2.3 3.1 4.1 4.2 5.1
Inward-rectifier	K_ATP K_ir 1.1 2.1 2.2 2.3 2.4 2.6 GIRK/K_ir 3.1 3.2 3.3 3.4 K_ir 4.1 4.2 5.1 6.1 6.2 7.1
Tandem pore domain	K2P 1 2 3 4 5 6 7 9 10 12 13 15 16 17 18
Voltage-gated	K_vα1-6 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 2.1 2.2 3.1 3.2 3.3 3.4 4.1 4.2 4.3 5.1 6.1 6.2 6.3 6.4 K_vα7-12 7.1 7.2 7.3 7.4 7.5 8.1 8.2 9.1 9.2 9.3 10.1 10.2 11.1/hERG 11.2 11.3 12.1 12.2 12.3 K_vβ 1 2 3 KCNIP 1 2 3 4 minK/ISK minK/ISK-like MiRP 1 2 3 Shaker (gene)

Miscellaneous

Cl⁻: Chloride channel	Calcium-activated chloride channels Anoctamin ANO1 Bestrophin 1 2 Chloride Channel Accessory 1 2 3 4 CFTR CLCN 1 2 3 4 5 6 7 KA KB CLIC 1 2 3 4 5 6 L1 CLNS 1A 1B
H⁺: Proton channel	HVCN1
M⁺: CNG cation channel	α 1 2 3 4 β 1 2 3 HCN FC 1 2 3 4
M⁺: TRP cation channel	TRPA (1) TRPC 1 2 3 4 4AP 5 6 7 TRPM 1 2 3 4 5 6 7 8 TRPML 1 2 3 TRPN TRPP 1 2 TRPV 1 2 3 4 5 6
H₂O (+ solutes): Porin	Aquaporin 0 1 2 3 4 5 6 7 8 9 Voltage-dependent anion channel 1 2 3 General bacterial porin family
Cytoplasm: Gap junction	Connexin A GJA1 GJA3 GJA4 GJA5 GJA8 GJA9 GJA10 B GJB1 GJB2 GJB3 GJB4 GJB5 GJB6 GJB7 C GJC1 GJC2 GJC3 D GJD2 GJD3 GJD4 Innexin