GPR68

Protein-coding gene in the species Homo sapiens

GPR68

Identifiers

Aliases

GPR68, GPR12A, OGR1, G protein-coupled receptor 68, AI2A6

External IDs

OMIM: 601404 MGI: 2441763 HomoloGene: 2603 GeneCards: GPR68

Gene location (Human)

Chr.	Chromosome 14 (human)^[1]

Band	14q32.11	Start	91,232,532 bp^[1]
Band	14q32.11	End	91,253,925 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 12 (mouse)^[2]

Band	12\|12 E	Start	100,842,941 bp^[2]
Band	12\|12 E	End	100,874,457 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

cardia

pylorus

saphenous vein

pituitary gland

human penis

amniotic fluid

superior surface of tongue

anterior pituitary

nipple

blood

Top expressed in

oocyte

secondary oocyte

cerebellar cortex

hippocampus proper

ciliary body

facial motor nucleus

blood

superior frontal gyrus

thymus

anterior horn of spinal cord

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	G protein-coupled receptor activity signal transducer activity
Cellular component	integral component of membrane plasma membrane integral component of plasma membrane membrane
Biological process	G protein-coupled receptor signaling pathway negative regulation of monocyte differentiation positive regulation of insulin secretion involved in cellular response to glucose stimulus cellular response to pH inflammatory response positive regulation of osteoclast development signal transduction positive regulation of insulin secretion
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


8111


238377

Ensembl


ENSG00000119714


ENSMUSG00000047415

UniProt


Q15743


Q8BFQ3

RefSeq (mRNA)


NM_001177676 NM_003485 NM_001348437


NM_001177673 NM_001177674 NM_175493

RefSeq (protein)


NP_001171147 NP_003476 NP_001335366


NP_001171144 NP_001171145 NP_780702 NP_001390243

Location (UCSC)

Chr 14: 91.23 – 91.25 Mb

Chr 12: 100.84 – 100.87 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Ovarian cancer G-protein coupled receptor 1 is a protein that in humans is encoded by the GPR68 gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000119714 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000047415 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Xu Y, Casey G (Sep 1996). "Identification of human OGR1, a novel G protein-coupled receptor that maps to chromosome 14". Genomics. 35 (2): 397–402. doi:10.1006/geno.1996.0377. PMID 8661159.
^ "Entrez Gene: GPR68 G protein-coupled receptor 68".

Xu Y (2002). "Sphingosylphosphorylcholine and lysophosphatidylcholine: G protein-coupled receptors and receptor-mediated signal transduction". Biochim. Biophys. Acta. 1582 (1–3): 81–8. doi:10.1016/S1388-1981(02)00140-3. PMID 12069813.
An S, Tsai C, Goetzl EJ (1996). "Cloning, sequencing and tissue distribution of two related G protein-coupled receptor candidates expressed prominently in human lung tissue". FEBS Lett. 375 (1–2): 121–4. doi:10.1016/0014-5793(95)01196-L. PMID 7498459. S2CID 9845527.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ludwig MG, Vanek M, Guerini D, et al. (2003). "Proton-sensing G-protein-coupled receptors". Nature. 425 (6953): 93–8. Bibcode:2003Natur.425...93L. doi:10.1038/nature01905. PMID 12955148. S2CID 4395698.
Bektas M, Barak LS, Jolly PS, et al. (2003). "The G protein-coupled receptor GPR4 suppresses ERK activation in a ligand-independent manner". Biochemistry. 42 (42): 12181–91. doi:10.1021/bi035051y. PMID 14567679.
Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Radu CG, Nijagal A, McLaughlin J, et al. (2005). "Differential proton sensitivity of related G protein-coupled receptors T cell death-associated gene 8 and G2A expressed in immune cells". Proc. Natl. Acad. Sci. U.S.A. 102 (5): 1632–7. Bibcode:2005PNAS..102.1632R. doi:10.1073/pnas.0409415102. PMC 545089. PMID 15665078.
Tomura H, Wang JQ, Komachi M, et al. (2005). "Prostaglandin I(2) production and cAMP accumulation in response to acidic extracellular pH through OGR1 in human aortic smooth muscle cells". J. Biol. Chem. 280 (41): 34458–64. doi:10.1074/jbc.M505287200. PMID 16087674.
Singh LS, Berk M, Oates R, et al. (2007). "Ovarian cancer G protein-coupled receptor 1, a new metastasis suppressor gene in prostate cancer". J. Natl. Cancer Inst. 99 (17): 1313–27. doi:10.1093/jnci/djm107. hdl:10536/DRO/DU:30094039. PMID 17728215.

