COUP-TFI

Protein found in humans
NR2F1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2EBL

Identifiers
AliasesNR2F1, BBOAS, BBSOAS, COUP-TFI, EAR-3, EAR3, ERBAL3, NR2F2, SVP44, TCFCOUP1, TFCOUP1, nuclear receptor subfamily 2 group F member 1, COUPTF1
External IDsOMIM: 132890 MGI: 1352451 HomoloGene: 21158 GeneCards: NR2F1
Gene location (Human)
Chromosome 5 (human)
Chr.Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for NR2F1
Genomic location for NR2F1
Band5q15Start93,583,222 bp[1]
End93,594,611 bp[1]
Gene location (Mouse)
Chromosome 13 (mouse)
Chr.Chromosome 13 (mouse)[2]
Chromosome 13 (mouse)
Genomic location for NR2F1
Genomic location for NR2F1
Band13 C1|13 41.38 cMStart78,337,092 bp[2]
End78,347,876 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • optic nerve

  • seminal vesicula

  • trigeminal ganglion

  • left uterine tube

  • germinal epithelium

  • ganglionic eminence

  • parietal pleura

  • lower lobe of lung

  • spinal ganglia

  • visceral pleura
Top expressed in
  • lateral geniculate nucleus

  • barrel cortex

  • medial dorsal nucleus

  • vas deferens

  • saccule

  • ciliary body

  • subiculum

  • medial geniculate nucleus

  • ganglionic eminence

  • atrium
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • DNA-binding transcription factor activity
  • steroid hormone receptor activity
  • sequence-specific DNA binding
  • transcription coactivator activity
  • DNA binding
  • nuclear receptor activity
  • zinc ion binding
  • protein binding
  • metal ion binding
  • RNA polymerase II cis-regulatory region sequence-specific DNA binding
  • DNA-binding transcription repressor activity, RNA polymerase II-specific
  • DNA-binding transcription factor activity, RNA polymerase II-specific
  • retinoic acid-responsive element binding
Cellular component
  • nucleus
  • nucleoplasm
  • cytosol
Biological process
  • transcription initiation from RNA polymerase II promoter
  • regulation of transcription, DNA-templated
  • negative regulation of transcription by RNA polymerase II
  • transcription, DNA-templated
  • signal transduction
  • steroid hormone mediated signaling pathway
  • intracellular receptor signaling pathway
  • positive regulation of nucleic acid-templated transcription
  • nervous system development
  • negative regulation of neuron projection development
  • positive regulation of transcription by RNA polymerase II
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

7025

13865

Ensembl

ENSG00000175745

ENSMUSG00000069171

UniProt

P10589

Q60632

RefSeq (mRNA)

NM_005654

NM_010151
NM_001347538
NM_001347539

RefSeq (protein)

NP_005645

NP_001334467
NP_001334468
NP_034281
NP_001390702
NP_001390704

NP_001390706

Location (UCSC)Chr 5: 93.58 – 93.59 MbChr 13: 78.34 – 78.35 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

COUP-TF1 (COUP Transcription Factor 1) also known as NR2F1 (Nuclear Receptor subfamily 2, group F, member 1) is a protein that in humans is encoded by the NR2F1 gene.[5][6] This protein is a member of nuclear hormone receptor family of steroid hormone receptors.

Function

Coup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in conjunction with another protein (S300-II) stimulates initiation of transcription.[7][8] COUP-TF1 binds to both direct repeats and palindromes of the 5'-AGGTCA-3' motif.[9]

Interactions

COUP-TFI has been shown to interact with:

