ZNF593

Protein-coding gene in the species Homo sapiens
ZNF593
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1ZR9

Identifiers
AliasesZNF593, ZT86, zinc finger protein 593
External IDsOMIM: 616698 MGI: 1915290 HomoloGene: 41070 GeneCards: ZNF593
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for ZNF593
Genomic location for ZNF593
Band1p36.11Start26,169,908 bp[1]
End26,170,873 bp[1]
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)[2]
Chromosome 4 (mouse)
Genomic location for ZNF593
Genomic location for ZNF593
Band4|4 D2.3Start133,970,600 bp[2]
End133,972,903 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • gastrocnemius muscle

  • body of pancreas

  • right lobe of liver

  • body of stomach

  • oocyte

  • left adrenal gland

  • left ventricle

  • left uterine tube

  • anterior pituitary

  • left lobe of thyroid gland
Top expressed in
  • Paneth cell

  • hair follicle

  • primitive streak

  • condyle

  • seminal vesicula

  • fossa

  • facial motor nucleus

  • external carotid artery

  • internal carotid artery

  • conjunctival fornix
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • DNA binding
  • protein binding
  • metal ion binding
  • nucleic acid binding
  • acyl binding
  • acyl carrier activity
  • phosphopantetheine binding
  • ribosomal large subunit binding
  • zinc ion binding
  • DNA-binding transcription factor activity, RNA polymerase II-specific
Cellular component
  • nucleolus
  • nucleus
  • cytosol
  • preribosome, large subunit precursor
Biological process
  • regulation of transcription, DNA-templated
  • transcription, DNA-templated
  • ribosomal large subunit export from nucleus
  • lipid A biosynthetic process
  • positive regulation of transcription by RNA polymerase II
  • negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding
  • fatty acid biosynthetic process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

51042

68040

Ensembl

ENSG00000142684

ENSMUSG00000028840

UniProt

O00488

Q9DB42

RefSeq (mRNA)

NM_015871

NM_024215

RefSeq (protein)

NP_056955

NP_077177

Location (UCSC)Chr 1: 26.17 – 26.17 MbChr 4: 133.97 – 133.97 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Zinc finger protein 593 is a protein that in humans is encoded by the ZNF593 gene.[5][6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000142684 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028840 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Terunuma A, Shiba K, Noda T (Jun 1997). "A novel genetic system to isolate a dominant negative effector on DNA-binding activity of Oct-2". Nucleic Acids Res. 25 (10): 1984–90. doi:10.1093/nar/25.10.1984. PMC 146677. PMID 9115366.
  6. ^ "Entrez Gene: ZNF593 zinc finger protein 593".

Further reading

  • Scherl A, Couté Y, Déon C, et al. (2003). "Functional proteomic analysis of human nucleolus". Mol. Biol. Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • v
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  • 1zr9: Solution Structure of a Human C2H2-type Zinc Finger Protein
    1zr9: Solution Structure of a Human C2H2-type Zinc Finger Protein

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
(1.2) Basic helix-loop-helix (bHLH)
Group A
Group B
Group C
bHLH-PAS
Group D
Group E
Group F
bHLH-COE
(1.3) bHLH-ZIP
(1.4) NF-1
(1.5) RF-X
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1
subfamily 2
subfamily 3
subfamily 4
subfamily 5
subfamily 6
subfamily 0
(2.2) Other Cys4
(2.3) Cys2His2
(2.4) Cys6
(2.5) Alternating composition
(2.6) WRKY
(3) Helix-turn-helix domains
(3.1) Homeodomain
Antennapedia
ANTP class
protoHOX
Hox-like
metaHOX
NK-like
other
(3.2) Paired box
(3.3) Fork head / winged helix
(3.4) Heat shock factors
(3.5) Tryptophan clusters
(3.6) TEA domain
  • transcriptional enhancer factor
(4) β-Scaffold factors with minor groove contacts
(4.1) Rel homology region
(4.2) STAT
(4.3) p53-like
(4.4) MADS box
(4.6) TATA-binding proteins
(4.7) High-mobility group
(4.9) Grainyhead
(4.10) Cold-shock domain
(4.11) Runt
(0) Other transcription factors
(0.2) HMGI(Y)
(0.3) Pocket domain
(0.5) AP-2/EREBP-related factors
(0.6) Miscellaneous
see also transcription factor/coregulator deficiencies
Stub icon

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