Cell surface receptor: G protein-coupled receptors

Class A: Rhodopsin-like

Neurotransmitter

Adrenergic	α1 (A B D) α2 (A B C) β1 β2 β3
Purinergic	Adenosine (A1 A2A A2B A3) P2Y (1 2 4 5 6 8 9 10 11 12 13 14)
Serotonin	(all but 5-HT3) 5-HT1 (A B D E F) 5-HT2 (A B C) 5-HT (4 5A 6 7)
Other	Acetylcholine (M1 M2 M3 M4 M5) Dopamine D1 D2 D3 D4 D5 GHB receptor Histamine H1 H2 H3 H4 Melatonin (1A 1B 1C) TAAR (1 2 5 6 8 9)

Metabolites and
signaling molecules

Eicosanoid	CysLT (1 2) LTB4 1 2 FPRL1 OXE Prostaglandin DP (1 2), EP (1 2 3 4), FP Prostacyclin Thromboxane
Other	Bile acid Cannabinoid (CB1 CB2, GPR (18 55 119)) EBI2 Estrogen Free fatty acid (1 2 3 4) Hydroxycarboxylic acids 1 2 3 Lysophosphatidic acid (1 2 3 4 5 6) Lysophospholipid (1 2 3 4 5 6 7 8) Oxoglutarate PAF Sphingosine-1-phosphate (1 2 3 4 5) Succinate

Peptide

Neuropeptide

B/W (1
2)
FF (1
2)
S
Y (1
2
4
5)
Neuromedin (B
U (1
2))
Neurotensin (1
2)

Other

Anaphylatoxin (C3a
C5a (1
2))
Angiotensin (1
2)
Apelin
Bombesin
- BRS3
- GRPR
- NMBR)
- Bradykinin (B1
- B2)
Chemokine
Cholecystokinin (A
B)
Endothelin
- A
- B
Formyl peptide (1
2
3)
FSH
Galanin (1
2
3)
Gonadotropin-releasing hormone (1
2)
Ghrelin
Kisspeptin
Luteinizing hormone/choriogonadotropin
MAS (1
1L
D
E
F
G
X1
X2
X3
X4)
Melanocortin (1
2
3
4
5)
MCHR (1
2)
Motilin
Opioid (Delta
Kappa
Mu
Nociceptin & Zeta, but not Sigma)
Orexin (1
2)
Oxytocin
Prokineticin (1
2)
Prolactin-releasing peptide
Relaxin (1
2
3
4)
Somatostatin (1
2
3
4
5)
Tachykinin (1
2
3)
Thyrotropin
Thyrotropin-releasing hormone
Urotensin-II
Vasopressin (1A
1B
2)

Miscellaneous

Taste, bitter	TAS2R 1 3 4 5 7 8 9 10 13 14 16 19 20 30 31 38 39 40 41 42 43 45 46 50 60 Vomeronasal receptor type 1
Orphan	GPR (1 3 4 6 12 15 17 18 19 20 21 22 23 25 26 27 31 32 33 34 35 37 39 42 44 45 50 52 55 61 62 63 65 68 75 78 81 82 83 84 85 87 88 92 101 103 109A 109B 119 120 132 135 137B 139 141 142 146 148 149 150 151 152 153 160 161 162 171 173 174 176 177 182 183)
Other	Adrenomedullin Olfactory Opsin (3 4 5 1LW 1MW 1SW RGR RRH) Protease-activated (1 2 3 4) SREB (1 2 3)

Class B: Secretin-like

Adhesion	ADGRB Brain-specific angiogenesis inhibitor 1 2 3 ADGRC Cadherin 1 2 3 ADGRE EMR 1 2 3 CD97 ADGRG 1 2 3 4 5 6 7 ADGRL Latrophilin 1 2 3 ELTD1
Orphan	GPR (56 64 97 98 110 111 112 113 114 115 116 123 124 125 126 128 133 143 144 155 157)
Other	Calcitonin CALCRL Corticotropin-releasing hormone (1 2) Glucagon (GR GIPR GLP1R GLP2R) Growth-hormone-releasing hormone PACAPR1 GPR Methuselah-like proteins Parathyroid hormone (1 2) Secretin Vasoactive intestinal peptide (1 2)

Class C: Metabotropic glutamate / pheromone

Taste, sweet	TAS1R 1 2 3 Vomeronasal receptor, type 2
Other	Calcium-sensing receptor GABA_B (1 2) Glutamate receptor (Metabotropic glutamate (1 2 3 4 5 6 7 8)) GPRC6A GPR (156 158 179) RAIG (1 2 3 4)