ATF5

Protein-coding gene in the species Homo sapiens
ATF5
Identifiers
AliasesATF5, ATFX, HMFN0395, activating transcription factor 5
External IDsOMIM: 606398 MGI: 2141857 HomoloGene: 32142 GeneCards: ATF5
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for ATF5
Genomic location for ATF5
Band19q13.33Start49,928,702 bp[1]
End49,933,935 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for ATF5
Genomic location for ATF5
Band7|7 B3Start44,461,680 bp[2]
End44,466,082 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right lobe of liver

  • gastric mucosa

  • left adrenal gland

  • vena cava

  • monocyte

  • appendix

  • body of stomach

  • subcutaneous adipose tissue

  • gastrocnemius muscle

  • left coronary artery
Top expressed in
  • olfactory epithelium

  • left lobe of liver

  • lip

  • esophagus

  • molar

  • calvaria

  • ankle

  • plantaris muscle

  • extensor digitorum longus muscle

  • brown adipose tissue
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • sequence-specific DNA binding
  • DNA binding
  • RNA polymerase II transcription regulatory region sequence-specific DNA binding
  • transcription corepressor activity
  • DNA-binding transcription factor activity
  • DNA-binding transcription activator activity, RNA polymerase II-specific
  • chromatin binding
  • tubulin binding
  • kinase binding
  • protein binding
  • DNA-binding transcription factor activity, RNA polymerase II-specific
Cellular component
  • centrosome
  • transcription regulator complex
  • nucleoplasm
  • microtubule organizing center
  • cytoskeleton
  • nucleus
  • cytoplasm
  • cytosol
Biological process
  • negative regulation of cell cycle G2/M phase transition
  • regulation of transcription, DNA-templated
  • olfactory bulb interneuron differentiation
  • multicellular organism growth
  • regulation of transcription by RNA polymerase II
  • negative regulation of apoptotic process
  • post-embryonic development
  • transcription, DNA-templated
  • cerebellar granule cell precursor proliferation
  • positive regulation of transcription, DNA-templated
  • regulation of centrosome cycle
  • circadian rhythm
  • olfactory bulb interneuron development
  • regulation of gene expression
  • olfactory lobe development
  • negative regulation of transcription, DNA-templated
  • fat cell differentiation
  • positive regulation of transcription by RNA polymerase II
  • negative regulation of cell population proliferation
  • transcription by RNA polymerase II
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

22809

107503

Ensembl

ENSG00000169136

ENSMUSG00000038539

UniProt

Q9Y2D1

O70191

RefSeq (mRNA)

NM_001193646
NM_001290746
NM_012068

NM_030693

RefSeq (protein)

NP_001180575
NP_001277675
NP_036200

NP_109618

Location (UCSC)Chr 19: 49.93 – 49.93 MbChr 7: 44.46 – 44.47 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Activating transcription factor 5, also known as ATF5, is a protein that, in humans, is encoded by the ATF5 gene.[5]

Function

First described by Nishizawa and Nagata,[6] ATF5 has been classified as a member of the activating transcription factor (ATF)/cAMP response-element binding protein (CREB) family.[7][8]

ATF5 transcripts and protein are expressed in a wide variety of tissues, in particular, high expression of transcripts in liver. It is also present in a variety of tumor cell types.

ATF5 expression is regulated at both the transcriptional and translational level.

ATF5 is expressed in VZ and SVZ during brain development.

The human ATF5 protein is made up of 282 amino acids.

ATF5 is a transcription factor that contains a bZip domain.

See also

Interactions

ATF5 has been shown to interact with DISC1[9] and TRIB3.[10]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000169136 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038539 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: ATF5 activating transcription factor 5".
  6. ^ Pati D, Meistrich ML, Plon SE (July 1999). "Human Cdc34 and Rad6B ubiquitin-conjugating enzymes target repressors of cyclic AMP-induced transcription for proteolysis". Mol. Cell. Biol. 19 (7): 5001–13. doi:10.1128/mcb.19.7.5001. PMC 84326. PMID 10373550.
  7. ^ Hai T, Hartman MG (July 2001). "The molecular biology and nomenclature of the activating transcription factor/cAMP responsive element binding family of transcription factors: activating transcription factor proteins and homeostasis". Gene. 273 (1): 1–11. doi:10.1016/S0378-1119(01)00551-0. PMID 11483355.
  8. ^ Vinson C, Myakishev M, Acharya A, Mir AA, Moll JR, Bonovich M (September 2002). "Classification of human B-ZIP proteins based on dimerization properties". Mol. Cell. Biol. 22 (18): 6321–6335. doi:10.1128/MCB.22.18.6321-6335.2002. PMC 135624. PMID 12192032.
  9. ^ Morris JA, Kandpal G, Ma L, Austin CP (Jul 2003). "DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation". Hum. Mol. Genet. 12 (13): 1591–1608. doi:10.1093/hmg/ddg162. PMID 12812986.
  10. ^ Zhou Y, Li L, Liu Q, Xing G, Kuai X, Sun J, Yin X, Wang J, Zhang L, He F (May 2008). "E3 ubiquitin ligase SIAH1 mediates ubiquitination and degradation of TRB3". Cell. Signal. 20 (5): 942–948. doi:10.1016/j.cellsig.2008.01.010. PMID 18276110.

