Hepatocyte nuclear factor 4 gamma

Protein-coding gene in the species Homo sapiens
HNF4G
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1LV2

Identifiers
AliasesHNF4G, NR2A2, NR2A3, Hepatocyte nuclear factor 4 gamma
External IDsOMIM: 605966 MGI: 1353604 HomoloGene: 37886 GeneCards: HNF4G
Gene location (Human)
Chromosome 8 (human)
Chr.Chromosome 8 (human)[1]
Chromosome 8 (human)
Genomic location for HNF4G
Genomic location for HNF4G
Band8q21.13Start75,407,914 bp[1]
End75,566,834 bp[1]
Gene location (Mouse)
Chromosome 3 (mouse)
Chr.Chromosome 3 (mouse)[2]
Chromosome 3 (mouse)
Genomic location for HNF4G
Genomic location for HNF4G
Band3|3 A1Start3,573,090 bp[2]
End3,723,112 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • jejunal mucosa

  • duodenum

  • rectum

  • gallbladder

  • right lobe of liver

  • body of pancreas

  • islet of Langerhans

  • Achilles tendon

  • bronchial epithelial cell

  • kidney
Top expressed in
  • duodenum

  • jejunum

  • urethra

  • ileum

  • male urethra

  • proximal tubule

  • intestinal villus

  • crypt of lieberkuhn of small intestine

  • colon

  • stomach
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • DNA-binding transcription factor activity
  • steroid hormone receptor activity
  • sequence-specific DNA binding
  • DNA binding
  • nuclear receptor activity
  • zinc ion binding
  • metal ion binding
  • RNA polymerase II cis-regulatory region sequence-specific DNA binding
  • DNA-binding transcription activator activity, RNA polymerase II-specific
  • DNA-binding transcription factor activity, RNA polymerase II-specific
Cellular component
  • nucleus
  • nucleoplasm
Biological process
  • regulation of transcription by RNA polymerase II
  • intracellular receptor signaling pathway
  • transcription initiation from RNA polymerase II promoter
  • regulation of transcription, DNA-templated
  • transcription, DNA-templated
  • steroid hormone mediated signaling pathway
  • positive regulation of transcription by RNA polymerase II
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

3174

30942

Ensembl

ENSG00000164749

ENSMUSG00000017688

UniProt

Q14541

Q9WUU6

RefSeq (mRNA)

NM_004133
NM_001330561

NM_013920
NM_001395870

RefSeq (protein)

NP_001317490
NP_004124

NP_038948
NP_001382799

Location (UCSC)Chr 8: 75.41 – 75.57 MbChr 3: 3.57 – 3.72 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Hepatocyte nuclear factor 4 gamma (HNF4G) also known as NR2A2 (nuclear receptor subfamily 2, group A, member 2) is a nuclear receptor that in humans is encoded by the HNF4G gene.[5][6][7]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000164749 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000017688 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: HNF4G hepatocyte nuclear factor 4, gamma".
  6. ^ Drewes T, Senkel S, Holewa B, Ryffel GU (March 1996). "Human hepatocyte nuclear factor 4 isoforms are encoded by distinct and differentially expressed genes". Molecular and Cellular Biology. 16 (3): 925–31. doi:10.1128/mcb.16.3.925. PMC 231074. PMID 8622695.
  7. ^ Wisely GB, Miller AB, Davis RG, Thornquest AD, Johnson R, Spitzer T, Sefler A, Shearer B, Moore JT, Miller AB, Willson TM, Williams SP (September 2002). "Hepatocyte nuclear factor 4 is a transcription factor that constitutively binds fatty acids". Structure. 10 (9): 1225–34. doi:10.1016/S0969-2126(02)00829-8. PMID 12220494.

Further reading

  • Plengvidhya N, Antonellis A, Wogan LT, Poleev A, Borgschulze M, Warram JH, Ryffel GU, Krolewski AS, Doria A (October 1999). "Hepatocyte nuclear factor-4gamma: cDNA sequence, gene organization, and mutation screening in early-onset autosomal-dominant type 2 diabetes". Diabetes. 48 (10): 2099–102. doi:10.2337/diabetes.48.10.2099. PMID 10512380.
  • Ozeki T, Takahashi Y, Nakayama K, Funayama M, Nagashima K, Kodama T, Kamataki T (January 2003). "Hepatocyte nuclear factor-4 alpha/gamma and hepatocyte nuclear factor-1 alpha as causal factors of interindividual difference in the expression of human dihydrodiol dehydrogenase 4 mRNA in human livers". Pharmacogenetics. 13 (1): 49–53. doi:10.1097/00008571-200301000-00007. PMID 12544512.

External links

  • v
  • t
  • e
  • 1lv2: Hepatocyte Nuclear Factor 4 is a Transcription Factor that Constitutively Binds Fatty Acids
    1lv2: Hepatocyte Nuclear Factor 4 is a Transcription Factor that Constitutively Binds Fatty Acids
  • v
  • t
  • e
(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
(1.2) Basic helix-loop-helix (bHLH)
Group A
Group B
Group C
bHLH-PAS
Group D
Group E
Group F
bHLH-COE
(1.3) bHLH-ZIP
(1.4) NF-1
(1.5) RF-X
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1
subfamily 2
subfamily 3
subfamily 4
subfamily 5
subfamily 6
subfamily 0
(2.2) Other Cys4
(2.3) Cys2His2
(2.4) Cys6
(2.5) Alternating composition
(2.6) WRKY
(3) Helix-turn-helix domains
(3.1) Homeodomain
Antennapedia
ANTP class
protoHOX
Hox-like
metaHOX
NK-like
other
(3.2) Paired box
(3.3) Fork head / winged helix
(3.4) Heat shock factors
(3.5) Tryptophan clusters
(3.6) TEA domain
  • transcriptional enhancer factor
(4) β-Scaffold factors with minor groove contacts
(4.1) Rel homology region
(4.2) STAT
(4.3) p53-like
(4.4) MADS box
(4.6) TATA-binding proteins
(4.7) High-mobility group
(4.9) Grainyhead
(4.10) Cold-shock domain
(4.11) Runt
(0) Other transcription factors
(0.2) HMGI(Y)
(0.3) Pocket domain
(0.5) AP-2/EREBP-related factors
(0.6) Miscellaneous
see also transcription factor/coregulator deficiencies
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