Clinical

Mutations in this gene have been associated with Bosch-Boonstra-Schaaf optic atrophy syndrome.[13]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000175745 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000069171 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: NR2F1 nuclear receptor subfamily 2, group F, member 1".
  6. ^ Qiu Y, Krishnan V, Zeng Z, Gilbert DJ, Copeland NG, Gibson L, Yang-Feng T, Jenkins NA, Tsai MJ, Tsai SY (Sep 1995). "Isolation, characterization, and chromosomal localization of mouse and human COUP-TF I and II genes". Genomics. 29 (1): 240–6. doi:10.1006/geno.1995.1237. PMID 8530078.
  7. ^ Sagami I, Tsai SY, Wang H, Tsai MJ, O'Malley BW (Dec 1986). "Identification of two factors required for transcription of the ovalbumin gene". Molecular and Cellular Biology. 6 (12): 4259–67. doi:10.1128/MCB.6.12.4259. PMC 367207. PMID 3796602.
  8. ^ Tsai SY, Sagami I, Wang H, Tsai MJ, O'Malley BW (Aug 1987). "Interactions between a DNA-binding transcription factor (COUP) and a non-DNA binding factor (S300-II)". Cell. 50 (5): 701–9. doi:10.1016/0092-8674(87)90328-X. PMID 3040258. S2CID 25136877.
  9. ^ Tsai SY, Tsai MJ (Apr 1997). "Chick ovalbumin upstream promoter-transcription factors (COUP-TFs): coming of age". Endocrine Reviews. 18 (2): 229–40. doi:10.1210/edrv.18.2.0294. PMID 9101138.
  10. ^ a b Avram D, Fields A, Pretty On Top K, Nevrivy DJ, Ishmael JE, Leid M (Apr 2000). "Isolation of a novel family of C(2)H(2) zinc finger proteins implicated in transcriptional repression mediated by chicken ovalbumin upstream promoter transcription factor (COUP-TF) orphan nuclear receptors". The Journal of Biological Chemistry. 275 (14): 10315–22. doi:10.1074/jbc.275.14.10315. PMC 2819356. PMID 10744719.
  11. ^ Dressel U, Thormeyer D, Altincicek B, Paululat A, Eggert M, Schneider S, Tenbaum SP, Renkawitz R, Baniahmad A (May 1999). "Alien, a highly conserved protein with characteristics of a corepressor for members of the nuclear hormone receptor superfamily". Molecular and Cellular Biology. 19 (5): 3383–94. doi:10.1128/mcb.19.5.3383. PMC 84131. PMID 10207062.
  12. ^ Métivier R, Gay FA, Hübner MR, Flouriot G, Salbert G, Gannon F, Kah O, Pakdel F (Jul 2002). "Formation of an hER alpha-COUP-TFI complex enhances hER alpha AF-1 through Ser118 phosphorylation by MAPK". The EMBO Journal. 21 (13): 3443–53. doi:10.1093/emboj/cdf344. PMC 126093. PMID 12093745.
  13. ^ Hobbs MM, Wolters WC, Rayapati AO (2020) Bosch-Boonstra-Schaaf optic atrophy syndrome presenting as new-onset psychosis in a 32-year-old man: A case report and literature review. J Psychiatr Pract 26(1):58-62

