PHF16

Protein-coding gene in the species Homo sapiens
JADE3
Identifiers
AliasesJADE3, JADE-3, PHF16, jade family PHD finger 3
External IDsOMIM: 300618 MGI: 2148019 HomoloGene: 40981 GeneCards: JADE3
Gene location (Human)
X chromosome (human)
Chr.X chromosome (human)[1]
X chromosome (human)
Genomic location for JADE3
Genomic location for JADE3
BandXp11.3Start46,912,276 bp[1]
End47,061,242 bp[1]
Gene location (Mouse)
X chromosome (mouse)
Chr.X chromosome (mouse)[2]
X chromosome (mouse)
Genomic location for JADE3
Genomic location for JADE3
BandX|X A1.3Start20,291,927 bp[2]
End20,386,178 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • corpus epididymis

  • caput epididymis

  • placenta

  • seminal vesicula

  • ganglionic eminence

  • secondary oocyte

  • left adrenal gland

  • body of pancreas

  • visceral pleura

  • germinal epithelium
Top expressed in
  • superior cervical ganglion

  • yolk sac

  • medullary collecting duct

  • cumulus cell

  • primitive streak

  • ovary

  • islet of Langerhans

  • urothelium

  • hand

  • ureter
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
  • metal ion binding
Cellular component
  • histone acetyltransferase complex
Biological process
  • histone H4-K16 acetylation
  • histone H4-K8 acetylation
  • histone H4-K12 acetylation
  • histone H3 acetylation
  • histone H4-K5 acetylation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9767

382207

Ensembl

ENSG00000102221

ENSMUSG00000037315

UniProt

Q92613

Q6IE82

RefSeq (mRNA)

NM_014735
NM_001077445

NM_001289684
NM_199317

RefSeq (protein)

NP_001070913
NP_055550

NP_001276613
NP_955021
NP_001393168
NP_001393169
NP_001393170

Location (UCSC)Chr X: 46.91 – 47.06 MbChr X: 20.29 – 20.39 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protein Jade-3 is a protein that in humans is encoded by the PHF16 gene.[5][6]

This gene is part of a gene cluster on chromosome Xp11.23. The encoded protein contains a zinc finger motif often found in transcriptional regulators, however, its exact function is not known. Alternative splicing results in multiple transcript variants encoding the same protein.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000102221 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037315 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Thiselton DL, McDowall J, Brandau O, Ramser J, d'Esposito F, Bhattacharya SS, Ross MT, Hardcastle AJ, Meindl A (Apr 2002). "An integrated, functionally annotated gene map of the DXS8026-ELK1 interval on human Xp11.3-Xp11.23: potential hotspot for neurogenetic disorders". Genomics. 79 (4): 560–72. doi:10.1006/geno.2002.6733. PMID 11944989.
  6. ^ a b "Entrez Gene: PHF16 PHD finger protein 16".

Further reading

  • Nagase T, Seki N, Ishikawa K, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Res. 3 (5): 321–9, 341–54. doi:10.1093/dnares/3.5.321. PMID 9039502.
  • Szelei J, Soto AM, Geck P, et al. (2000). "Identification of human estrogen-inducible transcripts that potentially mediate the apoptotic response in breast cancer". J. Steroid Biochem. Mol. Biol. 72 (3–4): 89–102. doi:10.1016/S0960-0760(00)00025-X. PMID 10775800. S2CID 25912630.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Tzouanacou E, Tweedie S, Wilson V (2003). "Identification of Jade1, a gene encoding a PHD zinc finger protein, in a gene trap mutagenesis screen for genes involved in anteroposterior axis development". Mol. Cell. Biol. 23 (23): 8553–2. doi:10.1128/MCB.23.23.8553-8562.2003. PMC 262661. PMID 14612400.
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. Bibcode:2005Natur.434..325R. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

  • v
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(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
(1.2) Basic helix-loop-helix (bHLH)
Group A
Group B
Group C
bHLH-PAS
Group D
Group E
Group F
bHLH-COE
(1.3) bHLH-ZIP
(1.4) NF-1
(1.5) RF-X
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1
subfamily 2
subfamily 3
subfamily 4
subfamily 5
subfamily 6
subfamily 0
(2.2) Other Cys4
(2.3) Cys2His2
(2.4) Cys6
(2.5) Alternating composition
(2.6) WRKY
(3) Helix-turn-helix domains
(3.1) Homeodomain
Antennapedia
ANTP class
protoHOX
Hox-like
metaHOX
NK-like
other
(3.2) Paired box
(3.3) Fork head / winged helix
(3.4) Heat shock factors
(3.5) Tryptophan clusters
(3.6) TEA domain
  • transcriptional enhancer factor
(4) β-Scaffold factors with minor groove contacts
(4.1) Rel homology region
(4.2) STAT
(4.3) p53-like
(4.4) MADS box
(4.6) TATA-binding proteins
(4.7) High-mobility group
(4.9) Grainyhead
(4.10) Cold-shock domain
(4.11) Runt
(0) Other transcription factors
(0.2) HMGI(Y)
(0.3) Pocket domain
(0.5) AP-2/EREBP-related factors
(0.6) Miscellaneous
see also transcription factor/coregulator deficiencies


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