TRPC4AP

Protein-coding gene in the species Homo sapiens
TRPC4AP
Identifiers
AliasesTRPC4AP, C20orf188, PPP1R158, TRRP4AP, TRUSS, transient receptor potential cation channel subfamily C member 4 associated protein
External IDsOMIM: 608430 MGI: 1930751 HomoloGene: 9224 GeneCards: TRPC4AP
Gene location (Human)
Chromosome 20 (human)
Chr.Chromosome 20 (human)[1]
Chromosome 20 (human)
Genomic location for TRPC4AP
Genomic location for TRPC4AP
Band20q11.22Start35,002,404 bp[1]
End35,092,807 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for TRPC4AP
Genomic location for TRPC4AP
Band2 H1|2 77.26 cMStart155,476,191 bp[2]
End155,534,304 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • anterior pituitary

  • gastric mucosa

  • body of pancreas

  • left adrenal gland

  • stromal cell of endometrium

  • gastrocnemius muscle

  • upper lobe of left lung

  • right lung

  • body of stomach

  • right lobe of thyroid gland
Top expressed in
  • spermatocyte

  • entorhinal cortex

  • thymus

  • cerebellar cortex

  • superior frontal gyrus

  • superior colliculus

  • secondary oocyte

  • ankle

  • pontine nuclei

  • medulla oblongata
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • phosphatase binding
  • protein binding
  • calcium channel activity
Cellular component
  • plasma membrane
  • Cul4A-RING E3 ubiquitin ligase complex
Biological process
  • calcium ion transmembrane transport
  • protein ubiquitination
  • hair follicle maturation
  • ubiquitin-dependent protein catabolic process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

26133

56407

Ensembl

ENSG00000100991

ENSMUSG00000038324

UniProt

Q8TEL6

Q9JLV2

RefSeq (mRNA)

NM_015638
NM_199368

NM_001163452
NM_019828

RefSeq (protein)

NP_056453
NP_955400

NP_001156924
NP_062802

Location (UCSC)Chr 20: 35 – 35.09 MbChr 2: 155.48 – 155.53 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Trpc4-associated protein is a protein that in humans is encoded by the TRPC4AP gene.

Interactions

TRPC4AP has been shown to interact with TNFRSF1A.[5][clarification needed]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000100991 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038324 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Soond SM, Terry JL, Colbert JD, Riches DW (Nov 2003). "TRUSS, a novel tumor necrosis factor receptor 1 scaffolding protein that mediates activation of the transcription factor NF-kappaB". Mol. Cell. Biol. 23 (22): 8334–44. doi:10.1128/MCB.23.22.8334-8344.2003. PMC 262424. PMID 14585990.
  • v
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Ligand-gated
Voltage-gated
Constitutively active
Proton-gated
Voltage-gated
Calcium-activated
Inward-rectifier
Tandem pore domain
Voltage-gated
Miscellaneous
Cl: Chloride channel
H+: Proton channel
M+: CNG cation channel
M+: TRP cation channel
H2O (+ solutes): Porin
Cytoplasm: Gap junction
By gating mechanism
Ion channel class
see also disorders
  • v
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  • e
TRP channel modulators
TRPA
Activators
Blockers
TRPC
Activators
Blockers
TRPM
Activators
Blockers
TRPML
Activators
Blockers
TRPP
Activators
Blockers
TRPV
Activators
Blockers
See also: Receptor/signaling modulators • Ion channel modulators


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