S1PR5

Protein-coding gene in the species Homo sapiens
S1PR5
Identifiers
AliasesS1PR5, EDG8, Edg-8, S1P5, SPPR-1, SPPR-2, sphingosine-1-phosphate receptor 5
External IDsOMIM: 605146 MGI: 2150641 HomoloGene: 11031 GeneCards: S1PR5
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for S1PR5
Genomic location for S1PR5
Band19p13.2Start10,512,742 bp[1]
End10,517,931 bp[1]
Gene location (Mouse)
Chromosome 9 (mouse)
Chr.Chromosome 9 (mouse)[2]
Chromosome 9 (mouse)
Genomic location for S1PR5
Genomic location for S1PR5
Band9|9 A3Start21,154,208 bp[2]
End21,159,739 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • internal globus pallidus

  • inferior ganglion of vagus nerve

  • corpus callosum

  • substantia nigra

  • subthalamic nucleus

  • blood

  • putamen

  • hippocampus proper

  • amygdala

  • ventral tegmental area
Top expressed in
  • substantia nigra

  • motor neuron

  • conjunctival fornix

  • lateral geniculate nucleus

  • anterior horn of spinal cord

  • cornea

  • pontine nuclei

  • globus pallidus

  • ventral tegmental area

  • lip
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • sphingosine-1-phosphate receptor activity
  • G protein-coupled receptor activity
  • signal transducer activity
Cellular component
  • integral component of membrane
  • plasma membrane
  • membrane
Biological process
  • regulation of neuron differentiation
  • sphingosine-1-phosphate receptor signaling pathway
  • signal transduction
  • G protein-coupled receptor signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

53637

94226

Ensembl

ENSG00000180739

ENSMUSG00000045087

UniProt

Q9H228

Q91X56

RefSeq (mRNA)

NM_030760
NM_001166215

NM_053190

RefSeq (protein)

NP_001159687
NP_110387

NP_444420

Location (UCSC)Chr 19: 10.51 – 10.52 MbChr 9: 21.15 – 21.16 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Sphingosine-1-phosphate receptor 5 also known as S1PR5 is a human gene which encodes a G protein-coupled receptor which binds the lipid signaling molecule sphingosine 1-phosphate (S1P). Hence this receptor is also known as S1P5.[5]

Agonists

  • A-971432[6]
  • Sphingosine 1-phosphate receptor agonists: a patent review (2010-2012)[7]

Evolution

Paralogues for S1PR5 Gene [8]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000180739 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000045087 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: S1PR5 Sphingosine-1-phosphate receptor 5".
  6. ^ Hobson AD, Harris CM, van der Kam EL, Turner SC, Abibi A, Aguirre AL, Bousquet P, Kebede T, Konopacki DB, Gintant G, Kim Y, Larson K, Maull JW, Moore NS, Shi D, Shrestha A, Tang X, Zhang P, Sarris KK (Nov 2015). "Discovery of A-971432, An Orally Bioavailable Selective Sphingosine-1-Phosphate Receptor 5 (S1P5) Agonist for the Potential Treatment of Neurodegenerative Disorders". Journal of Medicinal Chemistry. 58 (23): 9154–70. doi:10.1021/acs.jmedchem.5b00928. PMID 26509640.
  7. ^ Roberts E, Guerrero M, Urbano M, Rosen H (Jul 2013). "Sphingosine 1-phosphate receptor agonists: a patent review (2010-2012)". Expert Opin Ther Pat. 23 (7): 817–41. doi:10.1517/13543776.2013.783022. PMID 23541049. S2CID 24421259.
  8. ^ "GeneCards®: The Human Gene Database".