Further reading

  • Pati D, Meistrich ML, Plon SE (1999). "Human Cdc34 and Rad6B ubiquitin-conjugating enzymes target repressors of cyclic AMP-induced transcription for proteolysis". Mol. Cell. Biol. 19 (7): 5001–13. doi:10.1128/mcb.19.7.5001. PMC 84326. PMID 10373550.
  • White JH, McIllhinney RA, Wise A, Ciruela F, Chan WY, Emson PC, Billinton A, Marshall FH (2001). "The GABAB receptor interacts directly with the related transcription factors CREB2 and ATFx". Proc. Natl. Acad. Sci. U.S.A. 97 (25): 13967–13972. doi:10.1073/pnas.240452197. PMC 17684. PMID 11087824.
  • Peters CS, Liang X, Li S, Kannan S, Peng Y, Taub R, Diamond RH (2001). "ATF-7, a novel bZIP protein, interacts with the PRL-1 protein-tyrosine phosphatase". J. Biol. Chem. 276 (17): 13718–26. doi:10.1074/jbc.M011562200. PMID 11278933.
  • Morris JA, Kandpal G, Ma L, Austin CP (2004). "DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation". Hum. Mol. Genet. 12 (13): 1591–1608. doi:10.1093/hmg/ddg162. PMID 12812986.
  • Yamada S, Ohira M, Horie H, Ando K, Takayasu H, Suzuki Y, Sugano S, Hirata T, Goto T, Matsunaga T, Hiyama E, Hayashi Y, Ando H, Suita S, Kaneko M, Sasaki F, Hashizume K, Ohnuma N, Nakagawara A (2004). "Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas". Oncogene. 23 (35): 5901–5911. doi:10.1038/sj.onc.1207782. PMID 15221005. S2CID 3114318.
  • Liu W, Sun M, Jiang J, Shen X, Sun Q, Liu W, Shen H, Gu J (2004). "Cyclin D3 interacts with human activating transcription factor 5 and potentiates its transcription activity". Biochem. Biophys. Res. Commun. 321 (4): 954–960. doi:10.1016/j.bbrc.2004.07.053. PMID 15358120.
  • Forgacs E, Gupta SK, Kerry JA, Semmes OJ (2005). "The bZIP transcription factor ATFx binds human T-cell leukemia virus type 1 (HTLV-1) Tax and represses HTLV-1 long terminal repeat-mediated transcription". J. Virol. 79 (11): 6932–6939. doi:10.1128/JVI.79.11.6932-6939.2005. PMC 1112100. PMID 15890932.
  • Al Sarraj J, Vinson C, Thiel G (2005). "Regulation of asparagine synthetase gene transcription by the basic region leucine zipper transcription factors ATF5 and CHOP". Biol. Chem. 386 (9): 873–879. doi:10.1515/BC.2005.102. PMID 16164412. S2CID 24061972.
  • Angelastro JM, Canoll PD, Kuo J, Weicker M, Costa A, Bruce JN, Greene LA (2006). "Selective destruction of glioblastoma cells by interference with the activity or expression of ATF5". Oncogene. 25 (6): 907–916. doi:10.1038/sj.onc.1209116. PMID 16170340. S2CID 19581052.
  • Wei Y, Jiang J, Sun M, Chen X, Wang H, Gu J (2006). "ATF5 increases cisplatin-induced apoptosis through up-regulation of cyclin D3 transcription in HeLa cells". Biochem. Biophys. Res. Commun. 339 (2): 591–596. doi:10.1016/j.bbrc.2005.11.054. PMID 16300731.
  • Kakiuchi C, Ishiwata M, Nanko S, Kunugi H, Minabe Y, Nakamura K, Mori N, Fujii K, Yamada K, Yoshikawa T, Kato T (2007). "Association analysis of ATF4 and ATF5, genes for interacting-proteins of DISC1, in bipolar disorder". Neurosci. Lett. 417 (3): 316–321. doi:10.1016/j.neulet.2007.02.054. PMID 17346882. S2CID 7488805.
  • Watatani Y, Ichikawa K, Nakanishi N, Fujimoto M, Takeda H, Kimura N, Hirose H, Takahashi S, Takahashi Y (2008). "Stress-induced translation of ATF5 mRNA is regulated by the 5'-untranslated region". J. Biol. Chem. 283 (5): 2543–2553. doi:10.1074/jbc.M707781200. PMID 18055463.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
(1.2) Basic helix-loop-helix (bHLH)
Group A
Group B
Group C
bHLH-PAS
Group D
Group E
Group F
bHLH-COE
(1.3) bHLH-ZIP
(1.4) NF-1
(1.5) RF-X
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1
subfamily 2
subfamily 3
subfamily 4
subfamily 5
subfamily 6
subfamily 0
(2.2) Other Cys4
(2.3) Cys2His2
(2.4) Cys6
(2.5) Alternating composition
(2.6) WRKY
(3) Helix-turn-helix domains
(3.1) Homeodomain
Antennapedia
ANTP class
protoHOX
Hox-like
metaHOX
NK-like
other
(3.2) Paired box
(3.3) Fork head / winged helix
(3.4) Heat shock factors
(3.5) Tryptophan clusters
(3.6) TEA domain
  • transcriptional enhancer factor
(4) β-Scaffold factors with minor groove contacts
(4.1) Rel homology region
(4.2) STAT
(4.3) p53-like
(4.4) MADS box
(4.6) TATA-binding proteins
(4.7) High-mobility group
(4.9) Grainyhead
(4.10) Cold-shock domain
(4.11) Runt
(0) Other transcription factors
(0.2) HMGI(Y)
(0.3) Pocket domain
(0.5) AP-2/EREBP-related factors
(0.6) Miscellaneous
see also transcription factor/coregulator deficiencies
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Inhibits
NGF


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