TRPC1

TRPC1
Identifiers
Aliases	TRPC1, HTRP-1, TRP1, transient receptor potential cation channel subfamily C member 1
External IDs	OMIM: 602343 MGI: 109528 HomoloGene: 2478 GeneCards: TRPC1
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q23 Start 142,724,034 bp[1] End 142,807,888 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 E3.3|9 50.2 cM Start 95,587,135 bp[2] End 95,632,428 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in germinal epithelium Achilles tendon tibia Brodmann area 23 endothelial cell middle temporal gyrus parietal pleura corpus callosum cerebellar vermis saphenous vein Top expressed in retinal pigment epithelium barrel cortex olfactory tubercle medial dorsal nucleus subiculum cerebellar vermis nucleus accumbens ciliary body spermatocyte facial motor nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function store-operated calcium channel activity transmembrane transporter binding calcium channel activity inositol 1,4,5 trisphosphate binding ion channel activity protein binding cation channel activity Cellular component integral component of membrane membrane receptor complex plasma membrane integral component of plasma membrane cation channel complex Biological process melanin biosynthetic process regulation of cardiac conduction regulation of cytosolic calcium ion concentration positive regulation of release of sequestered calcium ion into cytosol ion transport response to calcium ion calcium ion transmembrane transport manganese ion transport calcium ion transport transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7220 22063 Ensembl ENSG00000144935 ENSMUSG00000032839 UniProt P48995 Q61056 RefSeq (mRNA) NM_001251845 NM_003304 NM_011643 NM_001311123 RefSeq (protein) NP_001238774 NP_003295 NP_001298052 NP_035773 Location (UCSC) Chr 3: 142.72 – 142.81 Mb Chr 9: 95.59 – 95.63 Mb PubMed search [3] [4]
Wikidata
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Transient receptor potential canonical 1 (TRPC1) is a protein that in humans is encoded by the TRPC1 gene.^[5][6]

Function

TRPC1 is an ion channel located on the plasma membrane of numerous human and animal cell types. ^[7] It is a nonspecific cation channel, which means that both sodium and calcium ions can pass through it. TRPC1 is thought to mediate calcium entry in response to depletion of endoplasmic calcium stores or activation of receptors coupled to the phospholipase C system. In HEK293 cells the unitary current-voltage relationship of endogenous TRPC1 channels is almost linear, with a slope conductance of about 17 pS. The extrapolated reversal potential of TRPC1 channels is +30 mV.^[8] The TRPC1 protein is widely expressed throughout the mammalian brain and has a similar corticolimbic expression pattern as TRPC4 and TRPC5. ^[9][10] The highest density of TRPC1 protein is found in the lateral septum, an area with dense TRPC4 expression, and hippocampus and prefrontal cortex, areas with dense TRPC5 expression.^[10]

History

TRPC1 was the first mammalian Transient Receptor Potential channel to be identified. In 1995 it was cloned when the research groups headed by Craig Montell and Lutz Birnbaumer were searching for proteins similar to the TRP channel in Drosophila. Together with TRPC3 they became the founding members of the TRPC ion channel family.^[5][6]

Interactions

TRPC1 has been shown to interact with:

• HOMER3,^[11]
• Polycystic kidney disease 2,^[12]
• RHOA^[13]
• TRPC3,^[14][15]
• TRPC4,^[14][16] and
• TRPC5.^[14][16]

See also

• TRPC

References

Further reading

External links

• TRPC1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• "TRIP Database". a manually curated database of protein-protein interactions for mammalian TRP channels.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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