P2RY8

Protein-coding gene in the species Homo sapiens
P2RY8
Identifiers
AliasesP2RY8, P2Y8, purinergic receptor P2Y8, P2Y receptor family member 8
External IDsOMIM: 300525 HomoloGene: 65345 GeneCards: P2RY8
Gene location (Human)
X chromosome (human)
Chr.X chromosome (human)[1]
X chromosome (human)
Genomic location for P2RY8
Genomic location for P2RY8
BandX;YStart1,462,581 bp[1]
End1,537,185 bp[1]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • blood

  • bone marrow cells

  • monocyte

  • lymph node

  • trabecular bone

  • appendix

  • spleen

  • superficial temporal artery

  • thymus

  • right lobe of thyroid gland
    n/a
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • G protein-coupled purinergic nucleotide receptor activity
  • signal transducer activity
  • G protein-coupled receptor activity
Cellular component
  • integral component of membrane
  • plasma membrane
  • membrane
  • integral component of plasma membrane
Biological process
  • G protein-coupled receptor signaling pathway
  • signal transduction
  • G protein-coupled purinergic nucleotide receptor signaling pathway
  • positive regulation of Rho protein signal transduction
  • positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

286530

n/a

Ensembl

ENSG00000182162

n/a

UniProt

Q86VZ1

n/a

RefSeq (mRNA)

NM_178129

n/a

RefSeq (protein)

NP_835230

n/a

Location (UCSC)Chr X: 1.46 – 1.54 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

P2Y purinoceptor 8 is a protein that in humans is encoded by the P2RY8 gene.[3][4]

Function

The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are preferentially activated by adenosine and uridine nucleotides. This gene is moderately expressed in undifferentiated HL60 cells, and is located on both chromosomes X and Y.[4]

Clinical relevance

Recurrent mutations in this gene have been associated to cases of diffuse large B-cell lymphoma.[5]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000182162 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ Adrian K, Bernhard MK, Breitinger HG, Ogilvie A (Jun 2000). "Expression of purinergic receptors (ionotropic P2X1-7 and metabotropic P2Y1-11) during myeloid differentiation of HL60 cells". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1492 (1): 127–38. doi:10.1016/S0167-4781(00)00094-4. PMID 11004484.
  4. ^ a b "Entrez Gene: P2RY8 purinergic receptor P2Y, G-protein coupled, 8".
  5. ^ Lohr JG, Stojanov P, Lawrence MS, Auclair D, Chapuy B, Sougnez C, Cruz-Gordillo P, Knoechel B, Asmann YW, Slager SL, Novak AJ, Dogan A, Ansell SM, Link BK, Zou L, Gould J, Saksena G, Stransky N, Rangel-Escareño C, Fernandez-Lopez JC, Hidalgo-Miranda A, Melendez-Zajgla J, Hernández-Lemus E, Schwarz-Cruz y Celis A, Imaz-Rosshandler I, Ojesina AI, Jung J, Pedamallu CS, Lander ES, Habermann TM, Cerhan JR, Shipp MA, Getz G, Golub TR (Mar 2012). "Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing". Proceedings of the National Academy of Sciences of the United States of America. 109 (10): 3879–84. Bibcode:2012PNAS..109.3879L. doi:10.1073/pnas.1121343109. PMC 3309757. PMID 22343534.

Further reading

  • Cantagrel V, Lossi AM, Boulanger S, Depetris D, Mattei MG, Gecz J, Schwartz CE, Van Maldergem L, Villard L (Oct 2004). "Disruption of a new X linked gene highly expressed in brain in a family with two mentally retarded males". Journal of Medical Genetics. 41 (10): 736–42. doi:10.1136/jmg.2004.021626. PMC 1735597. PMID 15466006.
  • Fujiwara S, Yamashita Y, Choi YL, Watanabe H, Kurashina K, Soda M, Enomoto M, Hatanaka H, Takada S, Ozawa K, Mano H (May 2007). "Transforming activity of purinergic receptor P2Y, G protein coupled, 8 revealed by retroviral expression screening". Leukemia & Lymphoma. 48 (5): 978–86. doi:10.1080/10428190701225882. PMID 17487742. S2CID 678068.
  • Storlazzi CT, Albano F, Lo Cunsolo C, Doglioni C, Guastadisegni MC, Impera L, Lonoce A, Funes S, Macrì E, Iuzzolino P, Panagopoulos I, Specchia G, Rocchi M (Oct 2007). "Upregulation of the SOX5 by promoter swapping with the P2RY8 gene in primary splenic follicular lymphoma". Leukemia. 21 (10): 2221–5. doi:10.1038/sj.leu.2404784. PMID 17554380.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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Neurotransmitter
Adrenergic
Purinergic
Serotonin
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Metabolites and
signaling molecules
Eicosanoid
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Peptide
Neuropeptide
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Miscellaneous
Taste, bitter
Orphan
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Adhesion
Orphan
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Taste, sweet
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Class F: Frizzled & Smoothened
Frizzled
Smoothened
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Receptor
(ligands)
P0 (adenine)
P1
(adenosine)
P2
(nucleotide)
P2X
(ATPTooltip Adenosine triphosphate)
P2Y
Transporter
(blockers)
CNTsTooltip Concentrative nucleoside transporters
ENTsTooltip Equilibrative nucleoside transporters
PMATTooltip Plasma membrane monoamine transporter
Enzyme
(inhibitors)
XOTooltip Xanthine oxidase
Others
Others
See also: Receptor/signaling modulators
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