P2RY1

Protein-coding gene in the species Homo sapiens
P2RY1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

4XNV, 4XNW

Identifiers
AliasesP2RY1, P2Y1, purinergic receptor P2Y1, SARCC
External IDsOMIM: 601167 MGI: 105049 HomoloGene: 1926 GeneCards: P2RY1
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for P2RY1
Genomic location for P2RY1
Band3q25.2Start152,835,131 bp[1]
End152,841,439 bp[1]
Gene location (Mouse)
Chromosome 3 (mouse)
Chr.Chromosome 3 (mouse)[2]
Chromosome 3 (mouse)
Genomic location for P2RY1
Genomic location for P2RY1
Band3|3 E1Start60,910,216 bp[2]
End60,916,403 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • endothelial cell

  • oral cavity

  • internal globus pallidus

  • visceral pleura

  • amniotic fluid

  • placenta

  • nucleus accumbens

  • tibia

  • lower lobe of lung

  • secondary oocyte
Top expressed in
  • duodenum

  • islet of Langerhans

  • jejunum

  • esophagus

  • lip

  • ileum

  • colon

  • myocardium of ventricle

  • digastric muscle

  • blood
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • A1 adenosine receptor binding
  • G protein-coupled receptor activity
  • scaffold protein binding
  • ADP binding
  • G protein-coupled purinergic nucleotide receptor activity
  • signal transducer activity
  • protein binding
  • protein heterodimerization activity
  • G protein-coupled ATP receptor activity
  • ATP binding
  • nucleotide binding
  • signaling receptor activity
Cellular component
  • cell body
  • integral component of membrane
  • postsynaptic membrane
  • membrane
  • plasma membrane
  • integral component of plasma membrane
  • cell surface
  • dendrite
  • basolateral plasma membrane
  • apical plasma membrane
  • mitochondrion
  • postsynaptic density
  • glutamatergic synapse
  • integral component of presynaptic active zone membrane
  • cilium
Biological process
  • hemostasis
  • cellular response to organic cyclic compound
  • G protein-coupled adenosine receptor signaling pathway
  • positive regulation of protein phosphorylation
  • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
  • eating behavior
  • positive regulation of cytosolic calcium ion concentration
  • response to mechanical stimulus
  • human ageing
  • regulation of signaling receptor activity
  • negative regulation of norepinephrine secretion
  • signal transduction involved in regulation of gene expression
  • wound healing
  • G protein-coupled purinergic nucleotide receptor signaling pathway
  • phospholipase C-activating G protein-coupled receptor signaling pathway
  • cell surface receptor signaling pathway
  • positive regulation of inositol trisphosphate biosynthetic process
  • negative regulation of binding
  • positive regulation of ion transport
  • positive regulation of ERK1 and ERK2 cascade
  • sensory perception of pain
  • response to growth factor
  • positive regulation of penile erection
  • protein localization to plasma membrane
  • positive regulation of hormone secretion
  • relaxation of muscle
  • positive regulation of transcription by RNA polymerase II
  • glial cell migration
  • signal transduction
  • blood coagulation
  • platelet activation
  • blood vessel diameter maintenance
  • G protein-coupled receptor signaling pathway
  • regulation of cell shape
  • cellular response to ATP
  • cellular response to purine-containing compound
  • regulation of presynaptic cytosolic calcium ion concentration
  • regulation of synaptic vesicle exocytosis
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

5028

18441

Ensembl

ENSG00000169860

ENSMUSG00000027765

UniProt

P47900

P49650

RefSeq (mRNA)

NM_002563

NM_001282016
NM_008772

RefSeq (protein)

NP_002554

NP_001268945
NP_032798

Location (UCSC)Chr 3: 152.84 – 152.84 MbChr 3: 60.91 – 60.92 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

P2Y purinoceptor 1 is a protein that in humans is encoded by the P2RY1 gene.[5]

Function

The product of this gene, P2Y1 belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor functions as a receptor for extracellular ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation.[6]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000169860 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027765 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ayyanathan K, Webbs TE, Sandhu AK, Athwal RS, Barnard EA, Kunapuli SP (January 1996). "Cloning and chromosomal localization of the human P2Y1 purinoceptor". Biochemical and Biophysical Research Communications. 218 (3): 783–8. doi:10.1006/bbrc.1996.0139. PMID 8579591.
  6. ^ "Entrez Gene: P2RY1 purinergic receptor P2Y, G-protein coupled, 1".

