MLLT1

Protein-coding gene in the species Homo sapiens
MLLT1
Identifiers
AliasesMLLT1, ENL, LTG19, YEATS1, myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1, super elongation complex subunit, MLLT1 super elongation complex subunit
External IDsOMIM: 159556 MGI: 1927238 HomoloGene: 4339 GeneCards: MLLT1
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for MLLT1
Genomic location for MLLT1
Band19p13.3Start6,210,381 bp[1]
End6,279,975 bp[1]
Gene location (Mouse)
Chromosome 17 (mouse)
Chr.Chromosome 17 (mouse)[2]
Chromosome 17 (mouse)
Genomic location for MLLT1
Genomic location for MLLT1
Band17|17 DStart57,199,611 bp[2]
End57,242,415 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • placenta

  • right uterine tube

  • tibialis anterior muscle

  • nucleus accumbens

  • oocyte

  • lower lobe of lung

  • left uterine tube

  • postcentral gyrus

  • amygdala

  • canal of the cervix
Top expressed in
  • lip

  • superior frontal gyrus

  • neural tube

  • entorhinal cortex

  • maxillary prominence

  • spermatid

  • ganglionic eminence

  • spermatocyte

  • thymus

  • seminiferous tubule
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • DNA binding
  • protein binding
  • DNA-binding transcription factor activity, RNA polymerase II-specific
Cellular component
  • transcription elongation factor complex
  • nucleus
  • fibrillar center
  • nucleoplasm
  • cytosol
Biological process
  • regulation of transcription, DNA-templated
  • transcription by RNA polymerase II
  • negative regulation of protein kinase activity
  • transcription, DNA-templated
  • transcription elongation from RNA polymerase II promoter
  • regulation of transcription by RNA polymerase II
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

4298

64144

Ensembl

ENSG00000130382

ENSMUSG00000024212

UniProt

Q03111

Q9ERL0

RefSeq (mRNA)

NM_005934

NM_022328

RefSeq (protein)

NP_005925

NP_071723

Location (UCSC)Chr 19: 6.21 – 6.28 MbChr 17: 57.2 – 57.24 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protein ENL is a protein that in humans is encoded by the MLLT1 gene.[5]


Interactions

MLLT1 has been shown to interact with CBX8.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000130382 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024212 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: MLLT1 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1".
  6. ^ García-Cuéllar MP, Zilles O, Schreiner SA, Birke M, Winkler TH, Slany RK (January 2001). "The ENL moiety of the childhood leukemia-associated MLL-ENL oncoprotein recruits human Polycomb 3". Oncogene. 20 (4): 411–9. doi:10.1038/sj.onc.1204108. PMID 11313972.

Further reading

  • Tkachuk DC, Kohler S, Cleary ML (November 1992). "Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias". Cell. 71 (4): 691–700. doi:10.1016/0092-8674(92)90602-9. PMID 1423624. S2CID 11801536.
  • Thirman MJ, Levitan DA, Kobayashi H, Simon MC, Rowley JD (December 1994). "Cloning of ELL, a gene that fuses to MLL in a t(11;19)(q23;p13.1) in acute myeloid leukemia". Proceedings of the National Academy of Sciences of the United States of America. 91 (25): 12110–4. Bibcode:1994PNAS...9112110T. doi:10.1073/pnas.91.25.12110. PMC 45386. PMID 7991593.
  • Rubnitz JE, Morrissey J, Savage PA, Cleary ML (September 1994). "ENL, the gene fused with HRX in t(11;19) leukemias, encodes a nuclear protein with transcriptional activation potential in lymphoid and myeloid cells". Blood. 84 (6): 1747–52. doi:10.1182/blood.V84.6.1747.1747. PMID 8080983.
  • Yamamoto K, Seto M, Komatsu H, Iida S, Akao Y, Kojima S, Kodera Y, Nakazawa S, Ariyoshi Y, Takahashi T (October 1993). "Two distinct portions of LTG19/ENL at 19p13 are involved in t(11;19) leukemia". Oncogene. 8 (10): 2617–25. PMID 8378076.
  • Lavau C, Luo RT, Du C, Thirman MJ (September 2000). "Retrovirus-mediated gene transfer of MLL-ELL transforms primary myeloid progenitors and causes acute myeloid leukemias in mice". Proceedings of the National Academy of Sciences of the United States of America. 97 (20): 10984–9. Bibcode:2000PNAS...9710984L. doi:10.1073/pnas.190167297. PMC 27135. PMID 10995463.
  • García-Cuéllar MP, Zilles O, Schreiner SA, Birke M, Winkler TH, Slany RK (January 2001). "The ENL moiety of the childhood leukemia-associated MLL-ENL oncoprotein recruits human Polycomb 3". Oncogene. 20 (4): 411–9. doi:10.1038/sj.onc.1204108. PMID 11313972.
  • Nie Z, Yan Z, Chen EH, Sechi S, Ling C, Zhou S, Xue Y, Yang D, Murray D, Kanakubo E, Cleary ML, Wang W (April 2003). "Novel SWI/SNF chromatin-remodeling complexes contain a mixed-lineage leukemia chromosomal translocation partner". Molecular and Cellular Biology. 23 (8): 2942–52. doi:10.1128/MCB.23.8.2942-2952.2003. PMC 152562. PMID 12665591.
  • Gué M, Sun JS, Boudier T (January 2006). "Simultaneous localization of MLL, AF4 and ENL genes in interphase nuclei by 3D-FISH: MLL translocation revisited". BMC Cancer. 6: 20. doi:10.1186/1471-2407-6-20. PMC 1388228. PMID 16433901.
  • Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
  • Meyer C, Burmeister T, Strehl S, Schneider B, Hubert D, Zach O, Haas O, Klingebiel T, Dingermann T, Marschalek R (March 2007). "Spliced MLL fusions: a novel mechanism to generate functional chimeric MLL-MLLT1 transcripts in t(11;19)(q23;p13.3) leukemia". Leukemia. 21 (3): 588–90. doi:10.1038/sj.leu.2404542. PMID 17252016. S2CID 34843802.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
(1.2) Basic helix-loop-helix (bHLH)
Group A
Group B
Group C
bHLH-PAS
Group D
Group E
Group F
bHLH-COE
(1.3) bHLH-ZIP
(1.4) NF-1
(1.5) RF-X
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1
subfamily 2
subfamily 3
subfamily 4
subfamily 5
subfamily 6
subfamily 0
(2.2) Other Cys4
(2.3) Cys2His2
(2.4) Cys6
(2.5) Alternating composition
(2.6) WRKY
(3) Helix-turn-helix domains
(3.1) Homeodomain
Antennapedia
ANTP class
protoHOX
Hox-like
metaHOX
NK-like
other
(3.2) Paired box
(3.3) Fork head / winged helix
(3.4) Heat shock factors
(3.5) Tryptophan clusters
(3.6) TEA domain
  • transcriptional enhancer factor
(4) β-Scaffold factors with minor groove contacts
(4.1) Rel homology region
(4.2) STAT
(4.3) p53-like
(4.4) MADS box
(4.6) TATA-binding proteins
(4.7) High-mobility group
(4.9) Grainyhead
(4.10) Cold-shock domain
(4.11) Runt
(0) Other transcription factors
(0.2) HMGI(Y)
(0.3) Pocket domain
(0.5) AP-2/EREBP-related factors
(0.6) Miscellaneous
see also transcription factor/coregulator deficiencies
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