Protein-coding gene in the species Homo sapiens
| GPR158 |
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| Identifiers |
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| Aliases | GPR158, G protein-coupled receptor 158 |
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| External IDs | OMIM: 614573 MGI: 2441697 HomoloGene: 19381 GeneCards: GPR158 |
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| Gene location (Human) |
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 | | Chr. | Chromosome 10 (human)[1] |
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| | Band | 10p12.1 | Start | 25,174,802 bp[1] |
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| End | 25,602,229 bp[1] |
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| Gene location (Mouse) |
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 | | Chr. | Chromosome 2 (mouse)[2] |
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| | Band | 2|2 A3 | Start | 21,372,353 bp[2] |
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| End | 21,835,358 bp[2] |
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| RNA expression pattern |
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| Bgee | | Human | Mouse (ortholog) |
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| Top expressed in | - endothelial cell
- middle temporal gyrus
- cerebellar vermis
- Brodmann area 23
- Brodmann area 46
- pons
- superior frontal gyrus
- postcentral gyrus
- cerebellar hemisphere
- entorhinal cortex
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| | Top expressed in | - superior frontal gyrus
- cerebellar cortex
- secondary oocyte
- supraoptic nucleus
- hippocampus proper
- cerebellar vermis
- olfactory tubercle
- olfactory bulb
- medial dorsal nucleus
- primary motor cortex
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| | More reference expression data |
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| BioGPS |  | | More reference expression data |
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| Gene ontology |
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| Molecular function | - G protein-coupled receptor activity
- signal transducer activity
| | Cellular component | - integral component of membrane
- plasma membrane
- membrane
| | Biological process | - G protein-coupled receptor signaling pathway
- protein localization to plasma membrane
- signal transduction
| | Sources:Amigo / QuickGO |
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| Orthologs |
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| Species | Human | Mouse |
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| Entrez | | |
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| Ensembl | | |
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| UniProt | | |
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| RefSeq (mRNA) | | |
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| RefSeq (protein) | | |
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| Location (UCSC) | Chr 10: 25.17 – 25.6 Mb | Chr 2: 21.37 – 21.84 Mb |
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| PubMed search | [3] | [4] |
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| Wikidata |
| View/Edit Human | View/Edit Mouse |
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Probable G-protein coupled receptor 158 (GPR158), also known as the metabotropic glycine receptor (mGlyR),[5] is a protein that in humans is encoded by the GPR158 gene.[6]
Function
This protein is an orphan class C GPCR. It is highly expressed in the brain, where it binds to RGS7, an inhibitor of Gi/o-coupled GPCR signaling, localizing it to the plasma membrane.[7]
It is expressed at lower levels in other organs and shows an unusual subcellular localization pattern, being found at both the plasma membrane and in the nucleus.[8]
Clinical significance
Role in mood regulation
GPR158 in the medial prefrontal cortex (mPFC) has been shown to regulate stress-induced depression in a mouse model of depression and has been found to be upregulated in post-mortem tissue samples from humans with major depressive disorder (MDD).[9]
Role in prostate cancer
The GPR158 gene is an androgen-regulated gene that stimulates cell proliferation in prostate cancer cell lines, and it is linked to neuroendocrine differentiation.[10]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000151025 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000045967 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Laboute T, Zucca S, Holcomb M, Patil DN, Garza C, Wheatley BA, Roy RN, Forli S, Martemyanov KA (March 2023). "Orphan receptor GPR158 serves as a metabotropic glycine receptor: mGlyR". Science. 379 (6639): 1352–1358. Bibcode:2023Sci...379.1352L. doi:10.1126/science.add7150. PMC 10751545. PMID 36996198. S2CID 257836784.
- ^ "Entrez Gene: GPR158 G protein-coupled receptor 158".
- ^ Orlandi C, Posokhova E, Masuho I, Ray TA, Hasan N, Gregg RG, Martemyanov KA (2012). "GPR158/179 regulate G protein signaling by controlling localization and activity of the RGS7 complexes". J. Cell Biol. 197 (6): 711–9. doi:10.1083/jcb.201202123. PMC 3373406. PMID 22689652.
- ^ Patel N, Itakura T, Gonzalez JM, Schwartz SG, Fini ME (2013). "GPR158, an orphan member of G protein-coupled receptor Family C: glucocorticoid-stimulated expression and novel nuclear role". PLOS ONE. 8 (2): e57843. Bibcode:2013PLoSO...857843P. doi:10.1371/journal.pone.0057843. PMC 3581496. PMID 23451275.
- ^ Sutton L, Orlandi C, Song C, Oh WC, Muntean BS, Xie K, Filippini A, Xie X, Satterfield R, Yaeger JD, Renner KJ, Young Jr SM, Xu B, Kwon H, Martemyanov KA (2018). "Orphan receptor GPR158 controls stress-induced depression". eLife. 7. doi:10.7554/eLife.33273.001. PMC 5823542. PMID 29419376.
- ^ Patel N, Itakura T, Jeong S, Liao CP, Roy-Burman P, Zandi E, Groshen S, Pinski J, Coetzee GA, Gross ME, Fini ME (2015). "Expression and functional role of orphan receptor GPR158 in prostate cancer growth and progression". PLOS ONE. 10 (2): e0117758. Bibcode:2015PLoSO..1017758P. doi:10.1371/journal.pone.0117758. PMC 4333349. PMID 25693195.
