PRRX2

Protein-coding gene in the species Homo sapiens
PRRX2
Identifiers
AliasesPRRX2, PMX2, PRX2, paired related homeobox 2
External IDsOMIM: 604675 MGI: 98218 HomoloGene: 7524 GeneCards: PRRX2
Gene location (Human)
Chromosome 9 (human)
Chr.Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for PRRX2
Genomic location for PRRX2
Band9q34.11Start129,665,647 bp[1]
End129,722,674 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for PRRX2
Genomic location for PRRX2
Band2 B|2 21.74 cMStart30,724,984 bp[2]
End30,771,263 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • ascending aorta

  • periodontal fiber

  • vena cava

  • canal of the cervix

  • right coronary artery

  • left coronary artery

  • skin of abdomen

  • pericardium

  • vulva

  • trachea
Top expressed in
  • hand

  • calvaria

  • maxillary prominence

  • external carotid artery

  • nasal septum

  • dermis

  • foot

  • abdominal wall

  • somite

  • lip
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • DNA-binding transcription factor activity
  • sequence-specific DNA binding
  • DNA binding
  • DNA-binding transcription factor activity, RNA polymerase II-specific
Cellular component
  • nucleus
Biological process
  • multicellular organism development
  • regulation of transcription, DNA-templated
  • regulation of transcription by RNA polymerase II
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

51450

20204

Ensembl

ENSG00000167157

ENSMUSG00000039476

UniProt

Q99811

Q06348

RefSeq (mRNA)

NM_016307

NM_009116

RefSeq (protein)

NP_057391

NP_033142

Location (UCSC)Chr 9: 129.67 – 129.72 MbChr 2: 30.72 – 30.77 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Paired mesoderm homeobox protein 2 is a protein that in humans is encoded by the PRRX2 gene.[5][6]

Function

The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins. Expression is localized to proliferating fetal fibroblasts and the developing dermal layer, with downregulated expression in adult skin. Increases in expression of this gene during fetal but not adult wound healing suggest a possible role in mechanisms that control mammalian dermal regeneration and prevent formation of scar response to wounding. The expression patterns provide evidence consistent with a role in fetal skin development and a possible role in cellular proliferation.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000167157 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000039476 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Norris RA, Scott KK, Moore CS, Stetten G, Brown CR, Jabs EW, Wulfsberg EA, Yu J, Kern MJ (Mar 2001). "Human PRRX1 and PRRX2 genes: cloning, expression, genomic localization, and exclusion as disease genes for Nager syndrome". Mamm Genome. 11 (11): 1000–5. doi:10.1007/s003350010193. PMID 11063257. S2CID 9937434.
  6. ^ a b "Entrez Gene: PRRX2 paired related homeobox 2".

Further reading

  • Tokutomi Y, Araki N, Kataoka K, et al. (2007). "Oxidation of Prx2 and phosphorylation of GRP58 by angiotensin II in human coronary smooth muscle cells identified by 2D-DIGE analysis". Biochem. Biophys. Res. Commun. 364 (4): 822–30. doi:10.1016/j.bbrc.2007.10.095. PMID 17964282.
  • Wissmüller S, Kosian T, Wolf M, et al. (2006). "The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors". Nucleic Acids Res. 34 (6): 1735–44. doi:10.1093/nar/gkl105. PMC 1421504. PMID 16582099.
  • Gervais C, Mauvieux L, Perrusson N, et al. (2005). "A new translocation t(9;11)(q34;p15) fuses NUP98 to a novel homeobox partner gene, PRRX2, in a therapy-related acute myeloid leukemia". Leukemia. 19 (1): 145–8. doi:10.1038/sj.leu.2403565. PMID 15496970.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Scott KK, Norris RA, Potter SS, et al. (2003). "GeneChip microarrays facilitate identification of Protease Nexin-1 as a target gene of the Prx2 (S8) homeoprotein". DNA Cell Biol. 22 (2): 95–105. doi:10.1089/104454903321515904. PMID 12713735.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Jones FS, McKean DM, Meech R, et al. (2002). "Regulation of vascular smooth muscle cell growth and adhesion by paired-related homeobox genes". Chest. 121 (3 Suppl): 89S–90S. doi:10.1378/chest.121.3_suppl.89S-a. PMID 11893718.
  • Stelnicki EJ, Arbeit J, Cass DL, et al. (1998). "Modulation of the human homeobox genes PRX-2 and HOXB13 in scarless fetal wounds". J. Invest. Dermatol. 111 (1): 57–63. doi:10.1046/j.1523-1747.1998.00238.x. PMID 9665387.
  • v
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(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
(1.2) Basic helix-loop-helix (bHLH)
Group A
Group B
Group C
bHLH-PAS
Group D
Group E
Group F
bHLH-COE
(1.3) bHLH-ZIP
(1.4) NF-1
(1.5) RF-X
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1
subfamily 2
subfamily 3
subfamily 4
subfamily 5
subfamily 6
subfamily 0
(2.2) Other Cys4
(2.3) Cys2His2
(2.4) Cys6
(2.5) Alternating composition
(2.6) WRKY
(3) Helix-turn-helix domains
(3.1) Homeodomain
Antennapedia
ANTP class
protoHOX
Hox-like
metaHOX
NK-like
other
(3.2) Paired box
(3.3) Fork head / winged helix
(3.4) Heat shock factors
(3.5) Tryptophan clusters
(3.6) TEA domain
  • transcriptional enhancer factor
(4) β-Scaffold factors with minor groove contacts
(4.1) Rel homology region
(4.2) STAT
(4.3) p53-like
(4.4) MADS box
(4.6) TATA-binding proteins
(4.7) High-mobility group
(4.9) Grainyhead
(4.10) Cold-shock domain
(4.11) Runt
(0) Other transcription factors
(0.2) HMGI(Y)
(0.3) Pocket domain
(0.5) AP-2/EREBP-related factors
(0.6) Miscellaneous
see also transcription factor/coregulator deficiencies


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