Further reading

  • Im DS, Heise CE, Ancellin N, O'Dowd BF, Shei GJ, Heavens RP, Rigby MR, Hla T, Mandala S, McAllister G, George SR, Lynch KR (May 2000). "Characterization of a novel sphingosine 1-phosphate receptor, Edg-8". The Journal of Biological Chemistry. 275 (19): 14281–6. doi:10.1074/jbc.275.19.14281. PMID 10799507.
  • Malek RL, Toman RE, Edsall LC, Wong S, Chiu J, Letterle CA, Van Brocklyn JR, Milstien S, Spiegel S, Lee NH (Feb 2001). "Nrg-1 belongs to the endothelial differentiation gene family of G protein-coupled sphingosine-1-phosphate receptors". The Journal of Biological Chemistry. 276 (8): 5692–9. doi:10.1074/jbc.M003964200. PMID 11069896.
  • Hla T (Apr 2001). "Sphingosine 1-phosphate receptors". Prostaglandins. 64 (1–4): 135–142. doi:10.1016/s0090-6980(01)00109-5. PMID 11331101.
  • Im DS, Clemens J, Macdonald TL, Lynch KR (Nov 2001). "Characterization of the human and mouse sphingosine 1-phosphate receptor, S1P5 (Edg-8): structure-activity relationship of sphingosine1-phosphate receptors". Biochemistry. 40 (46): 14053–60. doi:10.1021/bi011606i. PMID 11705398.
  • Takeda S, Kadowaki S, Haga T, Takaesu H, Mitaku S (Jun 2002). "Identification of G protein-coupled receptor genes from the human genome sequence". FEBS Letters. 520 (1–3): 97–101. doi:10.1016/S0014-5793(02)02775-8. PMID 12044878. S2CID 7116392.
  • Niedernberg A, Scherer CR, Busch AE, Kostenis E (Oct 2002). "Comparative analysis of human and rat S1P(5) (edg8): differential expression profiles and sensitivities to antagonists". Biochemical Pharmacology. 64 (8): 1243–50. doi:10.1016/S0006-2952(02)01289-3. PMID 12234605.
  • Kothapalli R, Kusmartseva I, Loughran TP (Dec 2002). "Characterization of a human sphingosine-1-phosphate receptor gene (S1P5) and its differential expression in LGL leukemia". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1579 (2–3): 117–23. doi:10.1016/S0167-4781(02)00529-8. PMID 12427546.
  • Vogler R, Sauer B, Kim DS, Schäfer-Korting M, Kleuser B (Apr 2003). "Sphingosine-1-phosphate and its potentially paradoxical effects on critical parameters of cutaneous wound healing". The Journal of Investigative Dermatology. 120 (4): 693–700. doi:10.1046/j.1523-1747.2003.12096.x. PMID 12648236.
  • Ulfig N, Briese M (2005). "Evidence for the presence of the sphingosine-1-phosphate receptor Edg-8 in human radial glial fibers". Acta Histochemica. 106 (5): 373–8. doi:10.1016/j.acthis.2004.08.002. PMID 15530552.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Research. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
  • Van der Kam E, Turner S, van Bergeij J, Mueller R, Mezler M, Bespalov A, Hobson A, Harris CM, Rendenbach-Mueller B, Schoemaker H (Jun 2014). "The use of selective sphingosine-1-phosphate receptor 5 agonists for the treatment of neurodegenerative disorders such as alzheimer's disease and lysosomal storage diseases such as niemann-pick c disease". Alzheimer's & Dementia. 10: P281. doi:10.1016/j.jalz.2014.07.153. S2CID 54386805.
  • Jenne CN, Enders A, Rivera R, Watson SR, Bankovich AJ, Pereira JP, Xu Y, Roots CM, Beilke JN, Banerjee A, Reiner SL, Miller SA, Weinmann AS, Goodnow CC, Lanier LL, Cyster JG, Chun J (Oct 2009). "T-bet-dependent S1P5 expression in NK cells promotes egress from lymph nodes and bone marrow". J Exp Med. 206 (11): 2469–81. doi:10.1084/jem.20090525. PMC 2768857. PMID 19808259.

External links

  • "Lysophospholipid Receptors: S1P5". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
  • Lysophospholipid+receptors at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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Neurotransmitter
Adrenergic
Purinergic
Serotonin
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Metabolites and
signaling molecules
Eicosanoid
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Peptide
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Miscellaneous
Taste, bitter
Orphan
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Adhesion
Orphan
Other
Taste, sweet
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Class F: Frizzled & Smoothened
Frizzled
Smoothened

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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