GPR135

Protein-coding gene in the species Homo sapiens
GPR135
Identifiers
AliasesGPR135, HUMNPIIY20, G protein-coupled receptor 135
External IDsOMIM: 607970 MGI: 2676315 HomoloGene: 11211 GeneCards: GPR135
Gene location (Human)
Chromosome 14 (human)
Chr.Chromosome 14 (human)[1]
Chromosome 14 (human)
Genomic location for GPR135
Genomic location for GPR135
Band14q23.1Start59,429,022 bp[1]
End59,465,380 bp[1]
Gene location (Mouse)
Chromosome 12 (mouse)
Chr.Chromosome 12 (mouse)[2]
Chromosome 12 (mouse)
Genomic location for GPR135
Genomic location for GPR135
Band12|12 C3Start72,114,750 bp[2]
End72,117,899 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • sperm

  • right uterine tube

  • right coronary artery

  • left coronary artery

  • popliteal artery

  • stromal cell of endometrium

  • ascending aorta

  • anterior pituitary

  • bronchial epithelial cell

  • ganglionic eminence
Top expressed in
  • substantia nigra

  • Region I of hippocampus proper

  • ventromedial nucleus

  • paraventricular nucleus of hypothalamus

  • dorsomedial hypothalamic nucleus

  • arcuate nucleus

  • lateral hypothalamus

  • fossa

  • subiculum

  • cingulate gyrus
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
  • G protein-coupled receptor activity
  • signal transducer activity
  • protein binding
  • arrestin family protein binding
Cellular component
  • integral component of membrane
  • membrane
  • plasma membrane
  • endosome
  • endosome membrane
Biological process
  • G protein-coupled receptor signaling pathway
  • signal transduction
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

64582

238252

Ensembl

ENSG00000181619

ENSMUSG00000043398

UniProt

Q8IZ08

Q7TQP2

RefSeq (mRNA)

NM_022571

NM_181752

RefSeq (protein)

NP_072093

NP_861417

Location (UCSC)Chr 14: 59.43 – 59.47 MbChr 12: 72.11 – 72.12 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Probable G-protein coupled receptor 135 is a protein that in humans is encoded by the GPR135 gene.[5][6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000181619 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000043398 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Fredriksson R, Hoglund PJ, Gloriam DE, Lagerstrom MC, Schioth HB (Nov 2003). "Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives". FEBS Lett. 554 (3): 381–8. doi:10.1016/S0014-5793(03)01196-7. PMID 14623098. S2CID 11563502.
  6. ^ "Entrez Gene: GPR135 G protein-coupled receptor 135".

Further reading

  • Kunz D, Gerard NP, Gerard C (1992). "The human leukocyte platelet-activating factor receptor. cDNA cloning, cell surface expression, and construction of a novel epitope-bearing analog". J. Biol. Chem. 267 (13): 9101–6. doi:10.1016/S0021-9258(19)50394-5. PMID 1374385.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Vassilatis DK, Hohmann JG, Zeng H, et al. (2003). "The G protein-coupled receptor repertoires of human and mouse". Proc. Natl. Acad. Sci. U.S.A. 100 (8): 4903–8. Bibcode:2003PNAS..100.4903V. doi:10.1073/pnas.0230374100. PMC 153653. PMID 12679517.
  • Vanti WB, Nguyen T, Cheng R, et al. (2003). "Novel human G-protein-coupled receptors". Biochem. Biophys. Res. Commun. 305 (1): 67–71. doi:10.1016/S0006-291X(03)00709-5. PMID 12732197.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
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