External links

Further reading

  • Kliewer SA, Umesono K, Heyman RA, Mangelsdorf DJ, Dyck JA, Evans RM (Feb 1992). "Retinoid X receptor-COUP-TF interactions modulate retinoic acid signaling". Proceedings of the National Academy of Sciences of the United States of America. 89 (4): 1448–52. Bibcode:1992PNAS...89.1448K. doi:10.1073/pnas.89.4.1448. PMC 48468. PMID 1311101.
  • Berrodin TJ, Marks MS, Ozato K, Linney E, Lazar MA (Sep 1992). "Heterodimerization among thyroid hormone receptor, retinoic acid receptor, retinoid X receptor, chicken ovalbumin upstream promoter transcription factor, and an endogenous liver protein". Molecular Endocrinology. 6 (9): 1468–78. doi:10.1210/mend.6.9.1331778. PMID 1331778. S2CID 24291055.
  • Ing NH, Beekman JM, Tsai SY, Tsai MJ, O'Malley BW (Sep 1992). "Members of the steroid hormone receptor superfamily interact with TFIIB (S300-II)". The Journal of Biological Chemistry. 267 (25): 17617–23. doi:10.1016/S0021-9258(19)37087-5. PMID 1517211.
  • Wang LH, Tsai SY, Cook RG, Beattie WG, Tsai MJ, O'Malley BW (Jul 1989). "COUP transcription factor is a member of the steroid receptor superfamily". Nature. 340 (6229): 163–6. Bibcode:1989Natur.340..163W. doi:10.1038/340163a0. PMID 2739739. S2CID 4364164.
  • Miyajima N, Kadowaki Y, Fukushige S, Shimizu S, Semba K, Yamanashi Y, Matsubara K, Toyoshima K, Yamamoto T (Dec 1988). "Identification of two novel members of erbA superfamily by molecular cloning: the gene products of the two are highly related to each other". Nucleic Acids Research. 16 (23): 11057–74. doi:10.1093/nar/16.23.11057. PMC 338996. PMID 2905047.
  • Sawaya BE, Rohr O, Aunis D, Schaeffer E (Sep 1996). "Chicken ovalbumin upstream promoter transcription factor, a transcriptional activator of HIV-1 gene expression in human brain cells". The Journal of Biological Chemistry. 271 (38): 23572–6. doi:10.1074/jbc.271.38.23572. PMID 8798567.
  • Rohr O, Aunis D, Schaeffer E (Dec 1997). "COUP-TF and Sp1 interact and cooperate in the transcriptional activation of the human immunodeficiency virus type 1 long terminal repeat in human microglial cells". The Journal of Biological Chemistry. 272 (49): 31149–55. doi:10.1074/jbc.272.49.31149. PMID 9388268.
  • Dressel U, Thormeyer D, Altincicek B, Paululat A, Eggert M, Schneider S, Tenbaum SP, Renkawitz R, Baniahmad A (May 1999). "Alien, a highly conserved protein with characteristics of a corepressor for members of the nuclear hormone receptor superfamily". Molecular and Cellular Biology. 19 (5): 3383–94. doi:10.1128/mcb.19.5.3383. PMC 84131. PMID 10207062.
  • Klinge CM, Kaur K, Swanson HI (Jan 2000). "The aryl hydrocarbon receptor interacts with estrogen receptor alpha and orphan receptors COUP-TFI and ERRalpha1". Archives of Biochemistry and Biophysics. 373 (1): 163–74. doi:10.1006/abbi.1999.1552. PMID 10620335.
  • Rohr O, Schwartz C, Hery C, Aunis D, Tardieu M, Schaeffer E (Jan 2000). "The nuclear receptor chicken ovalbumin upstream promoter transcription factor interacts with HIV-1 Tat and stimulates viral replication in human microglial cells". The Journal of Biological Chemistry. 275 (4): 2654–60. doi:10.1074/jbc.275.4.2654. PMID 10644726.
  • Sugiyama T, Wang JC, Scott DK, Granner DK (Feb 2000). "Transcription activation by the orphan nuclear receptor, chicken ovalbumin upstream promoter-transcription factor I (COUP-TFI). Definition of the domain involved in the glucocorticoid response of the phosphoenolpyruvate carboxykinase gene". The Journal of Biological Chemistry. 275 (5): 3446–54. doi:10.1074/jbc.275.5.3446. PMID 10652338.
  • Vlahou A, Flytzanis CN (Feb 2000). "Subcellular trafficking of the nuclear receptor COUP-TF in the early embryonic cell cycle". Developmental Biology. 218 (2): 284–98. doi:10.1006/dbio.1999.9456. PMID 10656770.
  • Avram D, Fields A, Pretty On Top K, Nevrivy DJ, Ishmael JE, Leid M (Apr 2000). "Isolation of a novel family of C(2)H(2) zinc finger proteins implicated in transcriptional repression mediated by chicken ovalbumin upstream promoter transcription factor (COUP-TF) orphan nuclear receptors". The Journal of Biological Chemistry. 275 (14): 10315–22. doi:10.1074/jbc.275.14.10315. PMC 2819356. PMID 10744719.
  • Gay F, Anglade I, Gong Z, Salbert G (Oct 2000). "The LIM/homeodomain protein islet-1 modulates estrogen receptor functions". Molecular Endocrinology. 14 (10): 1627–48. doi:10.1210/me.14.10.1627. PMID 11043578.
  • You M, Fischer M, Cho WK, Crabb D (Feb 2002). "Transcriptional control of the human aldehyde dehydrogenase 2 promoter by hepatocyte nuclear factor 4: inhibition by cyclic AMP and COUP transcription factors". Archives of Biochemistry and Biophysics. 398 (1): 79–86. doi:10.1006/abbi.2001.2713. PMID 11811951.
  • Lin F, Kolluri SK, Chen GQ, Zhang XK (Jun 2002). "Regulation of retinoic acid-induced inhibition of AP-1 activity by orphan receptor chicken ovalbumin upstream promoter-transcription factor". The Journal of Biological Chemistry. 277 (24): 21414–22. doi:10.1074/jbc.M201885200. PMID 11934895.
  • Métivier R, Gay FA, Hübner MR, Flouriot G, Salbert G, Gannon F, Kah O, Pakdel F (Jul 2002). "Formation of an hER alpha-COUP-TFI complex enhances hER alpha AF-1 through Ser118 phosphorylation by MAPK". The EMBO Journal. 21 (13): 3443–53. doi:10.1093/emboj/cdf344. PMC 126093. PMID 12093745.
  • Yu X, Mertz JE (Feb 2003). "Distinct modes of regulation of transcription of hepatitis B virus by the nuclear receptors HNF4alpha and COUP-TF1". Journal of Virology. 77 (4): 2489–99. doi:10.1128/JVI.77.4.2489-2499.2003. PMC 141100. PMID 12551987.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


  • v
  • t
  • e
(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
(1.2) Basic helix-loop-helix (bHLH)
Group A
Group B
Group C
bHLH-PAS
Group D
Group E
Group F
bHLH-COE
(1.3) bHLH-ZIP
(1.4) NF-1
(1.5) RF-X
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1
subfamily 2
subfamily 3
subfamily 4
subfamily 5
subfamily 6
subfamily 0
(2.2) Other Cys4
(2.3) Cys2His2
(2.4) Cys6
(2.5) Alternating composition
(2.6) WRKY
(3) Helix-turn-helix domains
(3.1) Homeodomain
Antennapedia
ANTP class
protoHOX
Hox-like
metaHOX
NK-like
other
(3.2) Paired box
(3.3) Fork head / winged helix
(3.4) Heat shock factors
(3.5) Tryptophan clusters
(3.6) TEA domain
  • transcriptional enhancer factor
(4) β-Scaffold factors with minor groove contacts
(4.1) Rel homology region
(4.2) STAT
(4.3) p53-like
(4.4) MADS box
(4.6) TATA-binding proteins
(4.7) High-mobility group
(4.9) Grainyhead
(4.10) Cold-shock domain
(4.11) Runt
(0) Other transcription factors
(0.2) HMGI(Y)
(0.3) Pocket domain
(0.5) AP-2/EREBP-related factors
(0.6) Miscellaneous
see also transcription factor/coregulator deficiencies