Further reading

  • Janssens R, Communi D, Pirotton S, Samson M, Parmentier M, Boeynaems JM (April 1996). "Cloning and tissue distribution of the human P2Y1 receptor". Biochemical and Biophysical Research Communications. 221 (3): 588–93. doi:10.1006/bbrc.1996.0640. PMID 8630005.
  • Léon C, Vial C, Cazenave JP, Gachet C (June 1996). "Cloning and sequencing of a human cDNA encoding endothelial P2Y1 purinoceptor". Gene. 171 (2): 295–7. doi:10.1016/0378-1119(96)00027-3. PMID 8666290.
  • Léon C, Hechler B, Vial C, Leray C, Cazenave JP, Gachet C (February 1997). "The P2Y1 receptor is an ADP receptor antagonized by ATP and expressed in platelets and megakaryoblastic cells". FEBS Letters. 403 (1): 26–30. doi:10.1016/S0014-5793(97)00022-7. PMID 9038354. S2CID 10518131.
  • Ayyanathan K, Naylor SL, Kunapuli SP (September 1996). "Structural characterization and fine chromosomal mapping of the human P2Y1 purinergic receptor gene (P2RY1)". Somatic Cell and Molecular Genetics. 22 (5): 419–24. doi:10.1007/BF02369897. PMID 9039850. S2CID 28971344.
  • Maier R, Glatz A, Mosbacher J, Bilbe G (August 1997). "Cloning of P2Y6 cDNAs and identification of a pseudogene: comparison of P2Y receptor subtype expression in bone and brain tissues". Biochemical and Biophysical Research Communications. 237 (2): 297–302. doi:10.1006/bbrc.1997.7135. PMID 9268704.
  • Jin J, Daniel JL, Kunapuli SP (January 1998). "Molecular basis for ADP-induced platelet activation. II. The P2Y1 receptor mediates ADP-induced intracellular calcium mobilization and shape change in platelets". The Journal of Biological Chemistry. 273 (4): 2030–4. doi:10.1074/jbc.273.4.2030. PMID 9442040.
  • Hall RA, Ostedgaard LS, Premont RT, Blitzer JT, Rahman N, Welsh MJ, Lefkowitz RJ (July 1998). "A C-terminal motif found in the beta2-adrenergic receptor, P2Y1 receptor and cystic fibrosis transmembrane conductance regulator determines binding to the Na+/H+ exchanger regulatory factor family of PDZ proteins". Proceedings of the National Academy of Sciences of the United States of America. 95 (15): 8496–501. Bibcode:1998PNAS...95.8496H. doi:10.1073/pnas.95.15.8496. PMC 21104. PMID 9671706.
  • Sabala P, Czajkowski R, Przybyłek K, Kalita K, Kaczmarek L, Barańska J (January 2001). "Two subtypes of G protein-coupled nucleotide receptors, P2Y(1) and P2Y(2) are involved in calcium signalling in glioma C6 cells". British Journal of Pharmacology. 132 (2): 393–402. doi:10.1038/sj.bjp.0703843. PMC 1572584. PMID 11159687.
  • Yoshioka K, Saitoh O, Nakata H (June 2001). "Heteromeric association creates a P2Y-like adenosine receptor". Proceedings of the National Academy of Sciences of the United States of America. 98 (13): 7617–22. Bibcode:2001PNAS...98.7617Y. doi:10.1073/pnas.121587098. PMC 34717. PMID 11390975.
  • James G, Butt AM (October 2001). "Changes in P2Y and P2X purinoceptors in reactive glia following axonal degeneration in the rat optic nerve". Neuroscience Letters. 312 (1): 33–6. doi:10.1016/S0304-3940(01)02189-9. PMID 11578839. S2CID 30936205.
  • Moore DJ, Chambers JK, Wahlin JP, Tan KB, Moore GB, Jenkins O, Emson PC, Murdock PR (October 2001). "Expression pattern of human P2Y receptor subtypes: a quantitative reverse transcription-polymerase chain reaction study". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1521 (1–3): 107–19. doi:10.1016/S0167-4781(01)00291-3. PMID 11690642.
  • Czajkowski R, Lei L, Sabała P, Barańska J (February 2002). "ADP-evoked phospholipase C stimulation and adenylyl cyclase inhibition in glioma C6 cells occur through two distinct nucleotide receptors, P2Y(1) and P2Y(12)". FEBS Letters. 513 (2–3): 179–83. doi:10.1016/S0014-5793(02)02255-X. PMID 11904146. S2CID 43212335.
  • Aktas B, Hönig-Liedl P, Walter U, Geiger J (August 2002). "Inhibition of platelet P2Y12 and alpha2A receptor signaling by cGMP-dependent protein kinase". Biochemical Pharmacology. 64 (3): 433–9. doi:10.1016/S0006-2952(02)01113-9. PMID 12147294.
  • Nurden P, Poujol C, Winckler J, Combrié R, Pousseau N, Conley PB, Levy-Toledano S, Habib A, Nurden AT (February 2003). "Immunolocalization of P2Y1 and TPalpha receptors in platelets showed a major pool associated with the membranes of alpha -granules and the open canalicular system". Blood. 101 (4): 1400–8. doi:10.1182/blood-2002-02-0642. PMID 12393588. S2CID 30407515.
  • Burrell HE, Bowler WB, Gallagher JA, Sharpe GR (March 2003). "Human keratinocytes express multiple P2Y-receptors: evidence for functional P2Y1, P2Y2, and P2Y4 receptors". The Journal of Investigative Dermatology. 120 (3): 440–7. doi:10.1046/j.1523-1747.2003.12050.x. PMID 12603858.
  • Jagroop IA, Burnstock G, Mikhailidis DP (February 2003). "Both the ADP receptors P2Y1 and P2Y12, play a role in controlling shape change in human platelets". Platelets. 14 (1): 15–20. doi:10.1080/0953710021000062914. PMID 12623443. S2CID 13637415.
  • Greig AV, Linge C, Terenghi G, McGrouther DA, Burnstock G (June 2003). "Purinergic receptors are part of a functional signaling system for proliferation and differentiation of human epidermal keratinocytes". The Journal of Investigative Dermatology. 120 (6): 1007–15. doi:10.1046/j.1523-1747.2003.12261.x. PMID 12787128.
  • Wang L, Ostberg O, Wihlborg AK, Brogren H, Jern S, Erlinge D (February 2003). "Quantification of ADP and ATP receptor expression in human platelets". Journal of Thrombosis and Haemostasis. 1 (2): 330–6. doi:10.1046/j.1538-7836.2003.00070.x. PMID 12871508. S2CID 19101147.

External links

  • "P2Y Receptors: P2Y1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2008-12-09.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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